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IID00305
 UniprotP51449
ProteinNuclear receptor ROR-gamma
GeneRORC
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
518
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 259-518 Hetero dimer :
 Evidence X-RAY 5iz0 A Reference
       Region 5iz0 A 259-264 disorder
       Region 5iz0 A 265-507 order
       Region 5iz0 A 508-518 disorder
Seq 259-518 Hetero dimer :
 Evidence X-RAY 5ejv B Reference
       Region 5ejv B 259-263 disorder
       Region 5ejv B 264-508 order
       Region 5ejv B 509-518 disorder
Seq 259-518 Hetero dimer :
 Evidence X-RAY 5iz0 D Reference
       Region 5iz0 D 259-264 disorder
       Region 5iz0 D 265-507 order
       Region 5iz0 D 508-518 disorder
Seq 259-518 Hetero dimer :
 Evidence X-RAY 5iz0 B Reference
       Region 5iz0 B 259-262 disorder
       Region 5iz0 B 263-507 order
       Region 5iz0 B 508-518 disorder
Seq 259-518 Hetero dimer :
 Evidence X-RAY 5ejv A Reference
       Region 5ejv A 259-262 disorder
       Region 5ejv A 263-507 order
       Region 5ejv A 508-518 disorder
Seq 259-518 Hetero dimer :
 Evidence X-RAY 5iz0 G Reference
       Region 5iz0 G 259-262 disorder
       Region 5iz0 G 263-507 order
       Region 5iz0 G 508-518 disorder
Seq 260-507 Hetero dimer : IID00082Complex
 Evidence X-RAY 5vb6 A Reference
       Region 5vb6 A 260-264 disorder
       Region 5vb6 A 265-507 order
Seq 260-507 Hetero dimer : IID00082Complex
 Evidence X-RAY 5vb5 A Reference
       Region 5vb5 A 260-264 disorder
       Region 5vb5 A 265-507 order
Seq 260-507 Hetero trimer : IID00082Complex
 Evidence X-RAY 3l0l B Reference
       Region 3l0l B 260-507 order
Seq 260-507 Hetero dimer : IID00082Complex
 Evidence X-RAY 5vb7 A Reference
       Region 5vb7 A 260-264 disorder
       Region 5vb7 A 265-507 order
Seq 260-507 Hetero trimer : IID00082Complex
 Evidence X-RAY 3l0l B Reference
       Region 3l0l B 260-507 order
 Evidence X-RAY 3l0l A Reference
       Region 3l0l A 260-260 disorder
       Region 3l0l A 261-507 order
Seq 260-507 Hetero dimer : IID00082Complex
 Evidence X-RAY 5vb3 A Reference
       Region 5vb3 A 260-264 disorder
       Region 5vb3 A 265-507 order
Seq 260-518 Monomer :
 Evidence X-RAY 5ayg A Reference
       Region 5ayg A 261-263 disorder
       Region 5ayg A 264-480 order
       Region 5ayg A 481-518 disorder
 Evidence X-RAY 5ayg B Reference
       Region 5ayg B 261-263 disorder
       Region 5ayg B 264-482 order
       Region 5ayg B 483-518 disorder
 Evidence X-RAY 3b0w A Reference
       Region 3b0w A 265-479 order
       Region 3b0w A 480-507 disorder
 Evidence X-RAY 3b0w B Reference
       Region 3b0w B 265-481 order
       Region 3b0w B 482-507 disorder
 Evidence X-RAY 6b30 A Reference
       Region 6b30 A 265-479 order
 Evidence X-RAY 6b30 B Reference
       Region 6b30 B 265-476 order
       Region 6b30 B 477-479 disorder
 Evidence X-RAY 6bn6 A Reference
       Region 6bn6 A 265-492 order
       Region 6bn6 A 493-508 disorder
 Evidence X-RAY 6bn6 B Reference
       Region 6bn6 B 265-486 order
       Region 6bn6 B 487-508 disorder
 Evidence X-RAY 5c4o A Reference
       Region 5c4o A 267-507 order
 Evidence X-RAY 5c4s A Reference
       Region 5c4s A 267-507 order
 Evidence X-RAY 5c4t A Reference
       Region 5c4t A 267-507 order
 Evidence X-RAY 5c4u A Reference
       Region 5c4u A 267-507 order
 Evidence X-RAY 5eth A Reference
       Region 5eth A 267-268 disorder
       Region 5eth A 269-486 order
       Region 5eth A 487-487 disorder
 Evidence X-RAY 5eth B Reference
       Region 5eth B 267-487 order
 Evidence X-RAY 5ixk A Reference
       Region 5ixk A 268-268 disorder
       Region 5ixk A 269-487 order
 Evidence X-RAY 5ixk B Reference
       Region 5ixk B 268-487 order
 Evidence X-RAY 5k38 A Reference
       Region 5k38 A 265-491 order
       Region 5k38 A 492-507 disorder
 Evidence X-RAY 5k38 B Reference
       Region 5k38 B 265-490 order
       Region 5k38 B 491-507 disorder
 Evidence X-RAY 5k3l A Reference
       Region 5k3l A 265-489 order
       Region 5k3l A 490-507 disorder
 Evidence X-RAY 5k3l B Reference
       Region 5k3l B 265-490 order
       Region 5k3l B 491-507 disorder
 Evidence X-RAY 5k3l C Reference
       Region 5k3l C 265-490 order
       Region 5k3l C 491-507 disorder
 Evidence X-RAY 5k3l D Reference
       Region 5k3l D 265-490 order
       Region 5k3l D 491-507 disorder
 Evidence X-RAY 5k3m A Reference
       Region 5k3m A 265-486 order
       Region 5k3m A 487-507 disorder
 Evidence X-RAY 5k3m B Reference
       Region 5k3m B 265-486 order
       Region 5k3m B 487-507 disorder
 Evidence X-RAY 5k3n A Reference
       Region 5k3n A 265-492 order
       Region 5k3n A 493-507 disorder
 Evidence X-RAY 5k3n B Reference
       Region 5k3n B 265-490 order
       Region 5k3n B 491-507 disorder
 Evidence X-RAY 5k3n C Reference
       Region 5k3n C 265-492 order
       Region 5k3n C 493-507 disorder
 Evidence X-RAY 5k3n D Reference
       Region 5k3n D 265-492 order
       Region 5k3n D 493-507 disorder
 Evidence X-RAY 5k6e A Reference
       Region 5k6e A 265-490 order
       Region 5k6e A 491-507 disorder
 Evidence X-RAY 5k6e B Reference
       Region 5k6e B 265-498 order
       Region 5k6e B 499-507 disorder
 Evidence X-RAY 5k74 A Reference
       Region 5k74 A 265-491 order
       Region 5k74 A 492-507 disorder
 Evidence X-RAY 5k74 B Reference
       Region 5k74 B 265-491 order
       Region 5k74 B 492-507 disorder
 Evidence X-RAY 5m96 A Reference
       Region 5m96 A 263-264 disorder
       Region 5m96 A 265-489 order
       Region 5m96 A 490-491 disorder
 Evidence X-RAY 5m96 B Reference
       Region 5m96 B 263-264 disorder
       Region 5m96 B 265-487 order
       Region 5m96 B 488-491 disorder
 Evidence X-RAY 4nb6 A Reference
       Region 4nb6 A 262-265 disorder
       Region 4nb6 A 266-486 order
       Region 4nb6 A 487-507 disorder
 Evidence X-RAY 4nb6 B Reference
       Region 4nb6 B 262-265 disorder
       Region 4nb6 B 266-487 order
       Region 4nb6 B 488-507 disorder
 Evidence X-RAY 5ntk A Reference
       Region 5ntk A 263-264 disorder
       Region 5ntk A 265-489 order
       Region 5ntk A 490-491 disorder
 Evidence X-RAY 5ntk B Reference
       Region 5ntk B 263-264 disorder
       Region 5ntk B 265-489 order
       Region 5ntk B 490-491 disorder
 Evidence X-RAY 5ntp A Reference
       Region 5ntp A 263-492 order
       Region 5ntp A 493-499 disorder
 Evidence X-RAY 5ntq A Reference
       Region 5ntq A 263-264 disorder
       Region 5ntq A 265-498 order
       Region 5ntq A 499-499 disorder
 Evidence X-RAY 5ntq B Reference
       Region 5ntq B 263-264 disorder
       Region 5ntq B 265-487 order
       Region 5ntq B 488-499 disorder
 Evidence X-RAY 4qm0 A Reference
       Region 4qm0 A 262-264 disorder
       Region 4qm0 A 265-498 order
       Region 4qm0 A 499-507 disorder
 Evidence X-RAY 4qm0 C Reference
       Region 4qm0 C 262-264 disorder
       Region 4qm0 C 265-484 order
       Region 4qm0 C 485-494 disorder
       Region 4qm0 C 495-507 order
 Evidence X-RAY 5ufo A Reference
       Region 5ufo A 265-489 order
       Region 5ufo A 490-507 disorder
 Evidence X-RAY 5ufr A Reference
       Region 5ufr A 265-487 order
       Region 5ufr A 488-507 disorder
 Evidence X-RAY 5ufr B Reference
       Region 5ufr B 265-487 order
       Region 5ufr B 488-507 disorder
 Evidence X-RAY 5uhi A Reference
       Region 5uhi A 265-487 order
       Region 5uhi A 488-507 disorder
 Evidence X-RAY 5uhi B Reference
       Region 5uhi B 265-487 order
       Region 5uhi B 488-507 disorder
 Evidence X-RAY 4ymq A Reference
       Region 4ymq A 260-264 disorder
       Region 4ymq A 265-507 order
 Evidence X-RAY 4ypq A Reference
       Region 4ypq A 265-507 order
 Evidence X-RAY 4zjr A Reference
       Region 4zjr A 265-481 order
       Region 4zjr A 482-487 disorder
 Evidence X-RAY 4zjr B Reference
       Region 4zjr B 265-484 order
       Region 4zjr B 485-487 disorder
 Evidence X-RAY 4zjr C Reference
       Region 4zjr C 265-483 order
       Region 4zjr C 484-487 disorder
 Evidence X-RAY 4zjr D Reference
       Region 4zjr D 265-481 order
       Region 4zjr D 482-487 disorder
 Evidence X-RAY 4zjw A Reference
       Region 4zjw A 265-267 disorder
       Region 4zjw A 268-486 order
       Region 4zjw A 487-487 disorder
 Evidence X-RAY 4zjw B Reference
       Region 4zjw B 265-265 disorder
       Region 4zjw B 266-487 order
 Evidence X-RAY 4zom A Reference
       Region 4zom A 265-487 order
 Evidence X-RAY 4zom B Reference
       Region 4zom B 265-486 order
       Region 4zom B 487-487 disorder
 Evidence X-RAY 4zom C Reference
       Region 4zom C 265-267 disorder
       Region 4zom C 268-486 order
       Region 4zom C 487-487 disorder
 Evidence X-RAY 4zom D Reference
       Region 4zom D 265-265 disorder
       Region 4zom D 266-480 order
       Region 4zom D 481-487 disorder
 Evidence X-RAY 5lwp A Reference
       Region 5lwp A 265-506 order
Seq 261-518 Hetero dimer : IID00109Complex
 Evidence X-RAY 5x8q A Reference
       Region 5x8q A 261-265 disorder
       Region 5x8q A 266-493 order
       Region 5x8q A 494-518 disorder
 Evidence X-RAY 5x8q C Reference
       Region 5x8q C 261-265 disorder
       Region 5x8q C 266-493 order
       Region 5x8q C 494-518 disorder
 Evidence X-RAY 5x8q E Reference
       Region 5x8q E 261-265 disorder
       Region 5x8q E 266-493 order
       Region 5x8q E 494-518 disorder
 Evidence X-RAY 5x8q G Reference
       Region 5x8q G 261-265 disorder
       Region 5x8q G 266-493 order
       Region 5x8q G 494-518 disorder
Seq 262-507 Hetero tetramer :
 Evidence X-RAY 4wlb B Reference
       Region 4wlb B 262-507 order
 Evidence X-RAY 4wlb A Reference
       Region 4wlb A 262-507 order
Seq 262-507 Hetero trimer :
 Evidence X-RAY 5apk A Reference
       Region 5apk A 265-486 order
       Region 5apk A 487-507 disorder
 Evidence X-RAY 5apk B Reference
       Region 5apk B 265-500 order
       Region 5apk B 501-507 disorder
 Evidence X-RAY 4wqp A Reference
       Region 4wqp A 262-264 disorder
       Region 4wqp A 265-498 order
       Region 4wqp A 499-507 disorder
 Evidence X-RAY 4wqp B Reference
       Region 4wqp B 262-265 disorder
       Region 4wqp B 266-486 order
       Region 4wqp B 487-507 disorder
 Evidence X-RAY 5apk D Reference
       Region 5apk D 480-492 order
 Evidence X-RAY 4wqp P Reference
       Region 4wqp P 480-492 order
Seq 262-509 Hetero dimer :
 Evidence X-RAY 4wpf A Reference
       Region 4wpf A 262-263 disorder
       Region 4wpf A 264-509 order
Seq 262-509 Hetero dimer :
 Evidence X-RAY 4wpf D Reference
       Region 4wpf D 262-263 disorder
       Region 4wpf D 264-509 order
Seq 262-518 Hetero dimer : IID00050Complex
 Evidence X-RAY 5nti A Reference
       Region 5nti A 263-263 disorder
       Region 5nti A 264-508 order
       Region 5nti A 509-518 disorder
 Evidence X-RAY 5nti B Reference
       Region 5nti B 263-263 disorder
       Region 5nti B 264-507 order
       Region 5nti B 508-518 disorder
 Evidence X-RAY 5nti C Reference
       Region 5nti C 263-263 disorder
       Region 5nti C 264-508 order
       Region 5nti C 509-518 disorder
 Evidence X-RAY 5nti D Reference
       Region 5nti D 263-263 disorder
       Region 5nti D 264-507 order
       Region 5nti D 508-518 disorder
 Evidence X-RAY 5ntn A Reference
       Region 5ntn A 263-263 disorder
       Region 5ntn A 264-508 order
       Region 5ntn A 509-518 disorder
 Evidence X-RAY 5ntn B Reference
       Region 5ntn B 263-263 disorder
       Region 5ntn B 264-507 order
       Region 5ntn B 508-518 disorder
 Evidence X-RAY 5ntn C Reference
       Region 5ntn C 263-263 disorder
       Region 5ntn C 264-508 order
       Region 5ntn C 509-518 disorder
 Evidence X-RAY 5ntn D Reference
       Region 5ntn D 263-263 disorder
       Region 5ntn D 264-507 order
       Region 5ntn D 508-518 disorder
 Evidence X-RAY 5ntw A Reference
       Region 5ntw A 263-263 disorder
       Region 5ntw A 264-508 order
       Region 5ntw A 509-518 disorder
 Evidence X-RAY 5ntw B Reference
       Region 5ntw B 263-263 disorder
       Region 5ntw B 264-508 order
       Region 5ntw B 509-518 disorder
 Evidence X-RAY 5ntw C Reference
       Region 5ntw C 263-263 disorder
       Region 5ntw C 264-508 order
       Region 5ntw C 509-518 disorder
 Evidence X-RAY 5ntw D Reference
       Region 5ntw D 263-263 disorder
       Region 5ntw D 264-508 order
       Region 5ntw D 509-518 disorder
 Evidence X-RAY 5nu1 A Reference
       Region 5nu1 A 263-263 disorder
       Region 5nu1 A 264-508 order
       Region 5nu1 A 509-518 disorder
 Evidence X-RAY 5nu1 B Reference
       Region 5nu1 B 263-263 disorder
       Region 5nu1 B 264-508 order
       Region 5nu1 B 509-518 disorder
 Evidence X-RAY 4s14 A Reference
       Region 4s14 A 262-262 disorder
       Region 4s14 A 263-507 order
       Region 4s14 A 508-518 disorder
Seq 263-509 Hetero dimer : IID00082Complex
 Evidence X-RAY 5aph A Reference
       Region 5aph A 265-507 order
 Evidence X-RAY 5apj A Reference
       Region 5apj A 265-507 order
 Evidence X-RAY 5g42 A Reference
       Region 5g42 A 265-507 order
 Evidence X-RAY 5g43 A Reference
       Region 5g43 A 265-507 order
 Evidence X-RAY 5g44 A Reference
       Region 5g44 A 265-507 order
 Evidence X-RAY 3kyt A Reference
       Region 3kyt A 265-507 order
 Evidence X-RAY 3l0j A Reference
       Region 3l0j A 265-507 order
 Evidence X-RAY 4nie A Reference
       Region 4nie A 263-263 disorder
       Region 4nie A 264-508 order
       Region 4nie A 509-509 disorder
 Evidence X-RAY 4nie B Reference
       Region 4nie B 263-263 disorder
       Region 4nie B 264-508 order
       Region 4nie B 509-509 disorder
 Evidence X-RAY 5g45 A Reference
       Region 5g45 A 265-507 order
 Evidence X-RAY 5g46 A Reference
       Region 5g46 A 265-507 order
Seq 265-481 Homo dimer :
 Evidence X-RAY 5w4r A Reference
       Region 5w4r A 265-478 order
       Region 5w4r A 479-481 disorder
 Evidence X-RAY 5w4r B Reference
       Region 5w4r B 265-481 order
 Evidence X-RAY 5w4v A Reference
       Region 5w4v A 266-266 disorder
       Region 5w4v A 267-475 order
 Evidence X-RAY 5w4v B Reference
       Region 5w4v B 266-266 disorder
       Region 5w4v B 267-475 order
 Evidence X-RAY 5w4v C Reference
       Region 5w4v C 266-269 disorder
       Region 5w4v C 270-475 order
 Evidence X-RAY 5w4v F Reference
       Region 5w4v F 266-266 disorder
       Region 5w4v F 267-468 order
       Region 5w4v F 469-475 disorder
 Evidence X-RAY 5w4v D Reference
       Region 5w4v D 266-468 order
       Region 5w4v D 469-475 disorder
 Evidence X-RAY 5w4v E Reference
       Region 5w4v E 266-266 disorder
       Region 5w4v E 267-472 order
       Region 5w4v E 473-475 disorder
Seq 265-507 Hetero dimer : IID00083Complex
 Evidence X-RAY 5yp6 A Reference
       Region 5yp6 A 265-507 order
Seq 265-507 Hetero dimer :
 Evidence X-RAY 4xt9 A Reference
       Region 4xt9 A 265-507 order
SeqProS verified 480-493 Hetero dimer : IID00109Complex
       Region 5x8q A 266-493 order
       Region 5x8q C 266-493 order
       Region 5x8q E 266-493 order
       Region 5x8q G 266-493 order
       Region 3b0w A 480-507 disorder
SeqProS verified 480-500 Hetero trimer :
       Region 5apk B 265-500 order
       Region 5apk D 480-492 order
       Region 3b0w A 480-507 disorder
SeqProS verified 480-507 Hetero dimer :
       Region 5iz0 D 265-507 order
       Region 3b0w A 480-507 disorder
SeqProS verified 480-507 Hetero dimer :
       Region 5iz0 G 263-507 order
       Region 3b0w A 480-507 disorder
SeqProS verified 480-507 Hetero trimer : IID00082Complex
       Region 3l0l B 260-507 order
       Region 3b0w A 480-507 disorder
SeqProS verified 480-507 Hetero dimer : IID00082Complex
       Region 3kyt A 265-507 order
       Region 3l0j A 265-507 order
       Region 4nie A 264-508 order
       Region 4nie B 264-508 order
       Region 5g44 A 265-507 order
       Region 5g43 A 265-507 order
       Region 5aph A 265-507 order
       Region 5g42 A 265-507 order
       Region 5g45 A 265-507 order
       Region 5g46 A 265-507 order
       Region 5apj A 265-507 order
       Region 3b0w A 480-507 disorder
SeqProS verified 480-507 Hetero dimer : IID00050Complex
       Region 5nti A 264-508 order
       Region 5nti B 264-507 order
       Region 5nti C 264-508 order
       Region 5nti D 264-507 order
       Region 5nu1 A 264-508 order
       Region 5nu1 B 264-508 order
       Region 5ntn A 264-508 order
       Region 5ntn B 264-507 order
       Region 5ntn C 264-508 order
       Region 5ntn D 264-507 order
       Region 5ntw A 264-508 order
       Region 5ntw B 264-508 order
       Region 5ntw C 264-508 order
       Region 5ntw D 264-508 order
       Region 3b0w A 480-507 disorder
SeqProS verified 480-507 Hetero dimer :
       Region 5iz0 B 263-507 order
       Region 3b0w A 480-507 disorder
SeqProS verified 480-507 Hetero trimer : IID00082Complex
       Region 3l0l A 261-507 order
       Region 3l0l B 260-507 order
       Region 3b0w A 480-507 disorder
SeqProS verified 480-507 Hetero dimer :
       Region 5iz0 A 265-507 order
       Region 3b0w A 480-507 disorder
 
Prediction
NeProc
Disorder 1-28,102-271,514-518
Order 29-101,272-513
ProS 1-4,102-122,204-208,217-236,241-271,514-518
AlphaFold
Disorder 1-24,61-62,102-106,129-264,508-518
Order 25-60,63-101,107-128,265-507
Pfam Hmmer
PF00105 29-104 1.5e-52
PF00104 325-505 1e-42
SEG 119-130
Function
Function in SwissProt
Isoform 2
Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches. Required for the generation of LTi (lymphoid tissue inducer) cells. Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2. Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus.