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IID00319  E3 ubiquitin-protein ligase CBL-B (Homo sapiens) Q13191
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
982
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 36-427 Hetero tetramer : IID00553Complex,P0CG48,P62837
 Evidence X-RAY 3zni A Reference
       Region 3zni A 36-37 disorder
       Region 3zni A 38-427 order
 Evidence X-RAY 3zni E Reference
       Region 3zni E 36-37 disorder
       Region 3zni E 38-427 order
 Evidence X-RAY 3zni I Reference
       Region 3zni I 36-40 disorder
       Region 3zni I 41-426 order
       Region 3zni I 427-427 disorder
 Evidence X-RAY 3zni M Reference
       Region 3zni M 36-37 disorder
       Region 3zni M 38-427 order
Seq 38-344 Hetero tetramer : IID00262Complex
 Evidence X-RAY 3pfv A Reference
       Region 3pfv A 38-43 disorder
       Region 3pfv A 44-344 order
 Evidence X-RAY 3pfv B Reference
       Region 3pfv B 38-39 disorder
       Region 3pfv B 40-344 order
Seq 39-426 Monomer :
 Evidence X-RAY 3vgo A Reference
       Region 3vgo A 39-42 disorder
       Region 3vgo A 43-92 order
       Region 3vgo A 93-98 disorder
       Region 3vgo A 99-133 order
       Region 3vgo A 134-137 disorder
       Region 3vgo A 138-339 order
       Region 3vgo A 340-426 disorder
 Evidence X-RAY 3vgo B Reference
       Region 3vgo B 39-42 disorder
       Region 3vgo B 43-93 order
       Region 3vgo B 94-98 disorder
       Region 3vgo B 99-133 order
       Region 3vgo B 134-137 disorder
       Region 3vgo B 138-311 order
       Region 3vgo B 312-313 disorder
       Region 3vgo B 314-339 order
       Region 3vgo B 340-357 disorder
       Region 3vgo B 358-365 order
       Region 3vgo B 366-426 disorder
 Evidence X-RAY 3vgo C Reference
       Region 3vgo C 39-42 disorder
       Region 3vgo C 43-92 order
       Region 3vgo C 93-98 disorder
       Region 3vgo C 99-133 order
       Region 3vgo C 134-137 disorder
       Region 3vgo C 138-311 order
       Region 3vgo C 312-313 disorder
       Region 3vgo C 314-338 order
       Region 3vgo C 339-357 disorder
       Region 3vgo C 358-365 order
       Region 3vgo C 366-426 disorder
Seq 351-426 Monomer :
 Evidence NMR 2ldr A Reference
       Region 2ldr A 351-426 order
Seq 902-912 Hetero trimer : Q96B97
 Evidence X-RAY 2bz8 C Reference
       Region 2bz8 C 902-912 order
Seq 902-912 Hetero dimer : Q9Y5K6
 Evidence X-RAY 2j6f C Reference
       Region 2j6f C 902-904 disorder
       Region 2j6f C 905-912 order
Seq 904-911 Hetero hexamer : O55043
 Evidence X-RAY 2ak5 D Reference
       Region 2ak5 D 904-911 order
Seq 924-973 Hetero dimer : P0CH28
 Evidence X-RAY 2oob A Reference
       Region 2oob A 924-928 disorder
       Region 2oob A 929-972 order
       Region 2oob A 973-973 disorder
Seq 924-973 Monomer :
 Evidence X-RAY 2ooa A Reference
       Region 2ooa A 924-931 disorder
       Region 2ooa A 932-973 order
 Evidence X-RAY 2ooa B Reference
       Region 2ooa B 924-931 disorder
       Region 2ooa B 932-973 order
 Evidence NMR 2jnh A Reference
       Region 2jnh A 926-927 disorder
       Region 2jnh A 928-971 order
       Region 2jnh A 928-930 high_rmsd
       Region 2jnh A 971-971 high_rmsd
Seq 931-970 Homo dimer :
 Evidence NMR 2do6 A Reference
       Region 2do6 A 931-970 order
 Evidence NMR 2do6 B Reference
       Region 2do6 B 931-970 order
Seqphosphorylation
    282-282 Phosphoserine; by PKC/PRKCQ
    363-363 Phosphotyrosine
    476-476 Phosphoserine
    480-480 Phosphoserine
    484-484 Phosphoserine
    521-521 Phosphoserine
    525-525 Phosphoserine
    529-529 Phosphoserine
    634-634 Phosphoserine
    665-665 Phosphotyrosine
    709-709 Phosphotyrosine
    889-889 Phosphotyrosine
 
Prediction
DICHOT
Disorder 1-37,428-932,970-982
Known Domain 38-427,933-969
SCOPe RPS-Blast
     3buxB2 39-169 6e-55 a.48.1.1 N-terminal domain of cbl (N-cbl)
     3vrnA2 171-255 2e-35 a.39.1.0 automated matches
     3vrnA3 256-342 1e-39 d.93.1.0 automated matches
     1fbvA4 348-426 9e-30 g.44.1.1 Acute promyelocytic leukaemia proto-on...
SCOP Hmmer
     2cblA2 41-169 7.3e-59 a.48.1.1 N-terminal domai...
     2cblA1 171-255 3.6e-40 a.39.1.7 alpha-Actinin
     2cblA3 256-342 2.1e-49 d.93.1.1 Abl tyrosine ki...
     1fbvA4 349-426 5.4e-45 g.44.1.1 Acute promyeloc...
Pfam RPS-Blast
     PF02262 42-167 1e-54 CBL proto-oncogene N-termina...
     PF02761 171-254 1e-32 CBL proto-oncogene N-termin...
     PF02762 256-341 4e-41 CBL proto-oncogene N-termin...
     PF14447 373-421 9e-19 Prokaryotic RING finger fam...
     PF12851 473-871 5e-06 Oxygenase domain of the 2OG...
Pfam Hmmer
    PF02262 42-167 3.2e-57 CBL proto-oncogene N-termin...
    PF02761 171-254 5.8e-43 CBL proto-oncogene N-termi...
    PF02762 256-341 2.7e-48 CBL proto-oncogene N-termi...
    PF14447 373-421 5e-16 Prokaryotic RING finger fami...