Search Keyword:


Search option:


IID00334
 UniprotQ9UN37
ProteinVacuolar protein sorting-associated protein 4A
GeneVPS4A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
437
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-77 Monomer :
 Evidence NMR 1yxr A Reference
       Region 1yxr A 1-77 order
       Region 1yxr A 1-1 high_rmsd
Seq 1-84 Hetero dimer : IID00253Complex
 Evidence NMR 2jq9 A Reference
       Region 2jq9 A 1-4 disorder
       Region 2jq9 A 5-75 order
       Region 2jq9 A 76-84 disorder
Seq 1-84 Hetero dimer : IID00862Complex
 Evidence NMR 2k3w A Reference
       Region 2k3w A 1-2 disorder
       Region 2k3w A 3-75 order
       Region 2k3w A 76-84 disorder
Seqphosphorylation
    95-95 Phosphoserine
    97-97 Phosphoserine
Seqacetylation
    8-8 N6-acetyllysine
 
Prediction
NeProc
Disorder 54-105,432-437
Order 1-49,106-431
ProS 54-77,101-105,432-437
AlphaFold
Disorder 1-3,78-102,198-203,234-240,258-259,435-437
Order 4-77,103-197,204-233,241-257,260-434
Pfam Hmmer
PF04212 43-72 2.5e-09
PF00004 162-347 5.2e-84
SEG 90-102
Function
Function in SwissProt
(Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).
Biological Process
Diagram with PDB data
VPS4A/CHMP6NMR structure of VPS4A-MIT-CHMP6