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IID00292  RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens) P04049
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
648
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 51-131 Hetero dimer : P01112
 Evidence X-RAY 4g0n B Reference
       Region 4g0n B 54-131 order
 Evidence X-RAY 4g3x B Reference
       Region 4g3x B 55-131 order
 Evidence X-RAY 3kud B Reference
       Region 3kud B 51-55 disorder
       Region 3kud B 56-131 order
Seq 51-131 Hetero dimer : P62834
 Evidence X-RAY 1c1y B Reference
       Region 1c1y B 55-131 order
 Evidence X-RAY 1gua B Reference
       Region 1gua B 51-55 disorder
       Region 1gua B 56-131 order
 Evidence X-RAY 3kuc B Reference
       Region 3kuc B 51-55 disorder
       Region 3kuc B 56-131 order
Seq 55-132 Monomer :
 Evidence NMR 1rfa A Reference
       Region 1rfa A 55-132 order
Seq 136-187 Monomer :
 Evidence NMR 1faq A Reference
       Region 1faq A 136-187 order
       Region 1faq A 136-137 high_rmsd
       Region 1faq A 185-187 high_rmsd
 Evidence NMR 1far A Reference
       Region 1far A 136-187 order
Seq 229-264 Hetero trimer : IID00061Complex
 Evidence X-RAY 4fj3 P Reference
       Region 4fj3 P 229-229 disorder
       Region 4fj3 P 230-235 order
       Region 4fj3 P 236-255 disorder
       Region 4fj3 P 256-263 order
       Region 4fj3 P 264-264 disorder
 Evidence X-RAY 4ihl P Reference
       Region 4ihl P 229-229 disorder
       Region 4ihl P 230-237 order
       Region 4ihl P 238-254 disorder
       Region 4ihl P 255-263 order
       Region 4ihl P 264-264 disorder
Seq 255-264 Hetero tetramer : IID00301Complex
 Evidence X-RAY 3iqj P Reference
       Region 3iqj P 255-262 order
       Region 3iqj P 263-264 disorder
 Evidence X-RAY 3iqu P Reference
       Region 3iqu P 255-260 order
 Evidence X-RAY 3iqv P Reference
       Region 3iqv P 255-260 order
 Evidence X-RAY 3o8i B Reference
       Region 3o8i B 255-255 disorder
       Region 3o8i B 256-263 order
       Region 3o8i B 264-264 disorder
Seq 255-264 Hetero tetramer : IID00061Complex
 Evidence X-RAY 3cu8 P Reference
       Region 3cu8 P 256-264 order
 Evidence X-RAY 3cu8 Q Reference
       Region 3cu8 Q 256-263 order
       Region 3cu8 Q 264-264 disorder
 Evidence X-RAY 3nkx P Reference
       Region 3nkx P 255-255 disorder
       Region 3nkx P 256-264 order
 Evidence X-RAY 3nkx Q Reference
       Region 3nkx Q 255-255 disorder
       Region 3nkx Q 256-263 order
       Region 3nkx Q 264-264 disorder
Seq 323-618 Homo dimer :
 Evidence X-RAY 3omv A Reference
       Region 3omv A 323-339 disorder
       Region 3omv A 340-492 order
       Region 3omv A 493-504 disorder
       Region 3omv A 505-615 order
       Region 3omv A 616-618 disorder
 Evidence X-RAY 3omv B Reference
       Region 3omv B 323-339 disorder
       Region 3omv B 340-492 order
       Region 3omv B 493-504 disorder
       Region 3omv B 505-615 order
       Region 3omv B 616-618 disorder
Seq 618-625 Hetero tetramer : IID00301Complex
 Evidence X-RAY 4iea P Reference
       Region 4iea P 618-625 order
Seqphosphorylation
    29-29 Phosphoserine; by MAPK1
    43-43 Phosphoserine; by PKA and MAPK1
    252-252 Phosphoserine
    259-259 Phosphoserine; by PKA
    268-268 Phosphothreonine; by autocatalysis
    269-269 Phosphothreonine; by PKA
    289-289 Phosphoserine; by MAPK1
    296-296 Phosphoserine
    301-301 Phosphoserine; by MAPK1
    338-338 Phosphoserine; by PAK1
    339-339 Phosphoserine; by PAK1
    340-340 Phosphotyrosine; by SRC
    341-341 Phosphotyrosine; by SRC
    471-471 Phosphoserine
    491-491 Phosphothreonine
    494-494 Phosphoserine
    499-499 Phosphoserine; by PKC
    621-621 Phosphoserine
    642-642 Phosphoserine; by MAPK1
 
Prediction
DICHOT
Disorder 1-54,132-135,188-339,616-648
Known Domain 55-131,136-187,340-615
SCOPe RPS-Blast
     1c1yB 55-131 7e-28 d.15.1.5 A-Raf proto-oncogene serine/threonine-pr...
     1faqA 136-187 1e-20 g.49.1.1 Beta-chimaerin, middle domain
     5itaA 342-609 e-129 d.144.1.0 automated matches
SCOP Hmmer
     1c1yB_ 56-131 7.6e-29 d.15.1.5 A-Raf proto-onco...
     1r79A_ 130-184 2.1e-15 Cysteine-rich domain
     1uwhA_ 344-611 1.6e-74 d.144.1.7 3-phosphoinosi...
Pfam RPS-Blast
     PF02196 58-129 1e-21 Raf-like Ras-binding domain
     PF00130 139-184 6e-08 Phorbol esters/diacylglycer...
     PF06293 418-503 4e-05 Lipopolysaccharide kinase (...
Pfam Hmmer
    PF02196 57-129 1.9e-31 Raf-like Ras-binding domain
    PF00130 139-186 1.6e-15 Phorbol esters/diacylglyce...
    PF07714 351-605 1.9e-66 Protein tyrosine kinase