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IID00404
 UniprotO00255
ProteinMenin
GeneMEN1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
610
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-462 Homo dimer :
 Evidence X-RAY 7uj4 B Reference
       Region 7uj4 B 1-1 disorder
       Region 7uj4 B 2-53 order
       Region 7uj4 B 54-72 disorder
       Region 7uj4 B 73-200 order
       Region 7uj4 B 201-206 disorder
       Region 7uj4 B 207-386 order
       Region 7uj4 B 387-401 disorder
       Region 7uj4 B 402-462 order
 Evidence X-RAY 7uj4 A Reference
       Region 7uj4 A 1-2 disorder
       Region 7uj4 A 3-53 order
       Region 7uj4 A 54-73 disorder
       Region 7uj4 A 74-200 order
       Region 7uj4 A 201-206 disorder
       Region 7uj4 A 207-383 order
       Region 7uj4 A 384-401 disorder
       Region 7uj4 A 402-462 order
 Evidence X-RAY 8e90 B Reference
       Region 8e90 B 1-1 disorder
       Region 8e90 B 2-52 order
       Region 8e90 B 53-65 disorder
       Region 8e90 B 66-387 order
       Region 8e90 B 388-400 disorder
       Region 8e90 B 401-462 order
 Evidence X-RAY 8e90 A Reference
       Region 8e90 A 1-1 disorder
       Region 8e90 A 2-52 order
       Region 8e90 A 53-65 disorder
       Region 8e90 A 66-387 order
       Region 8e90 A 388-400 disorder
       Region 8e90 A 401-462 order
Seq 1-459,520-584 Hetero tetramer :
 Evidence X-RAY 6s2k B Reference
       Region 6s2k B 1-2 disorder
       Region 6s2k B 3-53 order
       Region 6s2k B 54-66 disorder
       Region 6s2k B 67-385 order
       Region 6s2k B 386-401 disorder
       Region 6s2k B 402-459 order
       Region 6s2k B 520-520 order
       Region 6s2k B 521-547 disorder
       Region 6s2k B 548-581 order
       Region 6s2k B 582-584 disorder
 Evidence X-RAY 6s2k A Reference
       Region 6s2k A 1-2 disorder
       Region 6s2k A 3-54 order
       Region 6s2k A 55-64 disorder
       Region 6s2k A 65-385 order
       Region 6s2k A 386-401 disorder
       Region 6s2k A 402-459 order
       Region 6s2k A 520-522 order
       Region 6s2k A 523-547 disorder
       Region 6s2k A 548-581 order
       Region 6s2k A 582-584 disorder
Seq 1-53,74-386,398-459,520-584 Hetero tetramer :
 Evidence X-RAY 7o9t A Reference
       Region 7o9t A 1-53 order
       Region 7o9t A 74-133 order
       Region 7o9t A 134-136 disorder
       Region 7o9t A 137-386 order
       Region 7o9t A 398-400 disorder
       Region 7o9t A 401-459 order
       Region 7o9t A 520-548 disorder
       Region 7o9t A 549-582 order
       Region 7o9t A 583-584 disorder
Seq 1-53,74-386,398-459,520-584 Hetero tetramer :
 Evidence X-RAY 7o9z A Reference
       Region 7o9z A 1-53 order
       Region 7o9z A 74-130 order
       Region 7o9z A 131-131 disorder
       Region 7o9z A 132-386 order
       Region 7o9z A 398-400 disorder
       Region 7o9z A 401-459 order
       Region 7o9z A 520-521 order
       Region 7o9z A 522-547 disorder
       Region 7o9z A 548-582 order
       Region 7o9z A 583-584 disorder
Seq 1-53,74-459,520-584 Hetero trimer :
 Evidence X-RAY 7oa9 A Reference
       Region 7oa9 A 1-53 order
       Region 7oa9 A 74-132 order
       Region 7oa9 A 133-136 disorder
       Region 7oa9 A 137-385 order
       Region 7oa9 A 386-401 disorder
       Region 7oa9 A 402-459 order
       Region 7oa9 A 520-521 order
       Region 7oa9 A 522-548 disorder
       Region 7oa9 A 549-582 order
       Region 7oa9 A 583-584 disorder
Seq 1-53,74-386,398-459,520-584 Hetero tetramer :
 Evidence X-RAY 7o9x A Reference
       Region 7o9x A 1-53 order
       Region 7o9x A 74-133 order
       Region 7o9x A 134-137 disorder
       Region 7o9x A 138-386 order
       Region 7o9x A 398-400 disorder
       Region 7o9x A 401-459 order
       Region 7o9x A 520-520 order
       Region 7o9x A 521-547 disorder
       Region 7o9x A 548-582 order
       Region 7o9x A 583-584 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 5dd9 A Reference
       Region 5dd9 A 1-1 disorder
       Region 5dd9 A 2-53 order
       Region 5dd9 A 74-386 order
       Region 5dd9 A 399-459 order
       Region 5dd9 A 537-548 disorder
       Region 5dd9 A 549-588 order
       Region 5dd9 A 589-593 disorder
Seq 1-53,74-386,399-459,549-593 Hetero tetramer :
 Evidence X-RAY 4og4 A Reference
       Region 4og4 A 1-1 disorder
       Region 4og4 A 2-53 order
       Region 4og4 A 74-386 order
       Region 4og4 A 399-459 order
       Region 4og4 A 549-588 order
       Region 4og4 A 589-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 5db0 A Reference
       Region 5db0 A 1-1 disorder
       Region 5db0 A 2-53 order
       Region 5db0 A 74-386 order
       Region 5db0 A 399-459 order
       Region 5db0 A 537-548 disorder
       Region 5db0 A 549-588 order
       Region 5db0 A 589-593 disorder
Seq 1-53,74-386,399-459,549-593 Hetero tetramer :
 Evidence X-RAY 4og7 A Reference
       Region 4og7 A 1-1 disorder
       Region 4og7 A 2-53 order
       Region 4og7 A 74-386 order
       Region 4og7 A 399-459 order
       Region 4og7 A 549-587 order
       Region 4og7 A 588-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 5ddf A Reference
       Region 5ddf A 1-1 disorder
       Region 5ddf A 2-53 order
       Region 5ddf A 74-386 order
       Region 5ddf A 399-459 order
       Region 5ddf A 537-548 disorder
       Region 5ddf A 549-586 order
       Region 5ddf A 587-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 4gq3 A Reference
       Region 4gq3 A 1-1 disorder
       Region 4gq3 A 2-53 order
       Region 4gq3 A 74-386 order
       Region 4gq3 A 399-459 order
       Region 4gq3 A 537-548 disorder
       Region 4gq3 A 549-588 order
       Region 4gq3 A 589-593 disorder
Seq 1-53,74-386,399-459,549-593 Hetero tetramer :
 Evidence X-RAY 4og5 A Reference
       Region 4og5 A 1-1 disorder
       Region 4og5 A 2-53 order
       Region 4og5 A 74-386 order
       Region 4og5 A 399-459 order
       Region 4og5 A 549-588 order
       Region 4og5 A 589-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 5db3 A Reference
       Region 5db3 A 1-1 disorder
       Region 5db3 A 2-53 order
       Region 5db3 A 74-386 order
       Region 5db3 A 399-459 order
       Region 5db3 A 537-548 disorder
       Region 5db3 A 549-588 order
       Region 5db3 A 589-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 5db1 A Reference
       Region 5db1 A 1-1 disorder
       Region 5db1 A 2-53 order
       Region 5db1 A 74-386 order
       Region 5db1 A 399-459 order
       Region 5db1 A 537-548 disorder
       Region 5db1 A 549-588 order
       Region 5db1 A 589-593 disorder
Seq 1-53,74-386,399-459,549-593 Hetero tetramer :
 Evidence X-RAY 4og8 A Reference
       Region 4og8 A 1-1 disorder
       Region 4og8 A 2-53 order
       Region 4og8 A 74-386 order
       Region 4og8 A 399-459 order
       Region 4og8 A 549-588 order
       Region 4og8 A 589-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 4x5z A Reference
       Region 4x5z A 1-1 disorder
       Region 4x5z A 2-53 order
       Region 4x5z A 74-386 order
       Region 4x5z A 399-459 order
       Region 4x5z A 537-548 disorder
       Region 4x5z A 549-588 order
       Region 4x5z A 589-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 5dda A Reference
       Region 5dda A 1-1 disorder
       Region 5dda A 2-53 order
       Region 5dda A 74-386 order
       Region 5dda A 399-459 order
       Region 5dda A 537-548 disorder
       Region 5dda A 549-587 order
       Region 5dda A 588-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 5dde A Reference
       Region 5dde A 1-1 disorder
       Region 5dde A 2-53 order
       Region 5dde A 74-386 order
       Region 5dde A 399-459 order
       Region 5dde A 537-548 disorder
       Region 5dde A 549-588 order
       Region 5dde A 589-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 4x5y A Reference
       Region 4x5y A 1-1 disorder
       Region 4x5y A 2-53 order
       Region 4x5y A 74-386 order
       Region 4x5y A 399-459 order
       Region 4x5y A 537-548 disorder
       Region 4x5y A 549-589 order
       Region 4x5y A 590-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 6opj A Reference
       Region 6opj A 1-1 disorder
       Region 6opj A 2-53 order
       Region 6opj A 74-386 order
       Region 6opj A 399-459 order
       Region 6opj A 537-537 order
       Region 6opj A 538-548 disorder
       Region 6opj A 549-588 order
       Region 6opj A 589-593 disorder
Seq 1-53,74-386,399-459,549-593 Hetero tetramer :
 Evidence X-RAY 4og6 A Reference
       Region 4og6 A 1-1 disorder
       Region 4og6 A 2-53 order
       Region 4og6 A 74-386 order
       Region 4og6 A 399-459 order
       Region 4og6 A 549-588 order
       Region 4og6 A 589-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 4gpq A Reference
       Region 4gpq A 1-1 disorder
       Region 4gpq A 2-53 order
       Region 4gpq A 74-386 order
       Region 4gpq A 399-459 order
       Region 4gpq A 537-548 disorder
       Region 4gpq A 549-589 order
       Region 4gpq A 590-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 6bxy A Reference
       Region 6bxy A 1-1 disorder
       Region 6bxy A 2-53 order
       Region 6bxy A 74-386 order
       Region 6bxy A 399-459 order
       Region 6bxy A 537-538 order
       Region 6bxy A 539-548 disorder
       Region 6bxy A 549-588 order
       Region 6bxy A 589-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 4gq4 A Reference
       Region 4gq4 A 1-1 disorder
       Region 4gq4 A 2-53 order
       Region 4gq4 A 74-386 order
       Region 4gq4 A 399-459 order
       Region 4gq4 A 537-538 order
       Region 4gq4 A 539-548 disorder
       Region 4gq4 A 549-588 order
       Region 4gq4 A 589-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 5db2 A Reference
       Region 5db2 A 1-1 disorder
       Region 5db2 A 2-53 order
       Region 5db2 A 74-386 order
       Region 5db2 A 399-459 order
       Region 5db2 A 537-548 disorder
       Region 5db2 A 549-588 order
       Region 5db2 A 589-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 6o5i A Reference
       Region 6o5i A 1-1 disorder
       Region 6o5i A 2-53 order
       Region 6o5i A 74-386 order
       Region 6o5i A 399-459 order
       Region 6o5i A 537-548 disorder
       Region 6o5i A 549-588 order
       Region 6o5i A 589-593 disorder
Seq 1-53,74-386,399-459,549-593 Hetero tetramer :
 Evidence X-RAY 4og3 A Reference
       Region 4og3 A 1-1 disorder
       Region 4og3 A 2-53 order
       Region 4og3 A 74-386 order
       Region 4og3 A 399-459 order
       Region 4og3 A 549-586 order
       Region 4og3 A 587-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 6by8 A Reference
       Region 6by8 A 1-1 disorder
       Region 6by8 A 2-53 order
       Region 6by8 A 74-386 order
       Region 6by8 A 399-459 order
       Region 6by8 A 537-538 order
       Region 6by8 A 539-548 disorder
       Region 6by8 A 549-588 order
       Region 6by8 A 589-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 5ddb A Reference
       Region 5ddb A 1-2 disorder
       Region 5ddb A 3-53 order
       Region 5ddb A 74-386 order
       Region 5ddb A 399-459 order
       Region 5ddb A 537-548 disorder
       Region 5ddb A 549-586 order
       Region 5ddb A 587-593 disorder
Seq 1-386,399-459,537-593 Hetero trimer :
 Evidence X-RAY 6bxh A Reference
       Region 6bxh A 1-1 disorder
       Region 6bxh A 2-53 order
       Region 6bxh A 54-73 disorder
       Region 6bxh A 74-386 order
       Region 6bxh A 399-459 order
       Region 6bxh A 537-538 order
       Region 6bxh A 539-548 disorder
       Region 6bxh A 549-588 order
       Region 6bxh A 589-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero pentamer : IID00379Complex
 Evidence X-RAY 4gq6 A Reference
       Region 4gq6 A 1-1 disorder
       Region 4gq6 A 2-53 order
       Region 4gq6 A 74-386 order
       Region 4gq6 A 399-459 order
       Region 4gq6 A 537-537 order
       Region 4gq6 A 538-548 disorder
       Region 4gq6 A 549-588 order
       Region 4gq6 A 589-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 5ddc A Reference
       Region 5ddc A 1-2 disorder
       Region 5ddc A 3-53 order
       Region 5ddc A 74-386 order
       Region 5ddc A 399-459 order
       Region 5ddc A 537-548 disorder
       Region 5ddc A 549-588 order
       Region 5ddc A 589-593 disorder
Seq 1-53,74-386,399-459,537-593 Hetero tetramer :
 Evidence X-RAY 5ddd A Reference
       Region 5ddd A 1-1 disorder
       Region 5ddd A 2-53 order
       Region 5ddd A 74-386 order
       Region 5ddd A 399-459 order
       Region 5ddd A 537-548 disorder
       Region 5ddd A 549-588 order
       Region 5ddd A 589-593 disorder
Seq 1-459,520-610 Hetero octamer :
 Evidence X-RAY 8ig0 D Reference
       Region 8ig0 D 1-1 disorder
       Region 8ig0 D 2-385 order
       Region 8ig0 D 386-401 disorder
       Region 8ig0 D 402-459 order
       Region 8ig0 D 520-528 order
       Region 8ig0 D 529-547 disorder
       Region 8ig0 D 548-581 order
       Region 8ig0 D 582-610 disorder
 Evidence X-RAY 8ig0 C Reference
       Region 8ig0 C 1-1 disorder
       Region 8ig0 C 2-382 order
       Region 8ig0 C 383-401 disorder
       Region 8ig0 C 402-459 order
       Region 8ig0 C 520-528 order
       Region 8ig0 C 529-548 disorder
       Region 8ig0 C 549-583 order
       Region 8ig0 C 584-610 disorder
 Evidence X-RAY 8ig0 B Reference
       Region 8ig0 B 1-1 disorder
       Region 8ig0 B 2-385 order
       Region 8ig0 B 386-401 disorder
       Region 8ig0 B 402-459 order
       Region 8ig0 B 520-528 order
       Region 8ig0 B 529-545 disorder
       Region 8ig0 B 546-584 order
       Region 8ig0 B 585-610 disorder
 Evidence X-RAY 8ig0 A Reference
       Region 8ig0 A 1-1 disorder
       Region 8ig0 A 2-385 order
       Region 8ig0 A 386-401 disorder
       Region 8ig0 A 402-459 order
       Region 8ig0 A 520-528 order
       Region 8ig0 A 529-547 disorder
       Region 8ig0 A 548-582 order
       Region 8ig0 A 583-610 disorder
Seq 2-457,552-583 Hetero tetramer :
 Evidence X-RAY 6pkc B Reference
       Region 6pkc B 2-52 order
       Region 6pkc B 53-65 disorder
       Region 6pkc B 66-387 order
       Region 6pkc B 388-400 disorder
       Region 6pkc B 401-457 order
       Region 6pkc B 552-582 order
       Region 6pkc B 583-583 disorder
 Evidence X-RAY 6pkc A Reference
       Region 6pkc A 2-52 order
       Region 6pkc A 53-65 disorder
       Region 6pkc A 66-387 order
       Region 6pkc A 388-400 disorder
       Region 6pkc A 401-457 order
       Region 6pkc A 552-583 order
Seq 2-459,520-610 Hetero dimer :
 Evidence X-RAY 6wnh A Reference
       Region 6wnh A 2-70 order
       Region 6wnh A 71-73 disorder
       Region 6wnh A 74-385 order
       Region 6wnh A 386-401 disorder
       Region 6wnh A 402-459 order
       Region 6wnh A 520-527 order
       Region 6wnh A 528-547 disorder
       Region 6wnh A 548-581 order
       Region 6wnh A 582-610 disorder
Seq 2-459,520-610 Hetero trimer : IID00379Complex
 Evidence X-RAY 3u85 A Reference
       Region 3u85 A 2-385 order
       Region 3u85 A 386-401 disorder
       Region 3u85 A 402-459 order
       Region 3u85 A 520-527 order
       Region 3u85 A 528-547 disorder
       Region 3u85 A 548-581 order
       Region 3u85 A 582-610 disorder
Seq 2-458,520-610 Hetero tetramer :
 Evidence X-RAY 4i80 A Reference
       Region 4i80 A 2-385 order
       Region 4i80 A 386-401 disorder
       Region 4i80 A 402-458 order
       Region 4i80 A 520-527 order
       Region 4i80 A 528-547 disorder
       Region 4i80 A 548-581 order
       Region 4i80 A 582-610 disorder
Seq 2-459,520-610 Hetero trimer : IID00542Complex
 Evidence X-RAY 3u86 A Reference
       Region 3u86 A 2-385 order
       Region 3u86 A 386-401 disorder
       Region 3u86 A 402-459 order
       Region 3u86 A 520-527 order
       Region 3u86 A 528-547 disorder
       Region 3u86 A 548-581 order
       Region 3u86 A 582-610 disorder
Seq 2-459,520-610 Hetero tetramer : IID00379Complex,IID00408Complex
 Evidence X-RAY 3u88 A Reference
       Region 3u88 A 2-70 order
       Region 3u88 A 71-72 disorder
       Region 3u88 A 73-385 order
       Region 3u88 A 386-401 disorder
       Region 3u88 A 402-459 order
       Region 3u88 A 520-546 disorder
       Region 3u88 A 547-583 order
       Region 3u88 A 584-610 disorder
Seq 2-459,520-610 Hetero dimer :
 Evidence X-RAY 6e1a A Reference
       Region 6e1a A 2-70 order
       Region 6e1a A 71-73 disorder
       Region 6e1a A 74-385 order
       Region 6e1a A 386-401 disorder
       Region 6e1a A 402-459 order
       Region 6e1a A 520-527 order
       Region 6e1a A 528-547 disorder
       Region 6e1a A 548-581 order
       Region 6e1a A 582-610 disorder
Seq 2-459,520-610 Hetero dimer :
 Evidence X-RAY 7m4t A Reference
       Region 7m4t A 2-70 order
       Region 7m4t A 71-73 disorder
       Region 7m4t A 74-385 order
       Region 7m4t A 386-401 disorder
       Region 7m4t A 402-459 order
       Region 7m4t A 520-527 order
       Region 7m4t A 528-547 disorder
       Region 7m4t A 548-581 order
       Region 7m4t A 582-610 disorder
Seq 2-459,520-610 Hetero dimer :
 Evidence X-RAY 3u84 A Reference
       Region 3u84 A 2-386 order
       Region 3u84 A 387-401 disorder
       Region 3u84 A 402-459 order
       Region 3u84 A 520-528 order
       Region 3u84 A 529-533 disorder
       Region 3u84 A 534-539 order
       Region 3u84 A 540-547 disorder
       Region 3u84 A 548-581 order
       Region 3u84 A 582-595 disorder
       Region 3u84 A 596-608 order
       Region 3u84 A 609-610 disorder
Seq 2-459,520-610 Hetero tetramer : IID00379Complex,IID00408Complex
 Evidence X-RAY 3u88 B Reference
       Region 3u88 B 2-386 order
       Region 3u88 B 387-399 disorder
       Region 3u88 B 400-459 order
       Region 3u88 B 520-520 order
       Region 3u88 B 521-543 disorder
       Region 3u88 B 544-582 order
       Region 3u88 B 583-610 disorder
Seq 2-459,520-610 Hetero dimer :
 Evidence X-RAY 6b41 A Reference
       Region 6b41 A 2-70 order
       Region 6b41 A 71-73 disorder
       Region 6b41 A 74-385 order
       Region 6b41 A 386-401 disorder
       Region 6b41 A 402-459 order
       Region 6b41 A 520-527 order
       Region 6b41 A 528-547 disorder
       Region 6b41 A 548-581 order
       Region 6b41 A 582-610 disorder
Seq 2-459,520-610 Hetero dimer :
 Evidence X-RAY 3u84 B Reference
       Region 3u84 B 2-70 order
       Region 3u84 B 71-74 disorder
       Region 3u84 B 75-199 order
       Region 3u84 B 200-205 disorder
       Region 3u84 B 206-385 order
       Region 3u84 B 386-401 disorder
       Region 3u84 B 402-459 order
       Region 3u84 B 520-522 disorder
       Region 3u84 B 523-528 order
       Region 3u84 B 529-547 disorder
       Region 3u84 B 548-581 order
       Region 3u84 B 582-610 disorder
Seqphosphorylation
    594-594 Phosphothreonine
    543-543 Phosphoserine
    487-487 Phosphoserine
 
Prediction
NeProc
Disorder 58-72,379-401,462-547,554-564,574-610
Order 1-53,73-378,402-461,548-553,565-573
ProS 67-72,393-396,472-486,554-564,574-610
AlphaFold
Disorder 1-1,150-154,392-405,465-551,587-615
Order 2-149,155-391,406-464,552-586
SEG 254-270 ,391-402 ,460-499 ,535-549 ,582-593
Function
Function in SwissProt
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.