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IID00412
 UniprotP31749
ProteinRAC-alpha serine/threonine-protein kinase
GeneAKT1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
480
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-123 Monomer :
 Evidence X-RAY 1h10 A Reference
       Region 1h10 A 1-116 order
       Region 1h10 A 117-123 disorder
 Evidence X-RAY 1unp A Reference
       Region 1unp A 1-2 disorder
       Region 1unp A 3-121 order
 Evidence X-RAY 1unq A Reference
       Region 1unq A 1-116 order
       Region 1unq A 117-123 disorder
 Evidence X-RAY 1unr A Reference
       Region 1unr A 1-2 disorder
       Region 1unr A 3-42 order
       Region 1unr A 43-47 disorder
       Region 1unr A 48-120 order
       Region 1unr A 121-123 disorder
 Evidence X-RAY 2uvm A Reference
       Region 2uvm A 1-115 order
       Region 2uvm A 116-123 disorder
 Evidence X-RAY 2uzr A Reference
       Region 2uzr A 1-2 disorder
       Region 2uzr A 3-42 order
       Region 2uzr A 43-47 disorder
       Region 2uzr A 48-120 order
       Region 2uzr A 121-123 disorder
 Evidence X-RAY 2uzs A Reference
       Region 2uzs A 1-116 order
       Region 2uzs A 117-123 disorder
Seq 2-480 Monomer :
 Evidence X-RAY 4ejn A Reference
       Region 4ejn A 2-3 disorder
       Region 4ejn A 4-42 order
       Region 4ejn A 43-49 disorder
       Region 4ejn A 50-109 order
       Region 4ejn A 110-143 disorder
       Region 4ejn A 144-187 order
       Region 4ejn A 188-200 disorder
       Region 4ejn A 201-301 order
       Region 4ejn A 302-306 disorder
       Region 4ejn A 307-438 order
       Region 4ejn A 439-446 disorder
 Evidence X-RAY 4ekl A Reference
       Region 4ekl A 144-451 order
       Region 4ekl A 452-456 disorder
       Region 4ekl A 457-478 order
       Region 4ekl A 479-480 disorder
 Evidence X-RAY 4gv1 A Reference
       Region 4gv1 A 144-451 order
       Region 4gv1 A 452-456 disorder
       Region 4gv1 A 457-477 order
       Region 4gv1 A 478-480 disorder
 Evidence X-RAY 5kcv A Reference
       Region 5kcv A 2-5 disorder
       Region 5kcv A 6-19 order
       Region 5kcv A 20-20 disorder
       Region 5kcv A 21-42 order
       Region 5kcv A 43-49 disorder
       Region 5kcv A 50-104 order
       Region 5kcv A 105-143 disorder
       Region 5kcv A 144-183 order
       Region 5kcv A 184-200 disorder
       Region 5kcv A 201-296 order
       Region 5kcv A 297-312 disorder
       Region 5kcv A 313-438 order
       Region 5kcv A 439-446 disorder
 Evidence X-RAY 3o96 A Reference
       Region 3o96 A 2-45 order
       Region 3o96 A 46-48 disorder
       Region 3o96 A 49-88 order
       Region 3o96 A 89-91 disorder
       Region 3o96 A 92-113 order
       Region 3o96 A 114-144 disorder
       Region 3o96 A 145-188 order
       Region 3o96 A 189-198 disorder
       Region 3o96 A 199-298 order
       Region 3o96 A 299-312 disorder
       Region 3o96 A 313-429 order
       Region 3o96 A 430-443 disorder
 Evidence X-RAY 3qkm A Reference
       Region 3qkm A 144-451 order
       Region 3qkm A 452-456 disorder
       Region 3qkm A 457-478 order
       Region 3qkm A 479-480 disorder
Seq 144-480 Hetero dimer :
 Evidence X-RAY 3mvh A Reference
       Region 3mvh A 144-144 disorder
       Region 3mvh A 145-445 order
       Region 3mvh A 446-465 disorder
       Region 3mvh A 466-476 order
       Region 3mvh A 477-480 disorder
Seq 144-480 Hetero dimer :
 Evidence X-RAY 3qkl A Reference
       Region 3qkl A 144-448 order
       Region 3qkl A 449-465 disorder
       Region 3qkl A 466-478 order
       Region 3qkl A 479-480 disorder
Seq 144-480 Hetero dimer :
 Evidence X-RAY 3ocb B Reference
       Region 3ocb B 144-450 order
       Region 3ocb B 451-465 disorder
       Region 3ocb B 466-478 order
       Region 3ocb B 479-480 disorder
Seq 144-480 Hetero dimer :
 Evidence X-RAY 3ocb A Reference
       Region 3ocb A 144-446 order
       Region 3ocb A 447-465 disorder
       Region 3ocb A 466-478 order
       Region 3ocb A 479-480 disorder
Seq 144-480 Hetero dimer : IID00052Complex
 Evidence X-RAY 3cqu A Reference
       Region 3cqu A 144-446 order
       Region 3cqu A 447-462 disorder
       Region 3cqu A 463-478 order
       Region 3cqu A 479-480 disorder
 Evidence X-RAY 3cqw A Reference
       Region 3cqw A 144-447 order
       Region 3cqw A 448-463 disorder
       Region 3cqw A 464-478 order
       Region 3cqw A 479-480 disorder
 Evidence X-RAY 4ekk A Reference
       Region 4ekk A 144-447 order
       Region 4ekk A 448-462 disorder
       Region 4ekk A 463-477 order
       Region 4ekk A 478-480 disorder
 Evidence X-RAY 4ekk B Reference
       Region 4ekk B 144-447 order
       Region 4ekk B 448-462 disorder
       Region 4ekk B 463-477 order
       Region 4ekk B 478-480 disorder
 Evidence X-RAY 3mv5 A Reference
       Region 3mv5 A 144-447 order
       Region 3mv5 A 448-465 disorder
       Region 3mv5 A 466-477 order
       Region 3mv5 A 478-480 disorder
 Evidence X-RAY 3ow4 A Reference
       Region 3ow4 A 144-448 order
       Region 3ow4 A 449-465 disorder
       Region 3ow4 A 466-478 order
       Region 3ow4 A 479-480 disorder
 Evidence X-RAY 3ow4 B Reference
       Region 3ow4 B 144-448 order
       Region 3ow4 B 449-465 disorder
       Region 3ow4 B 466-478 order
       Region 3ow4 B 479-480 disorder
 Evidence X-RAY 3qkk A Reference
       Region 3qkk A 144-449 order
       Region 3qkk A 450-457 disorder
       Region 3qkk A 458-478 order
       Region 3qkk A 479-480 disorder
SeqProS verified 189-198,299-312 This region is activation segment. Hetero dimer :
       Region 3ocb B 144-450 order
       Region 3o96 A 189-198 disorder
       Region 3o96 A 299-312 disorder
SeqProS verified 189-198,299-312 This region is activation segment. Hetero dimer :
       Region 3qkl A 144-448 order
       Region 3o96 A 189-198 disorder
       Region 3o96 A 299-312 disorder
SeqProS verified 189-198,299-312 This region is activation segment. :
       Region 3qkm A 144-451 order
       Region 3o96 A 189-198 disorder
       Region 3o96 A 299-312 disorder
SeqProS verified 189-198,299-312 This region is activation segment. Hetero dimer : IID00052Complex
       Region 3ow4 A 144-448 order
       Region 3ow4 B 144-448 order
       Region 3cqu A 144-446 order
       Region 3cqw A 144-447 order
       Region 3qkk A 144-449 order
       Region 3mv5 A 144-447 order
       Region 3o96 A 189-198 disorder
       Region 3o96 A 299-312 disorder
SeqProS verified 189-198,299-312 This region is activation segment. Hetero dimer :
       Region 3ocb A 144-446 order
       Region 3o96 A 189-198 disorder
       Region 3o96 A 299-312 disorder
SeqProS verified 189-198,299-312 This region is activation segment. Hetero dimer :
       Region 3mvh A 145-445 order
       Region 3o96 A 189-198 disorder
       Region 3o96 A 299-312 disorder
Seqphosphorylation
    474-474 Phosphotyrosine
    473-473 Phosphoserine; by IKKE
    450-450 Phosphothreonine
    448-448 Phosphothreonine
    308-308 Phosphothreonine; by IKKE
    176-176 Phosphotyrosine; by TNK2
    129-129 Phosphoserine; alternate
    126-126 Phosphoserine; alternate
    124-124 Phosphoserine
Seqacetylation
    20-20 N6-acetyllysine
    14-14 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-3,110-145,455-465,475-480
Order 4-109,146-454,466-474
ProS 475-480
AlphaFold
Disorder 1-3,17-19,44-52,78-84,117-143,302-304,307-308,323-324,447-468,470-471,477-480
Order 4-16,20-43,53-77,85-116,144-301,305-306,309-322,325-446,469-469,472-476
Pfam Hmmer
PF00169 6-108 4.1e-22
PF00069 150-408 8.7e-114
PF00433 428-478 2.6e-11
Function
Function in SwissProt
AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
Biological Process
See also
Diagram with PDB data
TERT/KPNA1The crystal structure of human Importin alpha 5 with TERT NLS peptide
FOXO3/YWHAECrystal Structure of 14-3-3 epsilon with FOXO3a peptide
CREB1/CRBBP/KMT2AAllosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core
CDKN1A/PCNAHuman PCNA
MTOR/MLST8/AKT1S1Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex
GSK3B/AKT1Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor
FOXO1/SFN14-3-3 sigma in complex with FOXO1 pT24 peptide
Diagram without PDB data
CDKN1BActivation of Akt results in phosphorylation p27, which are then transported to the cytoplasm with 14-3-3.
FOXO4Stress signals in FOXO regulation