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IID00285
 UniprotQ9UI95
ProteinMitotic spindle assembly checkpoint protein MAD2B
GeneMAD2L2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
211
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-211 Hetero dimer : Q96JM3
 Evidence X-RAY 5xpt A Reference
       Region 5xpt A 1-5 disorder
       Region 5xpt A 6-155 order
       Region 5xpt A 156-162 disorder
       Region 5xpt A 163-209 order
       Region 5xpt A 210-211 disorder
Seq 1-211 Hetero tetramer : Q96JM3
 Evidence X-RAY 5xpu A Reference
       Region 5xpu A 1-11 disorder
       Region 5xpu A 12-103 order
       Region 5xpu A 104-109 disorder
       Region 5xpu A 110-155 order
       Region 5xpu A 156-164 disorder
       Region 5xpu A 165-205 order
       Region 5xpu A 206-211 disorder
Seq 1-211 Hetero tetramer : IID00259Complex,IID00284Complex
 Evidence X-RAY 4gk5 A Reference
       Region 4gk5 A 1-8 disorder
       Region 4gk5 A 9-106 order
       Region 4gk5 A 107-109 disorder
       Region 4gk5 A 110-209 order
       Region 4gk5 A 210-211 disorder
Seq 1-211 Hetero trimer : IID00259Complex,IID00284Complex
 Evidence X-RAY 3vu7 C Reference
       Region 3vu7 C 1-9 disorder
       Region 3vu7 C 10-106 order
       Region 3vu7 C 107-109 disorder
       Region 3vu7 C 110-208 order
       Region 3vu7 C 209-211 disorder
 Evidence X-RAY 4ext C Reference
       Region 4ext C 7-105 order
       Region 4ext C 106-111 disorder
       Region 4ext C 112-209 order
Seq 1-211 Hetero dimer : IID00259Complex
 Evidence X-RAY 3abd A Reference
       Region 3abd A 1-11 disorder
       Region 3abd A 12-106 order
       Region 3abd A 107-112 disorder
       Region 3abd A 113-153 order
       Region 3abd A 154-167 disorder
       Region 3abd A 168-211 order
 Evidence X-RAY 3abd B Reference
       Region 3abd B 1-9 disorder
       Region 3abd B 10-153 order
       Region 3abd B 154-160 disorder
       Region 3abd B 161-211 order
 Evidence X-RAY 3abe C Reference
       Region 3abe C 1-10 disorder
       Region 3abe C 11-105 order
       Region 3abe C 106-109 disorder
       Region 3abe C 110-210 order
       Region 3abe C 211-211 disorder
Seq 1-211 Hetero trimer : IID00259Complex,IID00284Complex
 Evidence X-RAY 4gk0 A Reference
       Region 4gk0 A 1-8 disorder
       Region 4gk0 A 9-106 order
       Region 4gk0 A 107-109 disorder
       Region 4gk0 A 110-209 order
       Region 4gk0 A 210-211 disorder
 Evidence X-RAY 4gk0 B Reference
       Region 4gk0 B 1-9 disorder
       Region 4gk0 B 10-104 order
       Region 4gk0 B 105-113 disorder
       Region 4gk0 B 114-208 order
       Region 4gk0 B 209-211 disorder
 Evidence X-RAY 4gk5 B Reference
       Region 4gk5 B 1-9 disorder
       Region 4gk5 B 10-104 order
       Region 4gk5 B 105-113 disorder
       Region 4gk5 B 114-208 order
       Region 4gk5 B 209-211 disorder
 
Prediction
NeProc
Disorder 1-7,208-211
Order 8-207
AlphaFold
Disorder 1-9,107-113,210-211
Order 10-106,114-209
Pfam Hmmer
PF02301 11-200 4.1e-68
SEG 107-117
Function
Function in SwissProt
Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.