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IID00358
 UniprotO15047
ProteinHistone-lysine N-methyltransferase SETD1A
GeneSETD1A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1707
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 89-197 Monomer :
 Evidence X-RAY 3s8s A Reference
       Region 3s8s A 89-195 order
       Region 3s8s A 196-197 disorder
Seq 1488-1502 Hetero dimer : IID00377Complex
 Evidence X-RAY 3uvn D Reference
       Region 3uvn D 1492-1499 order
       Region 3uvn D 1500-1502 disorder
 Evidence X-RAY 3uvn B Reference
       Region 3uvn B 1492-1500 order
       Region 3uvn B 1501-1502 disorder
 Evidence X-RAY 4ewr C Reference
       Region 4ewr C 1488-1489 disorder
       Region 4ewr C 1490-1499 order
       Region 4ewr C 1500-1501 disorder
Seqphosphorylation
    1103-1103 Phosphoserine
    915-915 Phosphoserine
    565-565 Phosphoserine
    508-508 Phosphoserine
    464-464 Phosphoserine
    459-459 Phosphoserine
 
Prediction
NeProc
Disorder 1-14,189-781,833-1411,1517-1540
Order 15-188,782-832,1412-1516,1541-1548,1554-1707
ProS 211-220,238-260,268-286,306-311,364-371,486-495,503-508,557-561,580-597,634-640,649-662,669-675,684-690,699-706,713-738,747-768,873-895,960-965,1142-1153,1293-1313,1353-1358,1390-1405,1535-1540
AlphaFold
Disorder 1-18,27-37,44-81,196-491,495-495,499-678,689-689,691-788,836-1406,1412-1415,1454-1458,1468-1468,1473-1486,1513-1534,1536-1536,1540-1540,1544-1544,1546-1566
Order 19-26,38-43,82-195,492-494,496-498,679-688,690-690,789-835,1407-1411,1416-1453,1459-1467,1469-1472,1487-1512,1535-1535,1537-1539,1541-1543,1545-1545,1567-1707
Pfam Hmmer
PF00076 96-167 0.00034
PF00856 1562-1691 4.1e-50
SEG 209-226 ,278-295 ,315-357 ,426-455 ,457-473 ,592-627 ,635-654 ,698-721 ,767-781 ,838-857 ,919-930 ,962-992 ,1000-1015 ,1031-1069 ,1071-1101 ,1123-1166 ,1177-1194 ,1226-1261 ,1308-1326 ,1331-1351 ,1359-1419 ,1531-1545 ,1557-1572
Function
Function in SwissProt
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression (PubMed:12670868). May play a role in synaptic function and the development of neurons (PubMed:31197650).