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IID00282
 UniprotQ86U70
ProteinLIM domain-binding protein 1
GeneLDB1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
411
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 56-285 Hetero tetramer : P81877,Q9BRQ0
 Evidence X-RAY 8hib V Reference
       Region 8hib V 56-64 disorder
       Region 8hib V 65-280 order
       Region 8hib V 281-285 disorder
Seq 56-285 Hetero trimer : P81877
 Evidence X-RAY 6tyd V Reference
       Region 6tyd V 56-63 disorder
       Region 6tyd V 64-282 order
       Region 6tyd V 283-285 disorder
Seqdisorder 231-294
 Evidence X-RAY 8ssu A Reference
       Region 8ssu A 231-294 disorder
Seq 334-368 Hetero dimer : IID00268Complex
 Evidence X-RAY 2xjy B Reference
       Region 2xjy B 334-368 order
 Evidence X-RAY 2xjz I Reference
       Region 2xjz I 334-335 disorder
       Region 2xjz I 336-364 order
       Region 2xjz I 365-368 disorder
 Evidence X-RAY 2xjz L Reference
       Region 2xjz L 334-335 disorder
       Region 2xjz L 336-364 order
       Region 2xjz L 365-368 disorder
 Evidence X-RAY 2xjz M Reference
       Region 2xjz M 334-335 disorder
       Region 2xjz M 336-361 order
       Region 2xjz M 362-368 disorder
 Evidence X-RAY 2xjz J Reference
       Region 2xjz J 334-363 order
       Region 2xjz J 364-368 disorder
 Evidence X-RAY 2xjz K Reference
       Region 2xjz K 334-335 disorder
       Region 2xjz K 336-356 order
       Region 2xjz K 357-368 disorder
Seq 336-375 Hetero tetramer : IID00268Complex
 Evidence X-RAY 2ypa D Reference
       Region 2ypa D 336-365 order
       Region 2ypa D 366-375 disorder
Seq 401-411 Hetero dimer : IID00301Complex
 Evidence X-RAY 7ob8 B Reference
       Region 7ob8 B 401-408 disorder
       Region 7ob8 B 409-411 order
 Evidence X-RAY 7ob5 P Reference
       Region 7ob5 P 401-402 disorder
       Region 7ob5 P 403-411 order
SeqProS possible 336-368 Same region of mouse homolog (P70662, 99%identity) is disordered in the free state. Hetero tetramer : IID00268Complex
       Region 2ypa D 336-365 order
SeqProS possible 336-368 Same region of mouse homolog (P70662, 99%identity) is disordered in the free state. Hetero dimer : IID00268Complex
       Region 2xjz I 336-364 order
       Region 2xjz J 334-363 order
       Region 2xjz K 336-356 order
       Region 2xjz L 336-364 order
       Region 2xjz M 336-361 order
       Region 2xjy B 334-368 order
SeqProS predicted 403-411 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00301Complex
       Region 7ob8 B 409-411 order
       Region 7ob5 P 403-411 order
Seqphosphorylation
    302-302 Phosphoserine
    265-265 Phosphoserine
    61-61 Phosphothreonine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-62,222-231,268-411
Order 63-214,232-267
ProS 1-8,228-231,268-284
AlphaFold
Disorder 1-64,285-411
Order 65-284
Pfam Hmmer
PF01803 37-411 1e-298
SEG 300-323 ,391-404
Function
Function in SwissProt
Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state.