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IID00315
 UniprotQ05066
ProteinSex-determining region Y protein
GeneSRY
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
204
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 56-130 Hetero dimer : P63159
 Evidence NMR 2gzk A Reference
       Region 2gzk A 56-130 order
Seq 56-140 Monomer :
 Evidence NMR 1hry A Reference
       Region 1hry A 56-57 disorder
       Region 1hry A 58-130 order
       Region 1hry A 131-131 disorder
 Evidence NMR 1hrz A Reference
       Region 1hrz A 56-57 disorder
       Region 1hrz A 58-130 order
       Region 1hrz A 131-131 disorder
 Evidence NMR 1j46 A Reference
       Region 1j46 A 57-140 order
 Evidence NMR 1j47 A Reference
       Region 1j47 A 57-140 order
Seqacetylation
    136-136 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-60,133-204
Order 61-132
ProS 5-9,15-18,57-60,158-170,198-204
AlphaFold
Disorder 1-57,140-201,203-204
Order 58-139,202-202
Pfam Hmmer
PF00505 60-128 7.1e-32
Function
Function in SwissProt
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.