Search Keyword:


Search option:


IID00296
 UniprotP08253
Protein72 kDa type IV collagenase
GeneMMP2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
660
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 30-660 Hetero dimer : P16035
 Evidence X-RAY 1gxd A Reference
       Region 1gxd A 30-450 order
       Region 1gxd A 451-457 disorder
       Region 1gxd A 458-660 order
 Evidence X-RAY 1gxd B Reference
       Region 1gxd B 30-30 disorder
       Region 1gxd B 31-450 order
       Region 1gxd B 451-457 disorder
       Region 1gxd B 458-660 order
Seq 30-660 Monomer :
 Evidence X-RAY 1ck7 A Reference
       Region 1ck7 A 30-30 disorder
       Region 1ck7 A 31-449 order
       Region 1ck7 A 450-460 disorder
       Region 1ck7 A 461-660 order
Seq 32-452 Hetero trimer :
 Evidence X-RAY 1eak D Reference
       Region 1eak D 32-450 order
       Region 1eak D 451-452 disorder
 Evidence X-RAY 1eak B Reference
       Region 1eak B 32-450 order
       Region 1eak B 451-452 disorder
Seq 32-452 Hetero trimer :
 Evidence X-RAY 1eak C Reference
       Region 1eak C 32-449 order
       Region 1eak C 450-452 disorder
 Evidence X-RAY 1eak A Reference
       Region 1eak A 32-452 order
Seq 110-214,395-446 Hetero dimer :
 Evidence NMR 1hov A Reference
       Region 1hov A 110-214 order
       Region 1hov A 395-446 order
Seq 110-218,393-450 Homo trimer :
 Evidence X-RAY 7xgj C Reference
       Region 7xgj C 110-218 order
       Region 7xgj C 393-449 order
       Region 7xgj C 450-450 disorder
 Evidence X-RAY 7xgj B Reference
       Region 7xgj B 110-110 disorder
       Region 7xgj B 111-218 order
       Region 7xgj B 393-449 order
       Region 7xgj B 450-450 disorder
 Evidence X-RAY 7xgj A Reference
       Region 7xgj A 110-218 order
       Region 7xgj A 393-450 order
Seq 110-218,393-450 Hetero dimer : IID00294Complex
 Evidence X-RAY 3ayu A Reference
       Region 3ayu A 110-218 order
       Region 3ayu A 393-449 order
       Region 3ayu A 450-450 disorder
Seq 110-218,393-450 Homo dimer :
 Evidence X-RAY 7xjo B Reference
       Region 7xjo B 110-110 disorder
       Region 7xjo B 111-218 order
       Region 7xjo B 393-449 order
       Region 7xjo B 450-450 disorder
 Evidence X-RAY 7xjo A Reference
       Region 7xjo A 110-110 disorder
       Region 7xjo A 111-218 order
       Region 7xjo A 393-450 order
 Evidence X-RAY 8h78 B Reference
       Region 8h78 B 110-218 order
       Region 8h78 B 393-450 order
 Evidence X-RAY 8h78 A Reference
       Region 8h78 A 110-218 order
       Region 8h78 A 393-450 order
Seq 115-213,394-449 Hetero dimer :
 Evidence X-RAY 1qib A Reference
       Region 1qib A 115-213 order
       Region 1qib A 394-449 order
Seq 223-282 Monomer :
 Evidence NMR 1ks0 A Reference
       Region 1ks0 A 223-278 order
       Region 1ks0 A 276-278 high_rmsd
       Region 1ks0 A 279-282 disorder
Seq 278-336 Monomer :
 Evidence NMR 1cxw A Reference
       Region 1cxw A 278-336 order
       Region 1cxw A 334-336 high_rmsd
Seq 337-394 Monomer :
 Evidence NMR 1j7m A Reference
       Region 1j7m A 337-394 order
       Region 1j7m A 394-394 high_rmsd
Seq 443-660 Monomer :
 Evidence X-RAY 1gen A Reference
       Region 1gen A 443-460 disorder
       Region 1gen A 461-660 order
 Evidence X-RAY 1rtg A Reference
       Region 1rtg A 451-457 disorder
       Region 1rtg A 458-660 order
 
Prediction
NeProc
Disorder 1-48,449-464
Order 49-62,70-448,465-660
ProS 1-39,45-48,449-453
AlphaFold
Disorder 1-32,108-115,450-460
Order 33-107,116-449,461-660
Pfam Hmmer
PF01471 43-101 1.6e-05
PF00413 118-446 6.9e-97
PF00045 475-518 3.7e-10
PF00045 520-563 1.1e-13
PF00045 568-615 2.2e-19
PF00045 617-660 5.8e-07
SEG 14-30 ,453-466
Function
Function in SwissProt
Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.