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IID00312
 UniprotP63000
ProteinRas-related C3 botulinum toxin substrate 1
GeneRAC1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
192
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-177 Hetero dimer : Q92608
 Evidence X-RAY 2yin C Reference
       Region 2yin C 1-177 order
 Evidence X-RAY 2yin D Reference
       Region 2yin D 1-177 order
Seq 1-177 Hetero trimer : P70206
 Evidence X-RAY 3ryt C Reference
       Region 3ryt C 1-1 disorder
       Region 3ryt C 2-60 order
       Region 3ryt C 61-61 disorder
       Region 3ryt C 62-176 order
       Region 3ryt C 177-177 disorder
Seq 1-177 Hetero tetramer : Q92608
 Evidence X-RAY 3b13 B Reference
       Region 3b13 B 1-177 order
 Evidence X-RAY 3b13 D Reference
       Region 3b13 D 1-177 order
Seq 1-177 Hetero dimer : P97924
 Evidence X-RAY 5o33 A Reference
       Region 5o33 A 1-177 order
Seq 1-177 Hetero dimer : O75962
 Evidence X-RAY 2nz8 A Reference
       Region 2nz8 A 1-177 order
Seq 1-177 Hetero dimer : O43157
 Evidence X-RAY 3su8 A Reference
       Region 3su8 A 1-177 order
 Evidence X-RAY 3sua A Reference
       Region 3sua A 1-177 order
 Evidence X-RAY 3sua B Reference
       Region 3sua B 1-177 order
 Evidence X-RAY 3sua C Reference
       Region 3sua C 1-177 order
Seq 1-177 Hetero dimer : Q60610
 Evidence X-RAY 1foe B Reference
       Region 1foe B 1-177 order
 Evidence X-RAY 1foe D Reference
       Region 1foe D 1-177 order
 Evidence X-RAY 1foe F Reference
       Region 1foe F 1-177 order
 Evidence X-RAY 1foe H Reference
       Region 1foe H 1-177 order
Seq 1-177 Hetero dimer : Q00722
 Evidence X-RAY 2fju A Reference
       Region 2fju A 1-177 order
Seq 1-177 Hetero dimer : IID00652Complex
 Evidence X-RAY 3bji C Reference
       Region 3bji C 1-177 order
 Evidence X-RAY 3bji D Reference
       Region 3bji D 1-2 disorder
       Region 3bji D 3-30 order
       Region 3bji D 31-31 disorder
       Region 3bji D 32-45 order
       Region 3bji D 46-48 disorder
       Region 3bji D 49-123 order
       Region 3bji D 124-129 disorder
       Region 3bji D 130-176 order
       Region 3bji D 177-177 disorder
Seq 1-180 Hetero trimer : O49003
 Evidence X-RAY 5hzh A Reference
       Region 5hzh A 1-2 disorder
       Region 5hzh A 3-29 order
       Region 5hzh A 30-31 disorder
       Region 5hzh A 32-178 order
       Region 5hzh A 179-180 disorder
Seq 1-184 Homo trimer :
 Evidence X-RAY 2p2l A Reference
       Region 2p2l A 1-44 order
       Region 2p2l A 45-47 disorder
       Region 2p2l A 48-179 order
       Region 2p2l A 180-184 disorder
 Evidence X-RAY 2p2l B Reference
       Region 2p2l B 1-48 order
       Region 2p2l B 49-49 disorder
       Region 2p2l B 50-179 order
       Region 2p2l B 180-184 disorder
 Evidence X-RAY 2p2l C Reference
       Region 2p2l C 1-179 order
       Region 2p2l C 180-184 disorder
Seq 1-184 Hetero dimer : P74873
 Evidence X-RAY 1g4u R Reference
       Region 1g4u R 1-180 order
       Region 1g4u R 181-184 disorder
Seq 1-184 Hetero dimer : P27870
 Evidence X-RAY 2vrw A Reference
       Region 2vrw A 1-177 order
       Region 2vrw A 178-184 disorder
Seq 1-184 Hetero dimer : Q05608
 Evidence X-RAY 2h7v A Reference
       Region 2h7v A 1-178 order
       Region 2h7v A 179-184 disorder
 Evidence X-RAY 2h7v B Reference
       Region 2h7v B 1-179 order
       Region 2h7v B 180-184 disorder
Seq 1-184 Monomer :
 Evidence X-RAY 1mh1 A Reference
       Region 1mh1 A 2-181 order
       Region 1mh1 A 182-184 disorder
 Evidence X-RAY 1ryf A Reference
       Region 1ryf A 1-59 order
       Region 1ryf A 60-74 disorder
       Region 1ryf A 75-182 order
 Evidence X-RAY 1ryf B Reference
       Region 1ryf B 1-58 order
       Region 1ryf B 59-74 disorder
       Region 1ryf B 75-180 order
       Region 1ryf B 181-182 disorder
 Evidence X-RAY 1ryh A Reference
       Region 1ryh A 1-60 order
       Region 1ryh A 61-74 disorder
       Region 1ryh A 75-182 order
 Evidence X-RAY 1ryh B Reference
       Region 1ryh B 1-58 order
       Region 1ryh B 59-74 disorder
       Region 1ryh B 75-180 order
       Region 1ryh B 181-182 disorder
 Evidence X-RAY 3sbd A Reference
       Region 3sbd A 2-177 order
 Evidence X-RAY 3sbd B Reference
       Region 3sbd B 2-177 order
 Evidence X-RAY 3sbe A Reference
       Region 3sbe A 2-177 order
 Evidence X-RAY 3th5 A Reference
       Region 3th5 A 2-177 order
 Evidence X-RAY 3th5 B Reference
       Region 3th5 B 2-29 order
       Region 3th5 B 30-34 disorder
       Region 3th5 B 35-177 order
 Evidence X-RAY 4gzl A Reference
       Region 4gzl A 2-2 disorder
       Region 4gzl A 3-30 order
       Region 4gzl A 31-31 disorder
       Region 4gzl A 32-47 order
       Region 4gzl A 48-48 disorder
       Region 4gzl A 49-177 order
 Evidence X-RAY 4gzl B Reference
       Region 4gzl B 2-29 order
       Region 4gzl B 30-30 disorder
       Region 4gzl B 31-176 order
       Region 4gzl B 177-177 disorder
 Evidence X-RAY 4gzm A Reference
       Region 4gzm A 2-3 disorder
       Region 4gzm A 4-177 order
 Evidence X-RAY 4gzm B Reference
       Region 4gzm B 2-3 disorder
       Region 4gzm B 4-177 order
 Evidence X-RAY 5n6o A Reference
       Region 5n6o A 2-177 order
 Evidence X-RAY 5n6o B Reference
       Region 5n6o B 2-177 order
Seq 1-192 Hetero dimer : IID00416Complex
 Evidence NMR 2rmk A Reference
       Region 2rmk A 1-192 order
       Region 2rmk A 190-192 high_rmsd
Seq 1-192 Hetero dimer : Q8TCU6
 Evidence X-RAY 4yon B Reference
       Region 4yon B 1-176 order
       Region 4yon B 177-177 disorder
 Evidence X-RAY 5fi0 B Reference
       Region 5fi0 B 1-2 disorder
       Region 5fi0 B 3-178 order
       Region 5fi0 B 179-192 disorder
 Evidence X-RAY 5fi0 D Reference
       Region 5fi0 D 1-1 disorder
       Region 5fi0 D 2-179 order
       Region 5fi0 D 180-192 disorder
 Evidence X-RAY 5fi0 F Reference
       Region 5fi0 F 1-181 order
       Region 5fi0 F 182-192 disorder
 Evidence X-RAY 5fi0 H Reference
       Region 5fi0 H 1-2 disorder
       Region 5fi0 H 3-181 order
       Region 5fi0 H 182-192 disorder
Seq 1-192 Hetero trimer : P53365
 Evidence X-RAY 1i4d D Reference
       Region 1i4d D 1-1 disorder
       Region 1i4d D 2-178 order
       Region 1i4d D 179-192 disorder
 Evidence X-RAY 1i4l D Reference
       Region 1i4l D 1-1 disorder
       Region 1i4l D 2-178 order
       Region 1i4l D 179-192 disorder
 Evidence X-RAY 1i4t D Reference
       Region 1i4t D 1-1 disorder
       Region 1i4t D 2-178 order
       Region 1i4t D 179-192 disorder
Seq 2-176 Hetero tetramer : Q51451
 Evidence X-RAY 1he1 C Reference
       Region 1he1 C 2-176 order
 Evidence X-RAY 1he1 D Reference
       Region 1he1 D 2-176 order
Seq 2-177 Hetero tetramer : Q8N1W1
 Evidence X-RAY 6bc1 A Reference
       Region 6bc1 A 2-177 order
 Evidence X-RAY 6bc1 B Reference
       Region 6bc1 B 2-177 order
Seq 2-192 Hetero dimer : IID00299Complex
 Evidence X-RAY 1e96 A Reference
       Region 1e96 A 2-178 order
       Region 1e96 A 179-192 disorder
Seq 2-192 Hetero dimer : IID00273Complex
 Evidence X-RAY 1hh4 A Reference
       Region 1hh4 A 2-189 order
       Region 1hh4 A 190-192 disorder
 Evidence X-RAY 1hh4 B Reference
       Region 1hh4 B 2-189 order
       Region 1hh4 B 190-192 disorder
Seq 4-180 Hetero dimer : O49003
 Evidence X-RAY 2wkr A Reference
       Region 2wkr A 4-178 order
       Region 2wkr A 179-180 disorder
Seq 4-180 Hetero dimer : O49003
 Evidence X-RAY 2wkq A Reference
       Region 2wkq A 4-178 order
       Region 2wkq A 179-180 disorder
Seq 4-180 Hetero dimer : O49003
 Evidence X-RAY 2wkp A Reference
       Region 2wkp A 4-180 order
SeqProS verified 179-188 Hetero dimer : IID00273Complex
       Region 1hh4 A 2-189 order
       Region 1hh4 B 2-189 order
       Region 1e96 A 179-192 disorder
SeqProS verified 179-192 Hetero dimer : IID00416Complex
       Region 2rmk A 1-192 order
       Region 1e96 A 179-192 disorder
Seqphosphorylation
    71-71 Phosphoserine
    71-71 Phosphoserine
 
Prediction
NeProc
Disorder 182-192
Order 1-181
ProS 187-192
AlphaFold
Disorder 181-192
Order 1-180
Pfam Hmmer
PF00071 5-178 2.9e-92
SEG 176-192
Function
Function in SwissProt
Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.
Biological Process
See also
Diagram with PDB data
PAK1Crystal structure of PAK1 kinase domain with ruthenium complex lambda-FL172