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IID00344
 UniprotP26038
ProteinMoesin
GeneMSN
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
577
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-297 Hetero dimer : IID00134Complex
 Evidence X-RAY 1sgh A Reference
       Region 1sgh A 1-3 disorder
       Region 1sgh A 4-297 order
Seq 2-346 Monomer :
 Evidence X-RAY 1e5w A Reference
       Region 1e5w A 2-346 order
Seq 4-297,488-577 Hetero tetramer :
 Evidence X-RAY 1ef1 D This complex is hetero tetramer in the automatic decision, but is actually homo dimer. Reference
       Region 1ef1 D 488-577 order
 Evidence X-RAY 1ef1 C This complex is hetero tetramer in the automatic decision, but is actually homo dimer. Reference
       Region 1ef1 C 488-577 order
 Evidence X-RAY 1ef1 B This complex is hetero tetramer in the automatic decision, but is actually homo dimer. Reference
       Region 1ef1 B 4-297 order
 Evidence X-RAY 1ef1 A This complex is hetero tetramer in the automatic decision, but is actually homo dimer. Reference
       Region 1ef1 A 4-297 order
Seqphosphorylation
    116-116 Phosphotyrosine
    74-74 Phosphoserine
    407-407 Phosphoserine
    527-527 Phosphoserine
    558-558 Phosphothreonine; by ROCK2 and STK10
Seqacetylation
    79-79 N6-acetyllysine
    139-139 N6-acetyllysine
    165-165 N6-acetyllysine
 
Prediction
NeProc
Disorder 470-500,550-577
Order 1-469,501-549
ProS 489-500,550-577
AlphaFold
Disorder 1-2,404-418,452-490,495-501
Order 3-403,419-451,491-494,502-577
Pfam Hmmer
PF00373 7-206 3.5e-137
PF00769 210-577 9.7e-239
SEG 324-352 ,385-406 ,505-517
Function
Function in SwissProt
Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation (PubMed:27405666).