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IID00348
 UniprotQ96CV9
ProteinOptineurin
GeneOPTN
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
577
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 26-103 Hetero tetramer : Q9UHD2
 Evidence X-RAY 5eoa A Reference
       Region 5eoa A 26-29 disorder
       Region 5eoa A 30-101 order
       Region 5eoa A 102-103 disorder
 Evidence X-RAY 5eoa B Reference
       Region 5eoa B 26-29 disorder
       Region 5eoa B 30-102 order
       Region 5eoa B 103-103 disorder
 Evidence X-RAY 5eof A Reference
       Region 5eof A 26-28 disorder
       Region 5eof A 29-102 order
       Region 5eof A 103-103 disorder
 Evidence X-RAY 5eof B Reference
       Region 5eof B 26-28 disorder
       Region 5eof B 29-102 order
       Region 5eof B 103-103 disorder
Seq 169-185 Hetero dimer : IID00346Complex
 Evidence NMR 2lue B Reference
       Region 2lue B 169-185 order
Seq 170-181 Hetero dimer : IID00346Complex
 Evidence X-RAY 3vtw C Reference
       Region 3vtw C 170-176 disorder
       Region 3vtw C 177-181 order
Seq 170-181 Hetero dimer : IID00346Complex
 Evidence X-RAY 3vtw B Reference
       Region 3vtw B 170-176 disorder
       Region 3vtw B 177-181 order
Seq 170-181 Hetero dimer : IID00346Complex
 Evidence X-RAY 3vtv A Reference
       Region 3vtv A 170-176 disorder
       Region 3vtv A 177-181 order
Seq 170-181 Hetero dimer : IID00346Complex
 Evidence X-RAY 3vtw A Reference
       Region 3vtw A 170-176 disorder
       Region 3vtw A 177-181 order
Seq 173-185 Hetero tetramer : Q8TDY2
 Evidence X-RAY 7czm D Reference
       Region 7czm D 173-174 disorder
       Region 7czm D 175-185 order
 Evidence X-RAY 7czm C Reference
       Region 7czm C 173-174 disorder
       Region 7czm C 175-183 order
       Region 7czm C 184-185 disorder
Seq 416-510 Hetero trimer : P0CG48
 Evidence X-RAY 5b83 B Reference
       Region 5b83 B 416-442 disorder
       Region 5b83 B 443-501 order
       Region 5b83 B 502-510 disorder
 Evidence X-RAY 5b83 C Reference
       Region 5b83 C 416-444 disorder
       Region 5b83 C 445-505 order
       Region 5b83 C 506-510 disorder
 Evidence X-RAY 5b83 E Reference
       Region 5b83 E 416-452 disorder
       Region 5b83 E 453-502 order
       Region 5b83 E 503-510 disorder
 Evidence X-RAY 5b83 F Reference
       Region 5b83 F 416-446 disorder
       Region 5b83 F 447-505 order
       Region 5b83 F 506-510 disorder
Seq 548-577 Monomer :
 Evidence NMR 2lo4 A Reference
       Region 2lo4 A 550-577 order
       Region 2lo4 A 550-550 high_rmsd
 Evidence NMR 5aaz A Reference
       Region 5aaz A 548-577 order
       Region 5aaz A 548-549 high_rmsd
SeqProS predicted 169-185 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc; FIR (FIP200-interacting region) motif Hetero dimer : IID00346Complex
       Region 3vtw A 177-181 order
SeqProS predicted 169-185 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc; FIR (FIP200-interacting region) motif Hetero dimer : IID00346Complex
       Region 3vtv A 177-181 order
SeqProS predicted 169-185 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc; FIR (FIP200-interacting region) motif Hetero dimer : IID00346Complex
       Region 2lue B 169-185 order
SeqProS predicted 169-185 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc; FIR (FIP200-interacting region) motif Hetero dimer : IID00346Complex
       Region 3vtw C 177-181 order
SeqProS predicted 169-185 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc; FIR (FIP200-interacting region) motif Hetero dimer : IID00346Complex
       Region 3vtw B 177-181 order
SeqProS predicted 175-185 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc; FIR (FIP200-interacting region) motif Hetero tetramer : Q8TDY2
       Region 7czm C 175-183 order
       Region 7czm D 175-185 order
Seqphosphorylation
    177-177 Phosphoserine; by TBK1
    526-526 Phosphoserine
    198-198 Phosphoserine
    342-342 Phosphoserine
 
Prediction
NeProc
Disorder 1-75,125-132,168-232,275-298,472-481,510-550
Order 76-124,133-167,233-274,299-471,482-509,551-577
ProS 6-13,23-29,36-75,177-198,210-232,275-298,472-481,510-519
AlphaFold
Disorder 1-35,116-135,170-223,270-297,520-552,577-577
Order 36-115,136-169,224-269,298-519,553-576
SEG 105-117 ,423-443
Function
Function in SwissProt
(Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:9488477, PubMed:27538435). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559).
Biological Process
Diagram with PDB data
OPTN/MAP1LC3BLC3B OPTN-LIR Ptot complex structure