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IID00300  E3 ubiquitin-protein ligase CBL (Homo sapiens) P22681
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
906
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 25-351 Hetero dimer :
 Evidence X-RAY 3plf B Reference
       Region 3plf B 25-48 disorder
       Region 3plf B 49-349 order
       Region 3plf B 350-351 disorder
Seq 25-351 Hetero tetramer : P08581
 Evidence X-RAY 3bux B Reference
       Region 3bux B 25-46 disorder
       Region 3bux B 47-351 order
 Evidence X-RAY 3bux D Reference
       Region 3bux D 25-46 disorder
       Region 3bux D 47-351 order
Seq 25-351 Hetero dimer : IID00262Complex
 Evidence X-RAY 3buo B Reference
       Region 3buo B 25-47 disorder
       Region 3buo B 48-351 order
 Evidence X-RAY 3buo D Reference
       Region 3buo D 25-47 disorder
       Region 3buo D 48-351 order
 Evidence X-RAY 3ob2 B Reference
       Region 3ob2 B 25-54 disorder
       Region 3ob2 B 55-350 order
       Region 3ob2 B 351-351 disorder
Seq 25-351 Hetero dimer : IID50237Complex
 Evidence X-RAY 1yvh A Reference
       Region 1yvh A 25-47 disorder
       Region 1yvh A 48-351 order
Seq 25-351 Hetero dimer : IID00585Complex
 Evidence X-RAY 3bun B Reference
       Region 3bun B 25-47 disorder
       Region 3bun B 48-351 order
Seq 25-351 Hetero dimer : IID00528Complex
 Evidence X-RAY 5hl0 A Reference
       Region 5hl0 A 47-47 disorder
       Region 5hl0 A 48-350 order
       Region 5hl0 A 351-351 disorder
 Evidence X-RAY 3ob1 B Reference
       Region 3ob1 B 25-54 disorder
       Region 3ob1 B 55-350 order
       Region 3ob1 B 351-351 disorder
 Evidence X-RAY 3bum B Reference
       Region 3bum B 25-47 disorder
       Region 3bum B 48-351 order
Seq 25-351 Hetero dimer :
 Evidence X-RAY 3plf D Reference
       Region 3plf D 25-48 disorder
       Region 3plf D 49-349 order
       Region 3plf D 350-351 disorder
Seq 25-351 Hetero tetramer : P43405
 Evidence X-RAY 3buw B Reference
       Region 3buw B 25-46 disorder
       Region 3buw B 47-351 order
 Evidence X-RAY 3buw D Reference
       Region 3buw D 25-46 disorder
       Region 3buw D 47-351 order
Seq 47-350 Homo trimer :
 Evidence X-RAY 1b47 A Reference
       Region 1b47 A 47-350 order
 Evidence X-RAY 1b47 B Reference
       Region 1b47 B 47-350 order
 Evidence X-RAY 1b47 C Reference
       Region 1b47 C 47-350 order
Seq 47-351 Hetero hexamer : IID00553Complex
 Evidence X-RAY 2cbl A Reference
       Region 2cbl A 47-351 order
Seq 47-351 Hetero dimer : IID00528Complex
 Evidence X-RAY 5hky A Reference
       Region 5hky A 47-47 disorder
       Region 5hky A 48-350 order
       Region 5hky A 351-351 disorder
 Evidence X-RAY 5hkz A Reference
       Region 5hkz A 47-47 disorder
       Region 5hkz A 48-350 order
       Region 5hkz A 351-351 disorder
Seq 47-434 Hetero trimer : IID00553Complex,IID00592Complex
 Evidence X-RAY 1fbv A Reference
       Region 1fbv A 47-434 order
Seq 47-435 Hetero trimer : IID00553Complex
 Evidence X-RAY 5o76 C Reference
       Region 5o76 C 47-47 disorder
       Region 5o76 C 48-434 order
       Region 5o76 C 435-435 disorder
Seq 47-435 Hetero trimer : IID00553Complex
 Evidence X-RAY 5o76 A Reference
       Region 5o76 A 47-49 disorder
       Region 5o76 A 50-434 order
       Region 5o76 A 435-435 disorder
Seq 47-435 Hetero trimer : IID00553Complex,P62837
 Evidence X-RAY 4a4b A Reference
       Region 4a4b A 47-47 disorder
       Region 4a4b A 48-435 order
 Evidence X-RAY 4a4c A Reference
       Region 4a4c A 47-47 disorder
       Region 4a4c A 48-435 order
Seq 47-435 Hetero dimer : IID00553Complex
 Evidence X-RAY 2y1n C Reference
       Region 2y1n C 47-51 disorder
       Region 2y1n C 52-354 order
       Region 2y1n C 355-358 disorder
       Region 2y1n C 359-435 order
 Evidence X-RAY 2y1n A Reference
       Region 2y1n A 47-51 disorder
       Region 2y1n A 52-354 order
       Region 2y1n A 355-361 disorder
       Region 2y1n A 362-435 order
Seq 47-435 Monomer :
 Evidence X-RAY 4gpl B Reference
       Region 4gpl B 47-351 order
 Evidence X-RAY 5hkw A Reference
       Region 5hkw A 47-47 disorder
       Region 5hkw A 48-349 order
       Region 5hkw A 350-351 disorder
 Evidence X-RAY 5hkw B Reference
       Region 5hkw B 47-47 disorder
       Region 5hkw B 48-349 order
       Region 5hkw B 350-351 disorder
 Evidence X-RAY 5hkw C Reference
       Region 5hkw C 47-47 disorder
       Region 5hkw C 48-349 order
       Region 5hkw C 350-351 disorder
 Evidence X-RAY 5hkx A Reference
       Region 5hkx A 47-47 disorder
       Region 5hkx A 48-354 order
       Region 5hkx A 355-362 disorder
       Region 5hkx A 363-429 order
       Region 5hkx A 430-435 disorder
 Evidence X-RAY 5j3x A Reference
       Region 5j3x A 47-356 order
       Region 5j3x A 357-359 disorder
       Region 5j3x A 360-435 order
 Evidence X-RAY 5j3x B Reference
       Region 5j3x B 47-435 order
 Evidence X-RAY 5j3x C Reference
       Region 5j3x C 47-435 order
 Evidence X-RAY 5j3x D Reference
       Region 5j3x D 47-435 order
 Evidence X-RAY 5j3x E Reference
       Region 5j3x E 47-50 disorder
       Region 5j3x E 51-354 order
       Region 5j3x E 355-358 disorder
       Region 5j3x E 359-435 order
 Evidence X-RAY 5j3x F Reference
       Region 5j3x F 47-49 disorder
       Region 5j3x F 50-356 order
       Region 5j3x F 357-358 disorder
       Region 5j3x F 359-435 order
 Evidence X-RAY 2y1m A Reference
       Region 2y1m A 47-353 order
       Region 2y1m A 354-358 disorder
       Region 2y1m A 359-435 order
 Evidence X-RAY 2y1m B Reference
       Region 2y1m B 47-355 order
       Region 2y1m B 356-359 disorder
       Region 2y1m B 360-435 order
 Evidence X-RAY 2y1m C Reference
       Region 2y1m C 47-354 order
       Region 2y1m C 355-358 disorder
       Region 2y1m C 359-435 order
 Evidence X-RAY 2y1m D Reference
       Region 2y1m D 47-354 order
       Region 2y1m D 355-358 disorder
       Region 2y1m D 359-435 order
 Evidence X-RAY 2y1m E Reference
       Region 2y1m E 47-353 order
       Region 2y1m E 354-359 disorder
       Region 2y1m E 360-435 order
 Evidence X-RAY 2y1m F Reference
       Region 2y1m F 47-353 order
       Region 2y1m F 354-358 disorder
       Region 2y1m F 359-435 order
Seq 354-435 Hetero dimer : P62837
 Evidence X-RAY 4a49 A Reference
       Region 4a49 A 354-358 disorder
       Region 4a49 A 359-435 order
Seq 358-437 Monomer :
 Evidence NMR 2k4d A Reference
       Region 2k4d A 358-437 order
       Region 2k4d A 358-376 high_rmsd
       Region 2k4d A 434-437 high_rmsd
Seq 851-906 Monomer :
 Evidence NMR 2juj A Reference
       Region 2juj A 851-906 order
       Region 2juj A 851-853 high_rmsd
       Region 2juj A 901-906 high_rmsd
Seq 856-895 Homo dimer :
 Evidence X-RAY 2oo9 A Reference
       Region 2oo9 A 856-895 order
 Evidence X-RAY 2oo9 B Reference
       Region 2oo9 B 856-895 order
 Evidence X-RAY 2oo9 C Reference
       Region 2oo9 C 856-857 disorder
       Region 2oo9 C 858-895 order
Seqphosphorylation
    371-371 Phosphotyrosine; by INSR
    439-439 Phosphoserine
    452-452 Phosphoserine
    483-483 Phosphoserine
    619-619 Phosphoserine
    642-642 Phosphoserine
    668-668 Phosphoserine
    669-669 Phosphoserine
    674-674 Phosphotyrosine
    700-700 Phosphotyrosine; by ABL1
    731-731 Phosphotyrosine; by SRC
    774-774 Phosphotyrosine
    900-900 Phosphoserine
 
Prediction
DICHOT
Disorder 1-48,435-860,895-906
Known Domain 49-434,861-894
SCOPe RPS-Blast
     3buxB2 48-177 3e-57 a.48.1.1 N-terminal domain of cbl (N-cbl)
     3vrnA2 179-263 5e-37 a.39.1.0 automated matches
     3vrnA3 264-350 3e-40 d.93.1.0 automated matches
     1fbvA4 356-434 7e-32 g.44.1.1 Acute promyelocytic leukaemia proto-on...
SCOP Hmmer
     2cblA2 49-177 2.8e-60 a.48.1.1 N-terminal domai...
     2cblA1 178-263 1.6e-41 a.39.1.7 alpha-Actinin
     2cblA3 264-350 1.9e-50 d.93.1.1 Abl tyrosine ki...
     1fbvA4 356-434 5.3e-45 g.44.1.1 Acute promyeloc...
     1wgnA_ 843-893 3.8e-08 UBA-like
Pfam RPS-Blast
     PF02262 52-175 5e-54 CBL proto-oncogene N-termina...
     PF02761 179-262 1e-33 CBL proto-oncogene N-termin...
     PF02762 264-349 1e-41 CBL proto-oncogene N-termin...
     PF14447 381-429 2e-19 Prokaryotic RING finger fam...
Pfam Hmmer
    PF02262 51-175 1.3e-57 CBL proto-oncogene N-termin...
    PF02761 179-262 2.2e-44 CBL proto-oncogene N-termi...
    PF02762 264-349 7.5e-49 CBL proto-oncogene N-termi...
    PF14447 381-429 4.8e-16 Prokaryotic RING finger fa...
    PF00627 858-892 7.6e-09 UBA/TS-N domain