Search Keyword:


Search option:


IID00327  E3 ubiquitin-protein ligase UHRF1 (Homo sapiens) Q96T88
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
793
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-76 Monomer :
 Evidence X-RAY 2faz A Reference
       Region 2faz A 1-76 order
 Evidence X-RAY 2faz B Reference
       Region 2faz B 1-72 order
       Region 2faz B 73-76 disorder
Seq 126-285 Hetero dimer : Q3BDD9
 Evidence NMR 2l3r A Reference
       Region 2l3r A 126-285 order
       Region 2l3r A 168-174 high_rmsd
Seq 126-285 Homo dimer :
 Evidence X-RAY 4qqd A Reference
       Region 4qqd A 126-132 disorder
       Region 4qqd A 133-162 order
       Region 4qqd A 163-178 disorder
       Region 4qqd A 179-282 order
       Region 4qqd A 283-285 disorder
 Evidence X-RAY 4qqd B Reference
       Region 4qqd B 126-127 order
       Region 4qqd B 128-132 disorder
       Region 4qqd B 133-162 order
       Region 4qqd B 163-177 disorder
       Region 4qqd B 178-281 order
       Region 4qqd B 282-285 disorder
Seq 126-285 Hetero dimer : IID00088Complex
 Evidence X-RAY 3db3 A Reference
       Region 3db3 A 126-126 disorder
       Region 3db3 A 127-162 order
       Region 3db3 A 163-179 disorder
       Region 3db3 A 180-283 order
       Region 3db3 A 284-285 disorder
Seq 126-285 Monomer :
 Evidence X-RAY 3db4 A Reference
       Region 3db4 A 126-128 disorder
       Region 3db4 A 129-132 order
       Region 3db4 A 133-133 disorder
       Region 3db4 A 134-161 order
       Region 3db4 A 162-179 disorder
       Region 3db4 A 180-261 order
       Region 3db4 A 262-262 disorder
       Region 3db4 A 263-283 order
       Region 3db4 A 284-285 disorder
Seq 134-367 Hetero hexamer : IID00239Complex
 Evidence X-RAY 3ask A Reference
       Region 3ask A 134-163 order
       Region 3ask A 164-164 disorder
       Region 3ask A 165-173 order
       Region 3ask A 174-178 disorder
       Region 3ask A 179-325 order
       Region 3ask A 326-327 disorder
       Region 3ask A 328-344 order
       Region 3ask A 345-346 disorder
       Region 3ask A 347-364 order
       Region 3ask A 365-367 disorder
 Evidence X-RAY 3ask B Reference
       Region 3ask B 134-162 order
       Region 3ask B 163-164 disorder
       Region 3ask B 165-173 order
       Region 3ask B 174-179 disorder
       Region 3ask B 180-344 order
       Region 3ask B 345-347 disorder
       Region 3ask B 348-363 order
       Region 3ask B 364-367 disorder
 Evidence X-RAY 3ask C Reference
       Region 3ask C 134-162 order
       Region 3ask C 163-164 disorder
       Region 3ask C 165-173 order
       Region 3ask C 174-178 disorder
       Region 3ask C 179-302 order
       Region 3ask C 303-367 disorder
 Evidence X-RAY 3ask D Reference
       Region 3ask D 134-161 order
       Region 3ask D 162-164 disorder
       Region 3ask D 165-173 order
       Region 3ask D 174-178 disorder
       Region 3ask D 179-301 order
       Region 3ask D 302-367 disorder
 Evidence X-RAY 4gy5 A Reference
       Region 4gy5 A 134-162 order
       Region 4gy5 A 163-179 disorder
       Region 4gy5 A 180-364 order
       Region 4gy5 A 365-366 disorder
 Evidence X-RAY 4gy5 B Reference
       Region 4gy5 B 134-162 order
       Region 4gy5 B 163-179 disorder
       Region 4gy5 B 180-344 order
       Region 4gy5 B 345-347 disorder
       Region 4gy5 B 348-363 order
       Region 4gy5 B 364-366 disorder
 Evidence X-RAY 4gy5 C Reference
       Region 4gy5 C 134-162 order
       Region 4gy5 C 163-177 disorder
       Region 4gy5 C 178-302 order
       Region 4gy5 C 303-366 disorder
 Evidence X-RAY 4gy5 D Reference
       Region 4gy5 D 134-161 order
       Region 4gy5 D 162-179 disorder
       Region 4gy5 D 180-301 order
       Region 4gy5 D 302-366 disorder
Seq 134-285,642-657 Hetero dimer :
 Evidence NMR 5iay A Reference
       Region 5iay A 134-285 order
       Region 5iay A 167-174 high_rmsd
 Evidence NMR 5iay B Reference
       Region 5iay B 642-657 order
Seq 296-367 Hetero tetramer : IID00062Complex
 Evidence X-RAY 3zvy A Reference
       Region 3zvy A 296-299 disorder
       Region 3zvy A 300-364 order
       Region 3zvy A 365-367 disorder
 Evidence X-RAY 3zvy B Reference
       Region 3zvy B 296-299 disorder
       Region 3zvy B 300-365 order
       Region 3zvy B 366-367 disorder
Seq 298-366 Hetero dimer :
 Evidence NMR 2lgk A Reference
       Region 2lgk A 298-366 order
       Region 2lgk A 298-299 high_rmsd
Seq 298-366 Hetero dimer :
 Evidence NMR 2lgg A Reference
       Region 2lgg A 298-366 order
       Region 2lgg A 298-303 high_rmsd
       Region 2lgg A 366-366 high_rmsd
Seq 298-366 Hetero dimer :
 Evidence X-RAY 3shb A Reference
       Region 3shb A 298-364 order
       Region 3shb A 365-366 disorder
Seq 298-367 Hetero dimer : IID00239Complex
 Evidence X-RAY 3asl A Reference
       Region 3asl A 298-298 disorder
       Region 3asl A 299-366 order
       Region 3asl A 367-367 disorder
Seq 298-367 Monomer :
 Evidence NMR 2lgl A Reference
       Region 2lgl A 298-366 order
       Region 2lgl A 298-311 high_rmsd
 Evidence X-RAY 3sox A Reference
       Region 3sox A 298-298 disorder
       Region 3sox A 299-363 order
       Region 3sox A 364-367 disorder
 Evidence X-RAY 3sox B Reference
       Region 3sox B 298-298 disorder
       Region 3sox B 299-363 order
       Region 3sox B 364-367 disorder
 Evidence X-RAY 3zvz B Reference
       Region 3zvz B 314-365 order
       Region 3zvz B 366-367 disorder
Seq 298-367 Hetero dimer : IID00062Complex
 Evidence X-RAY 3sou A Reference
       Region 3sou A 298-299 disorder
       Region 3sou A 300-367 order
 Evidence X-RAY 3sou B Reference
       Region 3sou B 298-298 disorder
       Region 3sou B 299-367 order
 Evidence X-RAY 3sow A Reference
       Region 3sow A 298-299 disorder
       Region 3sow A 300-366 order
       Region 3sow A 367-367 disorder
 Evidence X-RAY 3sow B Reference
       Region 3sow B 298-299 disorder
       Region 3sow B 300-364 order
       Region 3sow B 365-367 disorder
Seq 299-364 Hetero trimer : IID00086Complex
 Evidence X-RAY 3t6r A Reference
       Region 3t6r A 299-364 order
 Evidence X-RAY 3t6r B Reference
       Region 3t6r B 299-364 order
Seq 408-643 Monomer :
 Evidence X-RAY 3bi7 A Reference
       Region 3bi7 A 414-483 order
       Region 3bi7 A 484-495 disorder
       Region 3bi7 A 496-617 order
 Evidence X-RAY 3clz A Reference
       Region 3clz A 414-415 disorder
       Region 3clz A 416-617 order
 Evidence X-RAY 3clz B Reference
       Region 3clz B 414-414 disorder
       Region 3clz B 415-617 order
 Evidence X-RAY 3clz C Reference
       Region 3clz C 414-415 disorder
       Region 3clz C 416-617 order
 Evidence X-RAY 3clz D Reference
       Region 3clz D 414-415 disorder
       Region 3clz D 416-617 order
 Evidence X-RAY 3dwh A Reference
       Region 3dwh A 414-483 order
       Region 3dwh A 484-495 disorder
       Region 3dwh A 496-614 order
       Region 3dwh A 615-617 disorder
 Evidence X-RAY 2pb7 A Reference
       Region 2pb7 A 408-408 disorder
       Region 2pb7 A 409-483 order
       Region 2pb7 A 484-493 disorder
       Region 2pb7 A 494-615 order
       Region 2pb7 A 616-643 disorder
Seq 634-665 Hetero dimer : IID00176Complex
 Evidence X-RAY 5c6d C Reference
       Region 5c6d C 634-638 disorder
       Region 5c6d C 639-651 order
       Region 5c6d C 652-665 disorder
 Evidence X-RAY 5c6d D Reference
       Region 5c6d D 634-642 disorder
       Region 5c6d D 643-649 order
       Region 5c6d D 650-665 disorder
Seq 638-678 Hetero tetramer : E7EZF3
 Evidence X-RAY 6b9m D Reference
       Region 6b9m D 638-647 disorder
       Region 6b9m D 648-664 order
       Region 6b9m D 665-678 disorder
Seq 672-793 Monomer :
 Evidence X-RAY 3fl2 A Reference
       Region 3fl2 A 672-674 disorder
       Region 3fl2 A 675-700 order
       Region 3fl2 A 701-703 disorder
       Region 3fl2 A 704-793 order
SeqProS possible 639-651 This region is described to be disordered in the free state. (PubMed=25891992) Hetero dimer : IID00176Complex
       Region 5c6d C 639-651 order
       Region 5c6d D 643-649 order
Seqphosphorylation
    76-76 Phosphoserine
    91-91 Phosphoserine
    95-95 Phosphoserine
    165-165 Phosphoserine
    287-287 Phosphoserine
    298-298 Phosphoserine; by PKA
    368-368 Phosphoserine
    639-639 Phosphoserine; by CDK1
    651-651 Phosphoserine
    707-707 Phosphoserine
    709-709 Phosphoserine
Seqacetylation
    399-399 N6-acetyllysine
    546-546 N6-acetyllysine; alternate
 
Prediction
DICHOT
Disorder 77-133,365-408,616-674
Known Domain 1-76,134-364,409-615,675-793
SCOPe RPS-Blast
     2fazA1 1-76 2e-24 d.15.1.1 1700011n24rik protein
     3zvzB1 314-365 2e-24 g.50.1.0 automated matches
     3fdeA1 414-622 6e-79 b.122.1.12 E3 ubiquitin-protein ligase UHRF1
     1rmdA2 714-783 1e-12 g.44.1.1 Acute promyelocytic leukaemia proto-on...
SCOP Hmmer
     1lm8B_ 1-96 7.4e-21 d.15.1.1 1700011n24rik prot...
     1we9A_ 316-367 6.7e-14 FYVE/PHD zinc finger
     2zkdA1 400-607 1.2e-80 b.122.1.12 E3 ubiquitin-...
     1rmdA2 716-772 2.4e-14 g.44.1.1 Acute promyeloc...
Pfam RPS-Blast
     PF12148 133-284 2e-63 Tandem tudor domain within ...
     PF00628 318-364 2e-09 PHD-finger
     PF02182 417-585 1e-31 SAD/SRA domain
     PF13923 723-762 5e-05 Zinc finger, C3HC4 type (RI...
Pfam Hmmer
    PF00240 3-75 1.8e-20 Ubiquitin family
    PF12148 133-284 2.2e-70 Tandem tudor domain within...
    PF00628 318-365 1.7e-15 PHD-finger
    PF02182 417-585 2.1e-60 SAD/SRA domain