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IID00410
 UniprotP04271
ProteinProtein S100-B
GeneS100B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
92
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-92 Homo octamer :
 Evidence X-RAY 2h61 H Reference
       Region 2h61 H 1-90 order
       Region 2h61 H 91-92 disorder
 Evidence X-RAY 2h61 G Reference
       Region 2h61 G 1-91 order
       Region 2h61 G 92-92 disorder
 Evidence X-RAY 2h61 F Reference
       Region 2h61 F 1-91 order
       Region 2h61 F 92-92 disorder
 Evidence X-RAY 2h61 E Reference
       Region 2h61 E 1-91 order
       Region 2h61 E 92-92 disorder
 Evidence X-RAY 2h61 D Reference
       Region 2h61 D 1-91 order
       Region 2h61 D 92-92 disorder
 Evidence X-RAY 2h61 C Reference
       Region 2h61 C 1-91 order
       Region 2h61 C 92-92 disorder
 Evidence X-RAY 2h61 B Reference
       Region 2h61 B 1-92 order
 Evidence X-RAY 2h61 A Reference
       Region 2h61 A 1-91 order
       Region 2h61 A 92-92 disorder
Seq 1-92 Homo dimer :
 Evidence X-RAY 3czt X Reference
       Region 3czt X 1-91 order
       Region 3czt X 92-92 disorder
 Evidence X-RAY 3hcm A Reference
       Region 3hcm A 1-90 order
       Region 3hcm A 91-92 disorder
 Evidence X-RAY 3hcm B Reference
       Region 3hcm B 1-91 order
       Region 3hcm B 92-92 disorder
 Evidence X-RAY 4xyn C Reference
       Region 4xyn C 1-91 order
       Region 4xyn C 92-92 disorder
 Evidence X-RAY 4xyn D Reference
       Region 4xyn D 1-88 order
       Region 4xyn D 89-92 disorder
 Evidence X-RAY 3d0y A Reference
       Region 3d0y A 1-90 order
       Region 3d0y A 91-92 disorder
 Evidence X-RAY 3d0y B Reference
       Region 3d0y B 1-90 order
       Region 3d0y B 91-92 disorder
 Evidence X-RAY 3d10 A Reference
       Region 3d10 A 1-92 order
 Evidence X-RAY 3d10 B Reference
       Region 3d10 B 1-91 order
       Region 3d10 B 92-92 disorder
 Evidence NMR 2pru A Reference
       Region 2pru A 2-22 order
       Region 2pru A 21-25 high_rmsd
       Region 2pru A 23-25 disorder
       Region 2pru A 26-92 order
       Region 2pru A 86-92 high_rmsd
 Evidence NMR 2pru B Reference
       Region 2pru B 2-22 order
       Region 2pru B 21-25 high_rmsd
       Region 2pru B 23-25 disorder
       Region 2pru B 26-92 order
       Region 2pru B 46-46 high_rmsd
       Region 2pru B 86-87 high_rmsd
 Evidence NMR 1uwo A Reference
       Region 1uwo A 2-92 order
 Evidence NMR 1uwo B Reference
       Region 1uwo B 2-92 order
Seq 1-92 Hetero trimer : IID00726Complex
 Evidence X-RAY 5csf A Reference
       Region 5csf A 1-89 order
       Region 5csf A 90-92 disorder
 Evidence X-RAY 5csf B Reference
       Region 5csf B 1-89 order
       Region 5csf B 90-92 disorder
 Evidence X-RAY 5csi A Reference
       Region 5csi A 1-90 order
       Region 5csi A 91-92 disorder
 Evidence X-RAY 5csi B Reference
       Region 5csi B 1-89 order
       Region 5csi B 90-92 disorder
Seq 1-92 Hetero trimer : IID00726Complex
 Evidence X-RAY 5csn B Reference
       Region 5csn B 1-89 order
       Region 5csn B 90-92 disorder
 Evidence X-RAY 5csn A Reference
       Region 5csn A 1-91 order
       Region 5csn A 92-92 disorder
Seq 1-92 Hetero trimer : Q15109
 Evidence X-RAY 4xyn B Reference
       Region 4xyn B 1-91 order
       Region 4xyn B 92-92 disorder
 Evidence X-RAY 4xyn A Reference
       Region 4xyn A 1-90 order
       Region 4xyn A 91-92 disorder
Seq 1-92 Hetero trimer : Q15109
 Evidence X-RAY 5d7f B Reference
       Region 5d7f B 1-91 order
       Region 5d7f B 92-92 disorder
 Evidence X-RAY 5d7f A Reference
       Region 5d7f A 1-91 order
       Region 5d7f A 92-92 disorder
Seq 1-92 Hetero trimer : IID00726Complex
 Evidence X-RAY 5csj B Reference
       Region 5csj B 1-89 order
       Region 5csj B 90-92 disorder
 Evidence X-RAY 5csj A Reference
       Region 5csj A 1-90 order
       Region 5csj A 91-92 disorder
Seq 2-92 Hetero tetramer : IID00122Complex
 Evidence NMR 1mq1 B Reference
       Region 1mq1 B 2-92 order
       Region 1mq1 B 22-22 high_rmsd
       Region 1mq1 B 44-47 high_rmsd
       Region 1mq1 B 91-92 high_rmsd
 Evidence NMR 1mq1 A Reference
       Region 1mq1 A 2-92 order
       Region 1mq1 A 22-22 high_rmsd
       Region 1mq1 A 44-47 high_rmsd
       Region 1mq1 A 91-92 high_rmsd
Seq 2-92 Hetero tetramer : IID00438Complex
 Evidence NMR 2m49 D Reference
       Region 2m49 D 2-92 order
 Evidence NMR 2m49 B Reference
       Region 2m49 B 2-92 order
Seqacetylation
    2-2 N-acetylserine; alternate
 
Prediction
NeProc
Order 1-92
AlphaFold
Disorder 91-92
Order 1-90
Pfam Hmmer
PF01023 4-47 6.7e-24
PF00036 53-81 0.00018
SEG 27-42
Function
Function in SwissProt
Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (PubMed:6487634, PubMed:20950652). Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer (PubMed:6487634, PubMed:20950652). Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites (By similarity). Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation (By similarity). Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue (By similarity). Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase (By similarity). Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (PubMed:20351179). May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (PubMed:22399290).
Biological Process
Diagram with PDB data
S100B/S100BCALCIUM FORM OF HUMAN S100B, NMR, 20 STRUCTURES
See also
Diagram with PDB data
TP53/S100BSOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)
RPS6KA1/S100BS100B-RSK1 crystal structure C