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IID00390
 UniprotQ92831
ProteinHistone acetyltransferase KAT2B
GeneKAT2B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
832
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 493-658 Homo dimer :
 Evidence X-RAY 4nsq C Reference
       Region 4nsq C 493-502 order
       Region 4nsq C 503-506 disorder
       Region 4nsq C 507-652 order
       Region 4nsq C 653-658 disorder
 Evidence X-RAY 4nsq B Reference
       Region 4nsq B 493-502 order
       Region 4nsq B 503-506 disorder
       Region 4nsq B 507-652 order
       Region 4nsq B 653-658 disorder
 Evidence X-RAY 4nsq D Reference
       Region 4nsq D 493-502 order
       Region 4nsq D 503-506 disorder
       Region 4nsq D 507-652 order
       Region 4nsq D 653-658 disorder
 Evidence X-RAY 4nsq A Reference
       Region 4nsq A 493-502 order
       Region 4nsq A 503-506 disorder
       Region 4nsq A 507-652 order
       Region 4nsq A 653-658 disorder
Seq 493-658 Monomer :
 Evidence X-RAY 1cm0 A Reference
       Region 1cm0 A 493-653 order
       Region 1cm0 A 654-658 disorder
 Evidence X-RAY 1cm0 B Reference
       Region 1cm0 B 493-652 order
       Region 1cm0 B 653-658 disorder
Seq 715-831 Homo dimer :
 Evidence X-RAY 5lvr B Reference
       Region 5lvr B 715-722 disorder
       Region 5lvr B 723-830 order
       Region 5lvr B 831-831 disorder
 Evidence X-RAY 5lvr A Reference
       Region 5lvr A 715-723 disorder
       Region 5lvr A 724-831 order
 Evidence X-RAY 5fe8 B Reference
       Region 5fe8 B 715-723 disorder
       Region 5fe8 B 724-831 order
 Evidence X-RAY 5fe8 A Reference
       Region 5fe8 A 715-723 disorder
       Region 5fe8 A 724-831 order
 Evidence X-RAY 5fe6 B Reference
       Region 5fe6 B 715-721 disorder
       Region 5fe6 B 722-831 order
 Evidence X-RAY 5fe6 A Reference
       Region 5fe6 A 715-722 disorder
       Region 5fe6 A 723-831 order
 Evidence X-RAY 5fe5 B Reference
       Region 5fe5 B 715-722 disorder
       Region 5fe5 B 723-831 order
 Evidence X-RAY 5fe5 A Reference
       Region 5fe5 A 715-723 disorder
       Region 5fe5 A 724-831 order
 Evidence X-RAY 5fe4 B Reference
       Region 5fe4 B 715-723 disorder
       Region 5fe4 B 724-831 order
 Evidence X-RAY 5fe4 A Reference
       Region 5fe4 A 715-723 disorder
       Region 5fe4 A 724-831 order
 Evidence X-RAY 5fe3 B Reference
       Region 5fe3 B 715-722 disorder
       Region 5fe3 B 723-831 order
 Evidence X-RAY 5fe3 A Reference
       Region 5fe3 A 715-722 disorder
       Region 5fe3 A 723-831 order
 Evidence X-RAY 5fe2 B Reference
       Region 5fe2 B 715-724 disorder
       Region 5fe2 B 725-831 order
 Evidence X-RAY 5fe2 A Reference
       Region 5fe2 A 715-724 disorder
       Region 5fe2 A 725-831 order
 Evidence X-RAY 5fdz B Reference
       Region 5fdz B 715-724 disorder
       Region 5fdz B 725-830 order
       Region 5fdz B 831-831 disorder
 Evidence X-RAY 5fdz A Reference
       Region 5fdz A 715-723 disorder
       Region 5fdz A 724-830 order
       Region 5fdz A 831-831 disorder
Seq 715-832 Monomer :
 Evidence NMR 1zs5 A Reference
       Region 1zs5 A 719-832 order
 Evidence NMR 1wum A Reference
       Region 1wum A 719-832 order
 Evidence NMR 1wug A Reference
       Region 1wug A 719-832 order
 Evidence NMR 1n72 A Reference
       Region 1n72 A 719-832 order
 Evidence X-RAY 5mkx B Reference
       Region 5mkx B 715-724 disorder
       Region 5mkx B 725-831 order
 Evidence X-RAY 5mkx A Reference
       Region 5mkx A 715-725 disorder
       Region 5mkx A 726-831 order
 Evidence X-RAY 5lvq B Reference
       Region 5lvq B 715-722 disorder
       Region 5lvq B 723-830 order
       Region 5lvq B 831-831 disorder
 Evidence X-RAY 5lvq A Reference
       Region 5lvq A 715-723 disorder
       Region 5lvq A 724-831 order
 Evidence X-RAY 3gg3 B Reference
       Region 3gg3 B 715-724 disorder
       Region 3gg3 B 725-828 order
       Region 3gg3 B 829-831 disorder
 Evidence X-RAY 3gg3 A Reference
       Region 3gg3 A 715-724 disorder
       Region 3gg3 A 725-831 order
 Evidence X-RAY 5fe9 B Reference
       Region 5fe9 B 715-722 disorder
       Region 5fe9 B 723-831 order
 Evidence X-RAY 5fe9 A Reference
       Region 5fe9 A 715-722 disorder
       Region 5fe9 A 723-831 order
 Evidence X-RAY 5fe7 B Reference
       Region 5fe7 B 715-722 disorder
       Region 5fe7 B 723-830 order
       Region 5fe7 B 831-831 disorder
 Evidence X-RAY 5fe7 A Reference
       Region 5fe7 A 715-722 disorder
       Region 5fe7 A 723-831 order
 Evidence X-RAY 5fe1 B Reference
       Region 5fe1 B 715-722 disorder
       Region 5fe1 B 723-831 order
 Evidence X-RAY 5fe1 A Reference
       Region 5fe1 A 715-723 disorder
       Region 5fe1 A 724-831 order
 Evidence X-RAY 5fe0 B Reference
       Region 5fe0 B 715-723 disorder
       Region 5fe0 B 724-831 order
 Evidence X-RAY 5fe0 A Reference
       Region 5fe0 A 715-723 disorder
       Region 5fe0 A 724-831 order
Seq 719-832 Hetero dimer : IID50143Complex
 Evidence NMR 2rnw A Reference
       Region 2rnw A 719-832 order
Seq 719-832 Hetero dimer : IID50143Complex
 Evidence NMR 2rnx A Reference
       Region 2rnx A 719-832 order
Seq 719-832 Hetero dimer : P04610
 Evidence NMR 1jm4 B Reference
       Region 1jm4 B 719-832 order
 
Prediction
NeProc
Disorder 1-76,365-471
Order 77-116,120-364,472-832
ProS 9-13,69-76,365-368,379-397,438-456,467-471
AlphaFold
Disorder 1-73,116-130,208-212,370-449,461-481,712-723,831-832
Order 74-115,131-207,213-369,450-460,482-711,724-830
Pfam Hmmer
PF06466 75-327 5.3e-186
PF00583 546-623 5.4e-14
PF00439 728-815 3.5e-40
SEG 4-73 ,480-491 ,662-678
Function
Function in SwissProt
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (PubMed:8945521). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (PubMed:8945521). Also acetylates non-histone proteins, such as ACLY, PLK4, RRP9/U3-55K and TBX5 (PubMed:9707565, PubMed:10675335, PubMed:27796307, PubMed:23932781, PubMed:26867678, PubMed:29174768). Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A (PubMed:8684459). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing (PubMed:26867678). Also acetylates spermidine (PubMed:27389534).
(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.