Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG
4911
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Region 2ysm A 342-439 order
Region 2yuk A 1631-1713 order
Region 2yuk A 1631-1634 high_rmsd
Region 2yuk A 1709-1713 high_rmsd
Seq 4703-4717 Hetero dimer : IID00377 Complex
Region 3uvl B 4707-4715 order
Region 3uvl B 4716-4717 disorder
Region 4ery D 4703-4716 order
Region 5f59 A 4757-4889 order
Region 5f59 A 4890-4895 disorder
Region 5f59 A 4896-4910 order
Seq 4757-4911 Hetero tetramer : IID00387 Complex ,
Q6NXT2 ,
Q9UBL3
Region 5f6k C 4757-4888 order
Region 5f6k C 4889-4896 disorder
Region 5f6k C 4897-4911 order
Seq 4757-4911 Hetero heptamer : IID00387 Complex ,
Q6NXT2 ,
Q9UBL3
Region 5f6k E 4757-4886 order
Region 5f6k E 4887-4895 disorder
Region 5f6k E 4896-4911 order
Region 5f6k C 4757-4888 order
Region 5f6k C 4889-4896 disorder
Region 5f6k C 4897-4911 order
Seq 4757-4911 Hetero trimer : IID00387 Complex ,
Q9UBL3
Region 5f6k E 4757-4886 order
Region 5f6k E 4887-4895 disorder
Region 5f6k E 4896-4911 order
1508-1508 N6-acetyllysine
1772-1772 N6-acetyllysine
2009-2009 N6-acetyllysine
2802-2802 N6-acetyllysine
2809-2809 N6-acetyllysine
2832-2832 N6-acetyllysine
2867-2867 N6-acetyllysine
3714-3714 N6-acetyllysine
Prediction
Disorder 1-130,163-220,498-937,1146-1657,1685-1758,1787-3172,3201-3236,3272-3390,3433-3887,3896-3911,3928-4002,4011-4017,4025-4072,4120-4193,4224-4232,4241-4243,4253-4361,4366-4377,4718-4755
Order 131-162,221-497,938-1140,1658-1684,1759-1786,3173-3200,3237-3271,3391-3432,3888-3895,3912-3927,4003-4010,4018-4024,4077-4119,4194-4223,4233-4240,4244-4248,4362-4365,4378-4717,4756-4911
ProS 30-42,62-73,174-182,194-201,506-518,841-850,855-869,877-905,917-918,922-926,1146-1152,1171-1189,1209-1214,1236-1246,1254-1270,1275-1304,1325-1330,1356-1377,1401-1406,1461-1464,1509-1515,1523-1529,1636-1657,1690-1703,1734-1739,1844-1848,1962-1969,2297-2300,2386-2393,2592-2603,2703-2725,2733-2774,2917-2920,3085-3095,3123-3126,3385-3389,3716-3720,3777-3783,3829-3834,3841-3844,3877-3887,3896-3911,3928-3935,3968-4002,4011-4017,4029-4072,4139-4151,4159-4163,4177-4184,4241-4243,4350-4361,4366-4377,4718-4729,4747-4755
PF00628 1011-1057 2.8e-09
PF00628 1086-1139 2.7e-05
PF00505 1649-1712 0.00083
PF05964 4550-4603 4.2e-20
PF05965 4606-4693 2.8e-34
PF00856 4765-4893 1.2e-46
SEG 10-32
,73-85
,663-672
,759-795
,894-917
,1195-1207
,1343-1354
,1404-1416
,1441-1452
,1533-1549
,1567-1581
,1780-1787
,1834-1843
,1850-1865
,1867-1880
,1883-1894
,2173-2187
,2381-2400
,2473-2490
,2703-2727
,2934-2948
,3011-3030
,3039-3071
,3162-3171
,3179-3201
,3396-3418
,3463-3490
,3601-3615
,3774-3793
,3866-3875
,3893-3910
,4002-4016
,4021-4042
,4296-4316
,4419-4426
,4868-4876
Function
Function in SwissProt
Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.