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IID00293
 UniprotP04626
ProteinReceptor tyrosine-protein kinase erbB-2
GeneERBB2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1255
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-652 Hetero trimer : P0DOX5,Q7Z3Y4
 Evidence X-RAY 6bgt C Reference
       Region 6bgt C 1-22 disorder
       Region 6bgt C 23-121 order
       Region 6bgt C 122-132 disorder
       Region 6bgt C 133-602 order
       Region 6bgt C 603-609 disorder
       Region 6bgt C 610-629 order
       Region 6bgt C 630-652 disorder
Seq 22-530 Monomer :
 Evidence X-RAY 2a91 A Reference
       Region 2a91 A 22-123 order
       Region 2a91 A 124-127 disorder
       Region 2a91 A 128-530 order
Seq 22-639 Hetero dimer :
 Evidence X-RAY 6j71 A Reference
       Region 6j71 A 22-639 order
Seq 23-214 Hetero dimer :
 Evidence X-RAY 3h3b B Reference
       Region 3h3b B 23-199 order
       Region 3h3b B 200-202 disorder
       Region 3h3b B 203-213 order
       Region 3h3b B 214-214 disorder
Seq 23-214 Hetero dimer :
 Evidence X-RAY 3h3b A Reference
       Region 3h3b A 23-214 order
Seq 23-586 Hetero hexamer :
 Evidence X-RAY 3wlw B Reference
       Region 3wlw B 23-123 order
       Region 3wlw B 124-132 disorder
       Region 3wlw B 133-586 order
 Evidence X-RAY 3wlw A Reference
       Region 3wlw A 23-123 order
       Region 3wlw A 124-132 disorder
       Region 3wlw A 133-586 order
Seq 23-586 Hetero trimer :
 Evidence X-RAY 3wsq A Reference
       Region 3wsq A 23-123 order
       Region 3wsq A 124-132 disorder
       Region 3wsq A 133-586 order
Seq 23-628 Hetero trimer :
 Evidence X-RAY 5o4g C Reference
       Region 5o4g C 23-121 order
       Region 5o4g C 122-133 disorder
       Region 5o4g C 134-564 order
       Region 5o4g C 565-628 disorder
Seq 23-629 Hetero dimer : P01857
 Evidence X-RAY 5k33 C Reference
       Region 5k33 C 23-124 order
       Region 5k33 C 125-129 disorder
       Region 5k33 C 130-324 order
       Region 5k33 C 325-327 disorder
       Region 5k33 C 328-385 order
       Region 5k33 C 386-388 disorder
       Region 5k33 C 389-589 order
       Region 5k33 C 590-591 disorder
       Region 5k33 C 592-598 order
       Region 5k33 C 599-629 disorder
Seq 23-629 Hetero trimer :
 Evidence X-RAY 1n8z C Reference
       Region 1n8z C 23-123 order
       Region 1n8z C 124-132 disorder
       Region 1n8z C 133-324 order
       Region 1n8z C 325-327 disorder
       Region 1n8z C 328-382 order
       Region 1n8z C 383-386 disorder
       Region 1n8z C 387-602 order
       Region 1n8z C 603-612 disorder
       Region 1n8z C 613-629 order
Seq 23-646 Hetero trimer : P01834,P01857
 Evidence X-RAY 3be1 A Reference
       Region 3be1 A 23-122 order
       Region 3be1 A 123-132 disorder
       Region 3be1 A 133-383 order
       Region 3be1 A 384-387 disorder
       Region 3be1 A 388-602 order
       Region 3be1 A 603-612 disorder
       Region 3be1 A 613-629 order
       Region 3be1 A 630-646 disorder
Seq 23-646 Hetero trimer :
 Evidence X-RAY 3n85 A Reference
       Region 3n85 A 23-122 order
       Region 3n85 A 123-132 disorder
       Region 3n85 A 133-269 order
       Region 3n85 A 270-274 disorder
       Region 3n85 A 275-642 order
       Region 3n85 A 643-646 disorder
Seq 23-646 Hetero dimer : P38507
 Evidence X-RAY 3mzw A Reference
       Region 3mzw A 23-123 order
       Region 3mzw A 124-132 disorder
       Region 3mzw A 133-600 order
       Region 3mzw A 601-646 disorder
Seq 23-646 Hetero hexamer : Q7Z3Y4
 Evidence X-RAY 1s78 B Reference
       Region 1s78 B 23-123 order
       Region 1s78 B 124-132 disorder
       Region 1s78 B 133-599 order
       Region 1s78 B 600-646 disorder
 Evidence X-RAY 1s78 A Reference
       Region 1s78 A 23-123 order
       Region 1s78 A 124-132 disorder
       Region 1s78 A 133-586 order
       Region 1s78 A 587-646 disorder
Seq 23-652 Hetero trimer :
 Evidence X-RAY 6att A Reference
       Region 6att A 23-123 order
       Region 6att A 124-131 disorder
       Region 6att A 132-597 order
       Region 6att A 598-652 disorder
Seq 23-653 Hetero tetramer : P01857
 Evidence X-RAY 5kwg C Reference
       Region 5kwg C 23-124 order
       Region 5kwg C 125-129 disorder
       Region 5kwg C 130-324 order
       Region 5kwg C 325-327 disorder
       Region 5kwg C 328-385 order
       Region 5kwg C 386-388 disorder
       Region 5kwg C 389-588 order
       Region 5kwg C 589-591 disorder
       Region 5kwg C 592-597 order
       Region 5kwg C 598-653 disorder
Seq 24-219 Hetero tetramer :
 Evidence X-RAY 4hrm C Reference
       Region 4hrm C 24-26 order
       Region 4hrm C 27-27 disorder
       Region 4hrm C 28-120 order
       Region 4hrm C 121-134 disorder
       Region 4hrm C 135-184 order
       Region 4hrm C 185-186 disorder
       Region 4hrm C 187-187 order
       Region 4hrm C 188-191 disorder
       Region 4hrm C 192-199 order
       Region 4hrm C 200-201 disorder
       Region 4hrm C 202-209 order
       Region 4hrm C 210-210 disorder
       Region 4hrm C 211-213 order
       Region 4hrm C 214-219 disorder
 Evidence X-RAY 4hrm A Reference
       Region 4hrm A 24-27 disorder
       Region 4hrm A 28-36 order
       Region 4hrm A 37-37 disorder
       Region 4hrm A 38-54 order
       Region 4hrm A 55-55 disorder
       Region 4hrm A 56-56 order
       Region 4hrm A 57-57 disorder
       Region 4hrm A 58-66 order
       Region 4hrm A 67-68 disorder
       Region 4hrm A 69-73 order
       Region 4hrm A 74-74 disorder
       Region 4hrm A 75-111 order
       Region 4hrm A 112-112 disorder
       Region 4hrm A 113-119 order
       Region 4hrm A 120-134 disorder
       Region 4hrm A 135-148 order
       Region 4hrm A 149-149 disorder
       Region 4hrm A 150-173 order
       Region 4hrm A 174-176 disorder
       Region 4hrm A 177-184 order
       Region 4hrm A 185-186 disorder
       Region 4hrm A 187-189 order
       Region 4hrm A 190-191 disorder
       Region 4hrm A 192-194 order
       Region 4hrm A 195-202 disorder
       Region 4hrm A 203-204 order
       Region 4hrm A 205-219 disorder
Seq 24-219 Hetero dimer :
 Evidence X-RAY 4hrl C Reference
       Region 4hrl C 24-36 order
       Region 4hrl C 37-38 disorder
       Region 4hrl C 39-39 order
       Region 4hrl C 40-40 disorder
       Region 4hrl C 41-121 order
       Region 4hrl C 122-132 disorder
       Region 4hrl C 133-186 order
       Region 4hrl C 187-191 disorder
       Region 4hrl C 192-199 order
       Region 4hrl C 200-201 disorder
       Region 4hrl C 202-213 order
       Region 4hrl C 214-219 disorder
Seq 24-645 Hetero dimer :
 Evidence X-RAY 5my6 A Reference
       Region 5my6 A 24-122 order
       Region 5my6 A 123-131 disorder
       Region 5my6 A 132-334 order
       Region 5my6 A 335-336 disorder
       Region 5my6 A 337-587 order
       Region 5my6 A 588-594 disorder
       Region 5my6 A 595-597 order
       Region 5my6 A 598-645 disorder
Seq 529-625 Hetero dimer :
 Evidence X-RAY 4hrn D This region binds to a peptide. Reference
       Region 4hrn D 529-530 disorder
       Region 4hrn D 531-600 order
       Region 4hrn D 601-625 disorder
Seq 529-625 Hetero dimer :
 Evidence X-RAY 4hrn C This region binds to a peptide. Reference
       Region 4hrn C 529-530 disorder
       Region 4hrn C 531-601 order
       Region 4hrn C 602-625 disorder
Seq 531-626 Hetero dimer :
 Evidence X-RAY 6lbx B Reference
       Region 6lbx B 531-601 order
       Region 6lbx B 602-626 disorder
Seq 641-684 Hetero dimer : IID00262Complex
 Evidence NMR 2ks1 A Reference
       Region 2ks1 A 641-684 order
       Region 2ks1 A 641-646 high_rmsd
       Region 2ks1 A 679-684 high_rmsd
Seq 641-684 Homo dimer :
 Evidence NMR 2jwa B Reference
       Region 2jwa B 641-684 order
       Region 2jwa B 641-647 high_rmsd
       Region 2jwa B 680-684 high_rmsd
 Evidence NMR 2jwa A Reference
       Region 2jwa A 641-684 order
       Region 2jwa A 641-647 high_rmsd
       Region 2jwa A 681-684 high_rmsd
 Evidence NMR 5ob4 B Reference
       Region 5ob4 B 641-684 order
       Region 5ob4 B 641-645 high_rmsd
       Region 5ob4 B 680-684 high_rmsd
 Evidence NMR 5ob4 A Reference
       Region 5ob4 A 641-684 order
       Region 5ob4 A 641-646 high_rmsd
       Region 5ob4 A 680-684 high_rmsd
Seq 644-700 Homo dimer :
 Evidence NMR 2n2a B Reference
       Region 2n2a B 644-700 order
       Region 2n2a B 681-700 high_rmsd
 Evidence NMR 2n2a A Reference
       Region 2n2a A 644-700 order
       Region 2n2a A 681-700 high_rmsd
Seq 654-662 Hetero trimer : P04439
 Evidence X-RAY 1qr1 F Reference
       Region 1qr1 F 654-662 order
 Evidence X-RAY 1qr1 C Reference
       Region 1qr1 C 654-662 order
Seq 703-1024 Homo octamer :
 Evidence X-RAY 7jxh H Reference
       Region 7jxh H 703-706 disorder
       Region 7jxh H 707-756 order
       Region 7jxh H 757-760 disorder
       Region 7jxh H 761-992 order
       Region 7jxh H 993-1024 disorder
 Evidence X-RAY 7jxh G Reference
       Region 7jxh G 703-705 disorder
       Region 7jxh G 706-869 order
       Region 7jxh G 870-883 disorder
       Region 7jxh G 884-992 order
       Region 7jxh G 993-1024 disorder
 Evidence X-RAY 7jxh F Reference
       Region 7jxh F 703-712 disorder
       Region 7jxh F 713-740 order
       Region 7jxh F 741-745 disorder
       Region 7jxh F 746-871 order
       Region 7jxh F 872-883 disorder
       Region 7jxh F 884-991 order
       Region 7jxh F 992-1024 disorder
 Evidence X-RAY 7jxh E Reference
       Region 7jxh E 703-708 disorder
       Region 7jxh E 709-868 order
       Region 7jxh E 869-884 disorder
       Region 7jxh E 885-992 order
       Region 7jxh E 993-1024 disorder
 Evidence X-RAY 7jxh D Reference
       Region 7jxh D 703-706 disorder
       Region 7jxh D 707-879 order
       Region 7jxh D 880-882 disorder
       Region 7jxh D 883-992 order
       Region 7jxh D 993-1024 disorder
 Evidence X-RAY 7jxh C Reference
       Region 7jxh C 703-706 disorder
       Region 7jxh C 707-869 order
       Region 7jxh C 870-881 disorder
       Region 7jxh C 882-992 order
       Region 7jxh C 993-1024 disorder
 Evidence X-RAY 7jxh B Reference
       Region 7jxh B 703-706 disorder
       Region 7jxh B 707-867 order
       Region 7jxh B 868-881 disorder
       Region 7jxh B 882-996 order
       Region 7jxh B 997-1024 disorder
 Evidence X-RAY 7jxh A Reference
       Region 7jxh A 703-705 disorder
       Region 7jxh A 706-868 order
       Region 7jxh A 869-883 disorder
       Region 7jxh A 884-992 order
       Region 7jxh A 993-1024 disorder
Seq 703-1029 Monomer :
 Evidence X-RAY 3pp0 A Reference
       Region 3pp0 A 703-705 disorder
       Region 3pp0 A 706-879 order
       Region 3pp0 A 880-881 disorder
       Region 3pp0 A 882-993 order
       Region 3pp0 A 994-1029 disorder
 Evidence X-RAY 3pp0 B Reference
       Region 3pp0 B 703-705 disorder
       Region 3pp0 B 706-879 order
       Region 3pp0 B 880-881 disorder
       Region 3pp0 B 882-992 order
       Region 3pp0 B 993-998 disorder
       Region 3pp0 B 999-1009 order
       Region 3pp0 B 1010-1029 disorder
 Evidence X-RAY 3rcd A Reference
       Region 3rcd A 713-756 order
       Region 3rcd A 757-760 disorder
       Region 3rcd A 761-866 order
       Region 3rcd A 867-883 disorder
       Region 3rcd A 884-991 order
       Region 3rcd A 992-999 disorder
       Region 3rcd A 1000-1012 order
       Region 3rcd A 1013-1015 disorder
       Region 3rcd A 1016-1022 order
       Region 3rcd A 1023-1028 disorder
 Evidence X-RAY 3rcd B Reference
       Region 3rcd B 713-756 order
       Region 3rcd B 757-760 disorder
       Region 3rcd B 761-865 order
       Region 3rcd B 866-883 disorder
       Region 3rcd B 884-991 order
       Region 3rcd B 992-999 disorder
       Region 3rcd B 1000-1010 order
       Region 3rcd B 1011-1028 disorder
 Evidence X-RAY 3rcd C Reference
       Region 3rcd C 713-756 order
       Region 3rcd C 757-760 disorder
       Region 3rcd C 761-866 order
       Region 3rcd C 867-883 disorder
       Region 3rcd C 884-991 order
       Region 3rcd C 992-999 disorder
       Region 3rcd C 1000-1012 order
       Region 3rcd C 1013-1015 disorder
       Region 3rcd C 1016-1022 order
       Region 3rcd C 1023-1028 disorder
 Evidence X-RAY 3rcd D Reference
       Region 3rcd D 713-756 order
       Region 3rcd D 757-760 disorder
       Region 3rcd D 761-865 order
       Region 3rcd D 866-883 disorder
       Region 3rcd D 884-991 order
       Region 3rcd D 992-999 disorder
       Region 3rcd D 1000-1010 order
       Region 3rcd D 1011-1028 disorder
 Evidence X-RAY 7pcd A Reference
       Region 7pcd A 703-709 disorder
       Region 7pcd A 710-873 order
       Region 7pcd A 874-883 disorder
       Region 7pcd A 884-991 order
       Region 7pcd A 992-1029 disorder
Seqdisorder 988-1255
 Evidence NMR¸ SAXS We show that although this region is highly disordered, it exhibits partially formed alpha-helices and transient long-range contacts. (PMID: 33741354) Reference
       Region 988-1255 disorder
Seq 1109-1114 Hetero octamer : IID00581Complex
 Evidence X-RAY 4nnd H Reference
       Region 4nnd H 1109-1113 order
       Region 4nnd H 1114-1114 disorder
 Evidence X-RAY 4nnd F Reference
       Region 4nnd F 1109-1114 order
 Evidence X-RAY 4nnd E Reference
       Region 4nnd E 1109-1113 order
       Region 4nnd E 1114-1114 disorder
 Evidence X-RAY 4nnd C Reference
       Region 4nnd C 1109-1114 order
Seq 1135-1144 Hetero dimer : IID00566Complex
 Evidence NMR 2l4k B Reference
       Region 2l4k B 1135-1144 order
 Evidence NMR 1mw4 B Reference
       Region 1mw4 B 1135-1144 order
Seq 1218-1228 Hetero dimer : P08487
 Evidence X-RAY 5tqs E Reference
       Region 5tqs E 1218-1219 disorder
       Region 5tqs E 1220-1225 order
       Region 5tqs E 1226-1228 disorder
 Evidence X-RAY 5tqs F Reference
       Region 5tqs F 1218-1218 disorder
       Region 5tqs F 1219-1225 order
       Region 5tqs F 1226-1228 disorder
 Evidence X-RAY 5tqs G Reference
       Region 5tqs G 1218-1225 order
       Region 5tqs G 1226-1228 disorder
 Evidence X-RAY 5tqs H Reference
       Region 5tqs H 1218-1224 order
       Region 5tqs H 1225-1228 disorder
Seq 1246-1252 Hetero dimer : IID00581Complex
 Evidence X-RAY 4gfu F Reference
       Region 4gfu F 1246-1252 order
Seq 1247-1255 Hetero dimer : IID00494Complex
 Evidence X-RAY 1mfg B Reference
       Region 1mfg B 1247-1255 order
 Evidence X-RAY 1mfl B Reference
       Region 1mfl B 1247-1250 disorder
       Region 1mfl B 1251-1255 order
SeqProS verified 1109-1252 Hetero dimer : IID00581Complex
       Region 4gfu F 1246-1252 order
       Region 988-1255 disorder
SeqProS verified 1109-1252 Hetero octamer : IID00581Complex
       Region 4nnd C 1109-1114 order
       Region 4nnd E 1109-1113 order
       Region 4nnd F 1109-1114 order
       Region 4nnd H 1109-1113 order
       Region 988-1255 disorder
SeqProS verified 1135-1144 Hetero dimer : IID00566Complex
       Region 2l4k B 1135-1144 order
       Region 1mw4 B 1135-1144 order
       Region 988-1255 disorder
SeqProS verified 1218-1225 Hetero dimer : P08487
       Region 5tqs E 1220-1225 order
       Region 5tqs F 1219-1225 order
       Region 5tqs G 1218-1225 order
       Region 5tqs H 1218-1224 order
       Region 988-1255 disorder
SeqProS verified 1247-1255 Hetero dimer : IID00494Complex
       Region 1mfl B 1251-1255 order
       Region 1mfg B 1247-1255 order
       Region 988-1255 disorder
Seqphosphorylation
    1248-1248 Phosphotyrosine; by autocatalysis
    1196-1196 Phosphotyrosine
    1166-1166 Phosphothreonine
    1151-1151 Phosphoserine
    1139-1139 Phosphotyrosine
    1112-1112 Phosphotyrosine
    1107-1107 Phosphoserine
    1083-1083 Phosphoserine
    1078-1078 Phosphoserine
    1054-1054 Phosphoserine
    877-877 Phosphotyrosine
    182-182 Phosphothreonine
 
Prediction
NeProc
Disorder 1-17,640-652,676-690,997-1212
Order 18-639,653-675,691-992,1213-1227,1233-1255
ProS 4-17,640-652,676-690,1001-1010,1016-1033,1040-1063,1085-1144,1151-1199
AlphaFold
Disorder 1-23,122-133,605-611,628-658,680-712,729-731,756-770,864-883,990-1018,1021-1255
Order 24-121,134-604,612-627,659-679,713-728,732-755,771-863,884-989,1019-1020
Pfam Hmmer
PF01030 52-173 2e-43
PF00757 189-343 3.6e-94
PF01030 366-486 6.4e-31
PF07714 720-976 2.3e-133
SEG 3-21 ,453-467 ,658-675 ,1044-1063 ,1199-1217
Function
Function in SwissProt
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Biological Process
Diagram with PDB data
ERBB2/PTPN18PTPN18 in complex with HER2-pY1248 phosphor-peptides
ERBB2/ERBINThe Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor
ERBB2/PLCG1Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the receptor tyrosine kinase ErbB2
ERBB2/GRB7Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139
ERBB2/PTPN18Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites