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IID00378
 UniprotP63165
ProteinSmall ubiquitin-related modifier 1
GeneSUMO1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
101
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-97 Hetero dimer : IID00136Complex
 Evidence NMR 2asq A Reference
       Region 2asq A 1-20 disorder
       Region 2asq A 21-97 order
Seq 1-97 Hetero dimer : Q13569
 Evidence X-RAY 1wyw B Reference
       Region 1wyw B 1-18 disorder
       Region 1wyw B 19-97 order
Seq 1-97 Hetero dimer : IID00398Complex
 Evidence NMR 2kqs A Reference
       Region 2kqs A 1-97 order
       Region 2kqs A 1-16 high_rmsd
Seq 1-97 Hetero trimer : IID00104Complex,IID00397Complex
 Evidence X-RAY 3kyc D Reference
       Region 3kyc D 1-18 disorder
       Region 3kyc D 19-97 order
 Evidence X-RAY 3kyd D Reference
       Region 3kyd D 1-19 disorder
       Region 3kyd D 20-94 order
Seq 1-97 Hetero dimer :
 Evidence X-RAY 3rzw C Reference
       Region 3rzw C 1-19 disorder
       Region 3rzw C 20-94 order
       Region 3rzw C 95-97 disorder
Seq 1-97 Hetero dimer :
 Evidence X-RAY 3rzw D Reference
       Region 3rzw D 1-19 disorder
       Region 3rzw D 20-97 order
Seq 1-97 Hetero dimer : P63279
 Evidence X-RAY 2pe6 B Reference
       Region 2pe6 B 1-20 disorder
       Region 2pe6 B 21-94 order
       Region 2pe6 B 95-97 disorder
 Evidence X-RAY 8odr B Reference
       Region 8odr B 18-20 disorder
       Region 8odr B 21-97 order
Seq 1-101 Hetero dimer : P08393
 Evidence NMR 6jxu A Reference
       Region 6jxu A 1-20 disorder
       Region 6jxu A 21-97 order
       Region 6jxu A 98-101 disorder
 Evidence NMR 6jxv A Reference
       Region 6jxv A 1-20 disorder
       Region 6jxv A 21-97 order
       Region 6jxv A 98-101 disorder
Seq 1-101 Hetero dimer : IID00092Complex
 Evidence NMR 2n1a A Reference
       Region 2n1a A 1-101 order
Seq 1-101 Hetero dimer : IID00151Complex
 Evidence NMR 2las A Reference
       Region 2las A 1-19 disorder
       Region 2las A 20-97 order
       Region 2las A 98-101 disorder
Seq 1-101 Hetero trimer : IID00104Complex
 Evidence X-RAY 1y8r C Reference
       Region 1y8r C 1-13 disorder
       Region 1y8r C 14-97 order
 Evidence X-RAY 1y8r F Reference
       Region 1y8r F 1-13 disorder
       Region 1y8r F 14-97 order
 Evidence X-RAY 6xog C Reference
       Region 6xog C 1-21 disorder
       Region 6xog C 22-41 order
       Region 6xog C 42-43 disorder
       Region 6xog C 44-49 order
       Region 6xog C 50-59 disorder
       Region 6xog C 60-83 order
       Region 6xog C 84-85 disorder
       Region 6xog C 86-97 order
       Region 6xog C 98-101 disorder
Seq 1-101 Monomer :
 Evidence NMR 1a5r A Reference
       Region 1a5r A 1-101 order
       Region 1a5r A 1-18 high_rmsd
       Region 1a5r A 97-101 high_rmsd
 Evidence NMR 2mw5 A Reference
       Region 2mw5 A 1-97 order
       Region 2mw5 A 1-19 high_rmsd
       Region 2mw5 A 95-97 high_rmsd
 Evidence NMR 2n1v A Reference
       Region 2n1v A 1-97 order
       Region 2n1v A 1-17 high_rmsd
       Region 2n1v A 97-97 high_rmsd
 Evidence NMR 5b7a A Reference
       Region 5b7a A 1-97 order
       Region 5b7a A 1-17 high_rmsd
       Region 5b7a A 97-97 high_rmsd
 Evidence NMR 5ghd A Reference
       Region 5ghd A 1-97 order
       Region 5ghd A 1-18 high_rmsd
       Region 5ghd A 96-97 high_rmsd
 Evidence NMR 6j4i A Reference
       Region 6j4i A 1-97 order
       Region 6j4i A 1-18 high_rmsd
       Region 6j4i A 95-97 high_rmsd
Seq 1-101 Hetero trimer : IID00104Complex
 Evidence X-RAY 6xoh C Reference
       Region 6xoh C 1-21 disorder
       Region 6xoh C 22-38 order
       Region 6xoh C 39-43 disorder
       Region 6xoh C 44-54 order
       Region 6xoh C 55-60 disorder
       Region 6xoh C 61-71 order
       Region 6xoh C 72-84 disorder
       Region 6xoh C 85-97 order
       Region 6xoh C 98-101 disorder
 Evidence X-RAY 6xoi C Reference
       Region 6xoi C 1-20 disorder
       Region 6xoi C 21-38 order
       Region 6xoi C 39-60 disorder
       Region 6xoi C 61-72 order
       Region 6xoi C 73-86 disorder
       Region 6xoi C 87-97 order
       Region 6xoi C 98-101 disorder
Seq 2-7 Hetero tetramer : O95714
 Evidence X-RAY 6ww3 B Reference
       Region 6ww3 B 2-7 order
 Evidence X-RAY 6ww3 A Reference
       Region 6ww3 A 2-7 order
Seq 2-97 Hetero dimer : IID00900Complex
 Evidence X-RAY 4wjn A Reference
       Region 4wjn A 17-17 disorder
       Region 4wjn A 18-94 order
       Region 4wjn A 95-97 disorder
 Evidence X-RAY 4wjo A Reference
       Region 4wjo A 17-17 disorder
       Region 4wjo A 18-94 order
       Region 4wjo A 95-97 disorder
 Evidence X-RAY 6uyp A Reference
       Region 6uyp A 17-18 disorder
       Region 6uyp A 19-93 order
       Region 6uyp A 94-97 disorder
 Evidence X-RAY 6uyq A Reference
       Region 6uyq A 17-18 disorder
       Region 6uyq A 19-93 order
       Region 6uyq A 94-97 disorder
 Evidence X-RAY 6uyr A Reference
       Region 6uyr A 17-18 disorder
       Region 6uyr A 19-93 order
       Region 6uyr A 94-97 disorder
 Evidence X-RAY 6uyt A Reference
       Region 6uyt A 17-18 disorder
       Region 6uyt A 19-93 order
       Region 6uyt A 94-97 disorder
 Evidence X-RAY 6uyv A Reference
       Region 6uyv A 17-17 disorder
       Region 6uyv A 18-94 order
       Region 6uyv A 95-97 disorder
 Evidence X-RAY 8djh A Reference
       Region 8djh A 2-9 disorder
       Region 8djh A 10-94 order
       Region 8djh A 95-97 disorder
 Evidence X-RAY 8dji A Reference
       Region 8dji A 2-18 disorder
       Region 8dji A 19-93 order
       Region 8dji A 94-97 disorder
Seq 17-97 Hetero dimer :
 Evidence X-RAY 4wjq A Reference
       Region 4wjq A 17-19 disorder
       Region 4wjq A 20-97 order
Seq 17-97 Hetero dimer :
 Evidence X-RAY 4wjq C Reference
       Region 4wjq C 17-17 disorder
       Region 4wjq C 18-93 order
       Region 4wjq C 94-97 disorder
Seq 17-97 Hetero dimer :
 Evidence X-RAY 4wjp A Reference
       Region 4wjp A 17-18 disorder
       Region 4wjp A 19-97 order
Seq 17-97 Hetero tetramer :
 Evidence X-RAY 6v7q C Reference
       Region 6v7q C 17-93 order
       Region 6v7q C 94-97 disorder
 Evidence X-RAY 6v7q A Reference
       Region 6v7q A 17-19 disorder
       Region 6v7q A 20-95 order
       Region 6v7q A 96-97 disorder
Seq 17-97 Hetero tetramer :
 Evidence X-RAY 6uyz C Reference
       Region 6uyz C 17-95 order
       Region 6uyz C 96-97 disorder
 Evidence X-RAY 6uyz A Reference
       Region 6uyz A 17-19 disorder
       Region 6uyz A 20-96 order
       Region 6uyz A 97-97 disorder
Seq 17-97 Hetero tetramer :
 Evidence X-RAY 6v7p C Reference
       Region 6v7p C 17-19 disorder
       Region 6v7p C 20-95 order
       Region 6v7p C 96-97 disorder
 Evidence X-RAY 6v7p A Reference
       Region 6v7p A 17-20 disorder
       Region 6v7p A 21-94 order
       Region 6v7p A 95-97 disorder
Seq 17-97 Hetero tetramer :
 Evidence X-RAY 6v7r C Reference
       Region 6v7r C 17-19 disorder
       Region 6v7r C 20-93 order
       Region 6v7r C 94-97 disorder
 Evidence X-RAY 6v7r A Reference
       Region 6v7r A 17-93 order
       Region 6v7r A 94-97 disorder
Seq 17-97 Hetero tetramer :
 Evidence X-RAY 6v7s C Reference
       Region 6v7s C 17-20 disorder
       Region 6v7s C 21-93 order
       Region 6v7s C 94-97 disorder
 Evidence X-RAY 6v7s A Reference
       Region 6v7s A 17-93 order
       Region 6v7s A 94-97 disorder
Seq 17-97 Hetero dimer :
 Evidence X-RAY 6uyy A Reference
       Region 6uyy A 17-18 disorder
       Region 6uyy A 19-97 order
Seq 17-97 Hetero tetramer : IID00900Complex
 Evidence X-RAY 6uyo A Reference
       Region 6uyo A 17-18 disorder
       Region 6uyo A 19-93 order
       Region 6uyo A 94-97 disorder
 Evidence X-RAY 6uyo C Reference
       Region 6uyo C 17-18 disorder
       Region 6uyo C 19-94 order
       Region 6uyo C 95-97 disorder
 Evidence X-RAY 6uys A Reference
       Region 6uys A 17-19 disorder
       Region 6uys A 20-94 order
       Region 6uys A 95-97 disorder
 Evidence X-RAY 6uys C Reference
       Region 6uys C 17-18 disorder
       Region 6uys C 19-94 order
       Region 6uys C 95-97 disorder
 Evidence X-RAY 6uyu A Reference
       Region 6uyu A 17-18 disorder
       Region 6uyu A 19-97 order
 Evidence X-RAY 6uyu C Reference
       Region 6uyu C 17-18 disorder
       Region 6uyu C 19-94 order
       Region 6uyu C 95-97 disorder
Seq 17-97 Hetero dimer :
 Evidence X-RAY 4wjp C Reference
       Region 4wjp C 17-17 disorder
       Region 4wjp C 18-94 order
       Region 4wjp C 95-97 disorder
Seq 17-97 Hetero tetramer :
 Evidence X-RAY 6uyx C Reference
       Region 6uyx C 17-18 disorder
       Region 6uyx C 19-97 order
 Evidence X-RAY 6uyx A Reference
       Region 6uyx A 17-18 disorder
       Region 6uyx A 19-95 order
       Region 6uyx A 96-97 disorder
Seq 18-97 Hetero dimer : Q9HC62
 Evidence X-RAY 1tgz B Reference
       Region 1tgz B 18-19 disorder
       Region 1tgz B 20-97 order
 Evidence X-RAY 5aek B Reference
       Region 5aek B 20-97 order
 Evidence X-RAY 5aek T Reference
       Region 5aek T 20-97 order
 Evidence X-RAY 5aek V Reference
       Region 5aek V 20-97 order
 Evidence X-RAY 5aek X Reference
       Region 5aek X 20-97 order
 Evidence X-RAY 5aek D Reference
       Region 5aek D 20-97 order
 Evidence X-RAY 5aek F Reference
       Region 5aek F 20-97 order
 Evidence X-RAY 5aek H Reference
       Region 5aek H 20-20 disorder
       Region 5aek H 21-97 order
 Evidence X-RAY 5aek J Reference
       Region 5aek J 20-97 order
 Evidence X-RAY 5aek L Reference
       Region 5aek L 20-20 disorder
       Region 5aek L 21-97 order
 Evidence X-RAY 5aek N Reference
       Region 5aek N 20-97 order
 Evidence X-RAY 5aek P Reference
       Region 5aek P 20-97 order
 Evidence X-RAY 5aek R Reference
       Region 5aek R 20-97 order
Seq 18-97 Hetero tetramer : IID00151Complex,P63279
 Evidence X-RAY 1z5s B Reference
       Region 1z5s B 18-19 disorder
       Region 1z5s B 20-97 order
 Evidence X-RAY 3uip B Reference
       Region 3uip B 18-19 disorder
       Region 3uip B 20-97 order
Seq 18-97 Hetero dodecamer : P46060,Q9HC62
 Evidence X-RAY 2io2 B Reference
       Region 2io2 B 18-22 disorder
       Region 2io2 B 23-97 order
Seq 18-97 Hetero dimer :
 Evidence X-RAY 5elj B Reference
       Region 5elj B 18-18 disorder
       Region 5elj B 19-93 order
       Region 5elj B 94-97 disorder
Seq 20-97 Hetero dimer : P63280
 Evidence X-RAY 2uyz B Reference
       Region 2uyz B 20-96 order
       Region 2uyz B 97-97 disorder
 Evidence X-RAY 2vrr B Reference
       Region 2vrr B 20-97 order
Seq 20-101 Hetero trimer : P46060,Q9P0U3
 Evidence X-RAY 2iy0 B Reference
       Region 2iy0 B 20-21 disorder
       Region 2iy0 B 22-97 order
       Region 2iy0 B 98-101 disorder
Seq 20-101 Hetero dimer : Q9P0U3
 Evidence X-RAY 2g4d B Reference
       Region 2g4d B 20-97 order
 Evidence X-RAY 2g4d D Reference
       Region 2g4d D 20-97 order
 Evidence X-RAY 2iy1 B Reference
       Region 2iy1 B 20-101 order
 Evidence X-RAY 2iy1 D Reference
       Region 2iy1 D 20-101 order
Seq 21-97 Hetero dimer : P61085
 Evidence X-RAY 2bf8 B Reference
       Region 2bf8 B 21-97 order
Seq 21-97 Hetero dimer : P19893
 Evidence NMR 6k5t A Reference
       Region 6k5t A 21-97 order
Seq 61-68 Hetero tetramer : Q6V1X1
 Evidence X-RAY 6eot H Reference
       Region 6eot H 61-68 order
 Evidence X-RAY 6eot F Reference
       Region 6eot F 61-68 order
 Evidence X-RAY 6eot E Reference
       Region 6eot E 61-68 order
Seq 61-68 Hetero tetramer : Q6V1X1
 Evidence X-RAY 6eop D Reference
       Region 6eop D 61-68 order
 Evidence X-RAY 6eop E Reference
       Region 6eop E 61-68 order
 Evidence X-RAY 6eop F Reference
       Region 6eop F 61-68 order
 Evidence X-RAY 6eot J Reference
       Region 6eot J 61-68 order
 Evidence X-RAY 6eot L Reference
       Region 6eot L 61-68 order
Seq 61-68 Hetero tetramer : Q6V1X1
 Evidence X-RAY 6eot C Reference
       Region 6eot C 61-68 order
Seq 61-75 Hetero hexamer : Q6V1X1
 Evidence X-RAY 6trw F Reference
       Region 6trw F 61-70 order
       Region 6trw F 71-75 disorder
 Evidence X-RAY 6trw E Reference
       Region 6trw E 61-70 order
       Region 6trw E 71-75 disorder
 Evidence X-RAY 6trw D Reference
       Region 6trw D 61-70 order
       Region 6trw D 71-75 disorder
SeqProS verified 2-7 Hetero tetramer : O95714
       Region 6ww3 A 2-7 order
       Region 6ww3 B 2-7 order
       Region 1wyw B 1-18 disorder
Seqphosphorylation
    2-2 Phosphoserine
    9-9 Phosphoserine
    32-32 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-19
Order 20-101
AlphaFold
Disorder 1-19,94-101
Order 20-93
Pfam Hmmer
PF00240 25-95 2.1e-18
Function
Function in SwissProt
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).
Biological Process
See also
Diagram with PDB data
DAXX/SUMO1Phosphorylation of SUMO-interacting motif by CK2 enhances Daxx SUMO binding activity