Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG
396
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Seq 283-314 Hetero tetramer : IID00338 Complex
Region 4mid A 283-291 disorder
Region 4mid A 292-314 order
Region 2goo D 283-292 disorder
Region 2goo D 293-396 order
Region 2goo A 283-293 disorder
Region 2goo A 294-396 order
Seq 283-396 Hetero hexamer : IID50131 Complex ,
P36894
Region 2h64 A 283-291 disorder
Region 2h64 A 292-396 order
Seq 283-396 Hetero tetramer : P36894
Region 1es7 A 283-292 disorder
Region 1es7 A 293-396 order
Region 1es7 C 283-292 disorder
Region 1es7 C 293-396 order
Region 1rew A 283-293 disorder
Region 1rew A 294-396 order
Region 1rew B 283-293 disorder
Region 1rew B 294-396 order
Region 2qj9 A 283-292 disorder
Region 2qj9 A 293-396 order
Region 2qj9 B 283-293 disorder
Region 2qj9 B 294-396 order
Region 2qja A 283-292 disorder
Region 2qja A 293-396 order
Region 2qja B 283-292 disorder
Region 2qja B 293-396 order
Region 2qjb A 283-293 disorder
Region 2qjb A 294-396 order
Region 2qjb B 283-292 disorder
Region 2qjb B 293-396 order
Seq 283-396 Hetero trimer : Q6NW40
Region 4ui0 B 283-292 disorder
Region 4ui0 B 293-396 order
Region 4ui0 A 283-292 disorder
Region 4ui0 A 293-332 order
Region 4ui0 A 333-335 disorder
Region 4ui0 A 336-396 order
Region 2h62 B 283-293 disorder
Region 2h62 B 294-396 order
Region 2h62 A 283-292 disorder
Region 2h62 A 293-396 order
Seq 283-396 Hetero dimer : Q6NW40
Region 4uhz A 283-292 disorder
Region 4uhz A 293-396 order
Seq 283-396 Hetero trimer : Q96B86
Region 4uhy B 283-291 disorder
Region 4uhy B 292-396 order
Region 4uhy A 283-292 disorder
Region 4uhy A 293-396 order
Region 4ui2 B 283-292 disorder
Region 4ui2 B 293-396 order
Seq 283-396 Hetero dimer : Q6ZVN8
Region 4ui1 A 283-292 disorder
Region 4ui1 A 293-396 order
Region 4ui1 B 283-291 disorder
Region 4ui1 B 292-396 order
Seq 283-305,362-396 Hetero hexamer : IID00577 Complex
Region 4n1d A 283-292 disorder
Region 4n1d A 293-305 order
Region 4n1d A 362-396 order
Seq 283-396 Hetero tetramer : IID50132 Complex
Region 3bk3 B 283-292 disorder
Region 3bk3 B 293-396 order
Region 3bk3 A 283-292 disorder
Region 3bk3 A 293-396 order
Region 1reu A 294-396 order
Region 3bmp A 283-290 disorder
Region 3bmp A 291-396 order
Prediction
Disorder 1-6,30-47,91-99,248-258,264-294
Order 7-29,48-90,100-162,167-247,259-263,295-396
ProS 1-6,30-32,91-99,248-258,264-271
Disorder 1-45,90-95,121-126,158-166,235-242,278-293
Order 46-89,96-120,127-157,167-234,243-277,294-396
Function
Function in SwissProt
Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).