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IID00355
 UniprotP10600
ProteinTransforming growth factor beta-3
GeneTGFB3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
412
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 259-269 Hetero hexamer : P06756,P18564
 Evidence X-RAY 4um9 F Reference
       Region 4um9 F 259-269 order
 Evidence X-RAY 4um9 E Reference
       Region 4um9 E 259-259 disorder
       Region 4um9 E 260-269 order
Seq 301-412 Hetero hexamer : P01861
 Evidence X-RAY 3eo1 F Reference
       Region 3eo1 F 301-412 order
 Evidence X-RAY 3eo1 C Reference
       Region 3eo1 C 301-412 order
Seq 301-412 Homo dimer :
 Evidence X-RAY 1tgk A Reference
       Region 1tgk A 301-412 order
 Evidence X-RAY 1tgj A Reference
       Region 1tgj A 301-412 order
Seq 301-412 Hetero hexamer : IID00413Complex,IID00414Complex
 Evidence X-RAY 2pjy A Reference
       Region 2pjy A 301-412 order
Seq 301-412 Hetero hexamer : P01861
 Evidence X-RAY 3eo1 L Reference
       Region 3eo1 L 301-412 order
 Evidence X-RAY 3eo1 I Reference
       Region 3eo1 I 301-412 order
Seq 301-412 Hetero tetramer : IID00414Complex
 Evidence X-RAY 1ktz A Reference
       Region 1ktz A 301-312 disorder
       Region 1ktz A 313-354 order
       Region 1ktz A 355-372 disorder
       Region 1ktz A 373-412 order
SeqProS verified 355-372 This region is ordered when interacts with another chain of this protein. Homo dimer :
       Region 1tgk A 301-412 order
       Region 1tgj A 301-412 order
       Region 1ktz A 355-372 disorder
SeqProS verified 355-372 This region is ordered when interacts with another chain of this protein. Hetero hexamer : IID00413Complex,IID00414Complex
       Region 2pjy A 301-412 order
       Region 1ktz A 355-372 disorder
SeqProS verified 355-372 This region is ordered when interacts with another chain of this protein. Hetero hexamer : P01861
       Region 3eo1 C 301-412 order
       Region 1ktz A 355-372 disorder
 
Prediction
NeProc
Disorder 1-6,30-34,80-125,238-310
Order 7-29,35-79,126-177,182-237,311-412
ProS 1-6,30-34,80-90,98-125,238-281,302-310
AlphaFold
Disorder 1-2,14-30,86-98,113-126,140-144,228-234,236-236,238-243,255-273,290-313,350-357,359-360,364-364,372-375
Order 3-13,31-85,99-112,127-139,145-227,235-235,237-237,244-254,274-289,314-349,358-358,361-363,365-371,376-412
Pfam Hmmer
PF00688 27-255 1.2e-72
PF00019 312-412 2e-46
SEG 21-30 ,77-90
Function
Function in SwissProt
Involved in embryogenesis and cell differentiation.