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IID00389
UniprotQ8NEZ4
ProteinHistone-lysine N-methyltransferase 2C
GeneKMT2C
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
4911
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 342-439 Monomer :
 Evidence NMR 2ysm A Reference
       Region 2ysm A 342-439 order
Seq 1631-1713 Monomer :
 Evidence NMR 2yuk A Reference
       Region 2yuk A 1631-1713 order
       Region 2yuk A 1631-1634 high_rmsd
       Region 2yuk A 1709-1713 high_rmsd
Seq 4703-4717 Hetero dimer : IID00377Complex
 Evidence X-RAY 3uvl B Reference
       Region 3uvl B 4707-4715 order
       Region 3uvl B 4716-4717 disorder
 Evidence X-RAY 4ery D Reference
       Region 4ery D 4703-4716 order
Seq 4757-4910 Monomer :
 Evidence X-RAY 5f59 A Reference
       Region 5f59 A 4757-4889 order
       Region 5f59 A 4890-4895 disorder
       Region 5f59 A 4896-4910 order
Seq 4757-4911 Hetero tetramer : IID00387Complex,Q6NXT2,Q9UBL3
 Evidence X-RAY 5f6k C Reference
       Region 5f6k C 4757-4888 order
       Region 5f6k C 4889-4896 disorder
       Region 5f6k C 4897-4911 order
Seq 4757-4911 Hetero heptamer : IID00387Complex,Q6NXT2,Q9UBL3
 Evidence X-RAY 5f6k E Reference
       Region 5f6k E 4757-4886 order
       Region 5f6k E 4887-4895 disorder
       Region 5f6k E 4896-4911 order
 Evidence X-RAY 5f6k C Reference
       Region 5f6k C 4757-4888 order
       Region 5f6k C 4889-4896 disorder
       Region 5f6k C 4897-4911 order
Seq 4757-4911 Hetero trimer : IID00387Complex,Q9UBL3
 Evidence X-RAY 5f6k E Reference
       Region 5f6k E 4757-4886 order
       Region 5f6k E 4887-4895 disorder
       Region 5f6k E 4896-4911 order
Seqphosphorylation
    28-28 Phosphoserine
    46-46 Phosphoserine
    89-89 Phosphoserine
    113-113 Phosphoserine
    200-200 Phosphoserine
    854-854 Phosphoserine
    1301-1301 Phosphoserine
    1987-1987 Phosphoserine
    2828-2828 Phosphoserine
    3758-3758 Phosphoserine
    4034-4034 Phosphoserine
    4267-4267 Phosphoserine
Seqacetylation
    758-758 N6-acetyllysine
    1508-1508 N6-acetyllysine
    1772-1772 N6-acetyllysine
    2009-2009 N6-acetyllysine
    2802-2802 N6-acetyllysine
    2809-2809 N6-acetyllysine
    2832-2832 N6-acetyllysine
    2867-2867 N6-acetyllysine
    3714-3714 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-130,163-220,498-937,1146-1657,1685-1758,1787-3172,3201-3236,3272-3390,3433-3887,3896-3911,3928-4002,4011-4017,4025-4072,4120-4193,4224-4232,4241-4243,4253-4361,4366-4377,4718-4755
Order 131-162,221-497,938-1140,1658-1684,1759-1786,3173-3200,3237-3271,3391-3432,3888-3895,3912-3927,4003-4010,4018-4024,4077-4119,4194-4223,4233-4240,4244-4248,4362-4365,4378-4717,4756-4911
ProS 30-42,62-73,174-182,194-201,506-518,841-850,855-869,877-905,917-918,922-926,1146-1152,1171-1189,1209-1214,1236-1246,1254-1270,1275-1304,1325-1330,1356-1377,1401-1406,1461-1464,1509-1515,1523-1529,1636-1657,1690-1703,1734-1739,1844-1848,1962-1969,2297-2300,2386-2393,2592-2603,2703-2725,2733-2774,2917-2920,3085-3095,3123-3126,3385-3389,3716-3720,3777-3783,3829-3834,3841-3844,3877-3887,3896-3911,3928-3935,3968-4002,4011-4017,4029-4072,4139-4151,4159-4163,4177-4184,4241-4243,4350-4361,4366-4377,4718-4729,4747-4755
Pfam Hmmer
PF00628 343-391 2e-10
PF00628 392-438 1.9e-10
PF00628 466-520 4.2e-06
PF00628 959-1010 5.6e-13
PF00628 1011-1057 2.8e-09
PF00628 1086-1139 2.7e-05
PF00505 1649-1712 0.00083
PF05964 4550-4603 4.2e-20
PF05965 4606-4693 2.8e-34
PF00856 4765-4893 1.2e-46
SEG 10-32 ,73-85 ,663-672 ,759-795 ,894-917 ,1195-1207 ,1343-1354 ,1404-1416 ,1441-1452 ,1533-1549 ,1567-1581 ,1780-1787 ,1834-1843 ,1850-1865 ,1867-1880 ,1883-1894 ,2173-2187 ,2381-2400 ,2473-2490 ,2703-2727 ,2934-2948 ,3011-3030 ,3039-3071 ,3162-3171 ,3179-3201 ,3396-3418 ,3463-3490 ,3601-3615 ,3774-3793 ,3866-3875 ,3893-3910 ,4002-4016 ,4021-4042 ,4296-4316 ,4419-4426 ,4868-4876
Function
Function in SwissProt
Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.