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IID00392
 UniprotQ99549
ProteinM-phase phosphoprotein 8
GeneMPHOSPH8
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
860
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 55-116 Hetero dimer : IID00088Complex
 Evidence X-RAY 3qo2 A Reference
       Region 3qo2 A 55-114 order
       Region 3qo2 A 115-116 disorder
 Evidence X-RAY 3qo2 B Reference
       Region 3qo2 B 55-56 disorder
       Region 3qo2 B 57-115 order
       Region 3qo2 B 116-116 disorder
 Evidence X-RAY 3qo2 C Reference
       Region 3qo2 C 55-55 disorder
       Region 3qo2 C 56-114 order
       Region 3qo2 C 115-116 disorder
 Evidence X-RAY 3qo2 D Reference
       Region 3qo2 D 55-55 disorder
       Region 3qo2 D 56-114 order
       Region 3qo2 D 115-116 disorder
Seq 55-116 Hetero octamer : IID00088Complex
 Evidence X-RAY 3r93 D Reference
       Region 3r93 D 55-55 disorder
       Region 3r93 D 56-114 order
       Region 3r93 D 115-116 disorder
 Evidence X-RAY 3r93 C Reference
       Region 3r93 C 55-56 disorder
       Region 3r93 C 57-114 order
       Region 3r93 C 115-116 disorder
 Evidence X-RAY 3r93 B Reference
       Region 3r93 B 55-56 disorder
       Region 3r93 B 57-114 order
       Region 3r93 B 115-116 disorder
 Evidence X-RAY 3r93 A Reference
       Region 3r93 A 55-56 disorder
       Region 3r93 A 57-114 order
       Region 3r93 A 115-116 disorder
Seq 55-116 Hetero dimer : IID00336Complex
 Evidence X-RAY 3svm A Reference
       Region 3svm A 55-55 disorder
       Region 3svm A 56-115 order
       Region 3svm A 116-116 disorder
Seq 55-116 Monomer :
 Evidence X-RAY 3lwe A Reference
       Region 3lwe A 55-115 order
       Region 3lwe A 116-116 disorder
 Evidence X-RAY 3lwe B Reference
       Region 3lwe B 55-113 order
       Region 3lwe B 114-116 disorder
Seqphosphorylation
    454-454 Phosphothreonine
    51-51 Phosphoserine
    85-85 Phosphoserine
    136-136 Phosphoserine
    138-138 Phosphoserine
    144-144 Phosphothreonine
    149-149 Phosphoserine; by CDK1
    403-403 Phosphoserine
    400-400 Phosphoserine
    392-392 Phosphoserine
    385-385 Phosphothreonine; by CDK1
    334-334 Phosphothreonine; by CDK1
    319-319 Phosphoserine
    279-279 Phosphoserine
    272-272 Phosphoserine
    266-266 Phosphoserine
    192-192 Phosphoserine
    189-189 Phosphoserine
    188-188 Phosphoserine
    164-164 Phosphoserine; by CDK1
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-61,136-199,228-450
Order 62-135,200-227,451-860
ProS 18-22,28-33,56-61,136-144,241-263,283-285,296-301,353-362,409-416,422-450
AlphaFold
Disorder 1-58,97-97,115-505,507-543,547-550,552-565,589-591,737-741,743-743,745-745,754-762,765-765,767-835,837-848,858-860
Order 59-96,98-114,506-506,544-546,551-551,566-588,592-736,742-742,744-744,746-753,763-764,766-766,836-836,849-857
Pfam Hmmer
PF00385 59-109 7.8e-19
PF00023 666-698 8.7e-09
SEG 26-36 ,151-156 ,163-185 ,205-234 ,253-268
Function
Function in SwissProt
Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).