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IID00379  Histone-lysine N-methyltransferase 2A (Homo sapiens) Q03164
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
3969
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 6-25 Hetero dimer : IID00404Complex
 Evidence X-RAY 4gq6 B Reference
       Region 4gq6 B 6-15 order
 Evidence X-RAY 3u85 B Reference
       Region 3u85 B 6-13 order
       Region 3u85 B 14-25 disorder
Seq 6-16,24-39,103-153 Hetero trimer : IID00404Complex,IID00408Complex
 Evidence X-RAY 3u88 M Reference
       Region 3u88 M 6-16 order
       Region 3u88 M 24-39 order
       Region 3u88 M 103-135 order
       Region 3u88 M 136-153 disorder
 Evidence X-RAY 3u88 N Reference
       Region 3u88 N 6-16 order
       Region 3u88 N 24-39 order
       Region 3u88 N 103-134 order
       Region 3u88 N 135-153 disorder
Seq 110-160 Hetero dimer : IID00408Complex
 Evidence NMR 2mtn A Reference
       Region 2mtn A 110-121 disorder
       Region 2mtn A 122-154 order
       Region 2mtn A 122-126 high_rmsd
       Region 2mtn A 135-145 high_rmsd
       Region 2mtn A 154-155 high_rmsd
       Region 2mtn A 155-160 disorder
Seq 140-160 Hetero dimer : IID00408Complex
 Evidence NMR 2msr A Reference
       Region 2msr A 140-160 order
Seq 1143-1214 Monomer :
 Evidence NMR 2j2s A Reference
       Region 2j2s A 1143-1214 order
       Region 2j2s A 1143-1148 high_rmsd
       Region 2j2s A 1204-1214 high_rmsd
 Evidence NMR 2jyi A Reference
       Region 2jyi A 1147-1203 order
       Region 2jyi A 1147-1150 high_rmsd
       Region 2jyi A 1201-1203 high_rmsd
 Evidence NMR 2kkf A Reference
       Region 2kkf A 1147-1203 order
       Region 2kkf A 1147-1149 high_rmsd
       Region 2kkf A 1202-1203 high_rmsd
 Evidence X-RAY 4nw3 A Reference
       Region 4nw3 A 1147-1149 disorder
       Region 4nw3 A 1150-1200 order
       Region 4nw3 A 1201-1204 disorder
Seq 1564-1628 Monomer :
 Evidence NMR 2kyu A Reference
       Region 2kyu A 1564-1628 order
       Region 2kyu A 1564-1565 high_rmsd
       Region 2kyu A 1628-1628 high_rmsd
Seq 1566-1784 Hetero dimer : IID00062Complex
 Evidence X-RAY 3lqi A Reference
       Region 3lqi A 1566-1702 order
       Region 3lqi A 1703-1703 disorder
       Region 3lqi A 1704-1778 order
       Region 3lqi A 1779-1784 disorder
 Evidence X-RAY 3lqi B Reference
       Region 3lqi B 1566-1702 order
       Region 3lqi B 1703-1703 disorder
       Region 3lqi B 1704-1779 order
       Region 3lqi B 1780-1784 disorder
 Evidence X-RAY 3lqi C Reference
       Region 3lqi C 1566-1663 order
       Region 3lqi C 1664-1665 disorder
       Region 3lqi C 1666-1784 order
 Evidence X-RAY 3lqj A Reference
       Region 3lqj A 1566-1664 order
       Region 3lqj A 1665-1665 disorder
       Region 3lqj A 1666-1779 order
       Region 3lqj A 1780-1784 disorder
 Evidence X-RAY 3lqj B Reference
       Region 3lqj B 1566-1663 order
       Region 3lqj B 1664-1665 disorder
       Region 3lqj B 1666-1778 order
       Region 3lqj B 1779-1784 disorder
Seq 1566-1784 Monomer :
 Evidence X-RAY 3lqh A Reference
       Region 3lqh A 1566-1664 order
       Region 3lqh A 1665-1665 disorder
       Region 3lqh A 1666-1702 order
       Region 3lqh A 1703-1703 disorder
       Region 3lqh A 1704-1778 order
       Region 3lqh A 1779-1784 disorder
Seq 1585-1628 Hetero dimer : Q9UNP9
 Evidence NMR 2ku7 A Reference
       Region 2ku7 A 1585-1602 disorder
       Region 2ku7 A 1585-1600 high_rmsd
       Region 2ku7 A 1603-1619 order
       Region 2ku7 A 1620-1628 disorder
       Region 2ku7 A 1621-1628 high_rmsd
Seq 2840-2858 Hetero dimer : IID00092Complex
 Evidence NMR 2lxs B Reference
       Region 2lxs B 2840-2858 order
       Region 2lxs B 2840-2842 high_rmsd
Seq 2840-2858 Hetero trimer : IID00092Complex,IID00442Complex
 Evidence NMR 2lxt B Reference
       Region 2lxt B 2840-2858 order
       Region 2lxt B 2840-2842 high_rmsd
Seq 2840-2869 Hetero trimer : IID50008Complex
 Evidence NMR 2agh C Reference
       Region 2agh C 2840-2869 order
       Region 2agh C 2840-2842 high_rmsd
       Region 2agh C 2860-2869 high_rmsd
Seq 3755-3771 Hetero dimer : IID00377Complex
 Evidence X-RAY 4esg D Reference
       Region 4esg D 3755-3770 order
       Region 4esg D 3771-3771 disorder
 Evidence X-RAY 4esg C Reference
       Region 4esg C 3755-3770 order
       Region 4esg C 3771-3771 disorder
Seq 3761-3770 Hetero trimer : IID00377Complex
 Evidence X-RAY 3p4f C Reference
       Region 3p4f C 3761-3761 disorder
       Region 3p4f C 3762-3770 order
Seq 3762-3776 Hetero dimer : IID00377Complex
 Evidence X-RAY 3eg6 C Reference
       Region 3eg6 C 3762-3770 order
       Region 3eg6 C 3771-3773 disorder
 Evidence X-RAY 3emh B Reference
       Region 3emh B 3764-3769 order
       Region 3emh B 3770-3776 disorder
Seq 3785-3969 Monomer :
 Evidence X-RAY 5f5e A Reference
       Region 5f5e A 3813-3813 disorder
       Region 5f5e A 3814-3945 order
       Region 5f5e A 3946-3953 disorder
       Region 5f5e A 3954-3969 order
 Evidence X-RAY 2w5y A Reference
       Region 2w5y A 3785-3792 disorder
       Region 2w5y A 3793-3946 order
       Region 2w5y A 3947-3953 disorder
       Region 2w5y A 3954-3969 order
Seq 3785-3969 Hetero dimer : P68433
 Evidence X-RAY 2w5z A Reference
       Region 2w5z A 3785-3789 disorder
       Region 2w5z A 3790-3969 order
Seq 3813-3969 Hetero tetramer : IID00387Complex,Q9UBL3
 Evidence X-RAY 5f6l A Reference
       Region 5f6l A 3813-3813 disorder
       Region 5f6l A 3814-3950 order
       Region 5f6l A 3951-3953 disorder
       Region 5f6l A 3954-3969 order
SeqProS verified 13-15 Hetero dimer : IID00404Complex
       Region 4gq6 B 6-15 order
       Region 3u85 B 14-25 disorder
SeqProS verified 1620-1628 The region is disordered in the complex with CyP33 RRM domain. Hetero dimer : IID00062Complex
       Region 3lqi A 1566-1702 order
       Region 3lqi B 1566-1702 order
       Region 3lqi C 1566-1663 order
       Region 3lqj A 1566-1664 order
       Region 3lqj B 1566-1663 order
       Region 2ku7 A 1620-1628 disorder
SeqProS verified 1620-1628 The region is ordered in the free state but disordered in the complex with CyP33 RRM domain. :
       Region 2kyu A 1564-1628 order
       Region 2ku7 A 1620-1628 disorder
SeqProS verified 1620-1628 The region is disordered in the complex with CyP33 RRM domain. :
       Region 3lqh A 1566-1664 order
       Region 2ku7 A 1620-1628 disorder
SeqProS possible 2842-2858 This region is described to be disordered in the absence of CBP KIX domain (PubMed=15738986 ). Hetero dimer : IID00092Complex
       Region 2lxs B 2840-2858 order
SeqProS possible 2842-2858 This region is described to be disordered in the absence of CBP KIX domain (PubMed=15738986 ). Hetero trimer : IID00092Complex,IID00442Complex
       Region 2lxt B 2840-2858 order
SeqProS possible 2842-2858 This region is described to be disordered in the absence of CBP KIX domain (PubMed=15738986 ). Hetero trimer : IID50008Complex
       Region 2agh C 2840-2869 order
SeqProS possible 3762-3770 This region is described to be disordered in the free state. (PubMed=20716525) Hetero trimer : IID00377Complex
       Region 3p4f C 3762-3770 order
SeqProS possible 3764-3769 This region is described to be disordered in the free state. (PubMed=20716525) Hetero dimer : IID00377Complex
       Region 3emh B 3764-3769 order
Seqphosphorylation
    153-153 Phosphoserine
    197-197 Phosphoserine
    518-518 Phosphoserine
    680-680 Phosphoserine
    840-840 Phosphothreonine
    926-926 Phosphoserine
    1056-1056 Phosphoserine
    1837-1837 Phosphoserine
    1845-1845 Phosphothreonine
    1858-1858 Phosphoserine
    2098-2098 Phosphoserine
    2147-2147 Phosphothreonine
    2151-2151 Phosphoserine
    2201-2201 Phosphoserine
    2525-2525 Phosphothreonine
    2611-2611 Phosphoserine
    2796-2796 Phosphoserine
    2955-2955 Phosphoserine
    3036-3036 Phosphoserine
    3372-3372 Phosphothreonine
    3511-3511 Phosphoserine
    3515-3515 Phosphoserine
    3527-3527 Phosphoserine
Seqacetylation
    239-239 N6-acetyllysine
    373-373 N6-acetyllysine
    636-636 N6-acetyllysine
    1130-1130 N6-acetyllysine
    1235-1235 N6-acetyllysine
    2958-2958 N6-acetyllysine
    3462-3462 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-1145,1207-1433,1779-1871,2099-3705,3744-3792
Known Domain 1146-1206,1434-1778,1872-1977,2021-2098,3793-3969
Cryptic Domain 1978-2020,3706-3743
SCOPe RPS-Blast
     3pt6A1 1151-1198 1e-17 g.95.1.1 Zn finger domain from DNA methyltra...
     1wevA1 1481-1543 7e-08 g.50.1.2 Death associated transcription fact...
     1we9A1 1569-1627 1e-06 g.50.1.2 Death associated transcription fact...
     2f69A2 3809-3956 2e-41 b.85.7.1 Dim-5
SCOP Hmmer
     1wesA_ 1428-1480 5.6e-06 FYVE/PHD zinc finger
     1wevA_ 1467-1537 9.1e-14 FYVE/PHD zinc finger
     1wepA_ 1567-1635 1.2e-12 FYVE/PHD zinc finger
     1jspB_ 1704-1768 5.7e-08 Bromodomain
     1fp0A1 1929-1979 0.00095 g.50.1.2 Death associa...
     1ml9A_ 3824-3966 5.2e-50 b.85.7.1 Dim-5
Pfam RPS-Blast
     PF02008 1150-1194 3e-16 CXXC zinc finger domain
     PF15485 1210-1360 9e-04 Domain of unknown functio...
     PF00628 1482-1533 6e-07 PHD-finger
     PF00628 1572-1625 2e-05 PHD-finger
     PF13771 1900-1978 9e-26 PHD-like zinc-binding dom...
     PF05964 2024-2071 1e-09 F/Y-rich N-terminus
     PF05965 3670-3748 6e-20 F/Y rich C-terminus
     PF00856 3840-3944 2e-07 SET domain
Pfam Hmmer
    PF02008 1148-1194 1.6e-16 CXXC zinc finger domain
    PF00628 1481-1533 6.1e-12 PHD-finger
    PF00628 1569-1626 5.3e-12 PHD-finger
    PF13771 1900-1978 9.6e-14 PHD-like zinc-binding do...
    PF05964 2024-2071 2.5e-19 F/Y-rich N-terminus
    PF05965 3669-3748 4.7e-25 F/Y rich C-terminus
    PF00856 3840-3944 6.7e-25 SET domain