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IID00417  Kinetochore scaffold 1 (Homo sapiens) Q8NG31
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
2342
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 176-226 Hetero dimer : IID00406Complex
 Evidence X-RAY 4a1g E Reference
       Region 4a1g E 176-201 disorder
       Region 4a1g E 202-213 order
       Region 4a1g E 214-226 disorder
 Evidence X-RAY 4a1g F Reference
       Region 4a1g F 176-200 disorder
       Region 4a1g F 201-215 order
       Region 4a1g F 216-226 disorder
 Evidence X-RAY 4a1g G Reference
       Region 4a1g G 176-200 disorder
       Region 4a1g G 201-215 order
       Region 4a1g G 216-226 disorder
 Evidence X-RAY 4a1g H Reference
       Region 4a1g H 176-200 disorder
       Region 4a1g H 201-216 order
       Region 4a1g H 217-226 disorder
Seq 234-252 Hetero dimer : IID00407Complex
 Evidence X-RAY 3si5 X Reference
       Region 3si5 X 234-251 order
       Region 3si5 X 252-252 disorder
 Evidence X-RAY 3si5 Y Reference
       Region 3si5 Y 234-237 disorder
       Region 3si5 Y 238-250 order
       Region 3si5 Y 251-252 disorder
Seqdisorder 243-252
 Evidence CD Reference
       Region 243-252 disorder
Seq 2117-2337 Hetero dimer : Q96IY1
 Evidence X-RAY 4nf9 A Reference
       Region 4nf9 A 2117-2121 disorder
       Region 4nf9 A 2122-2337 order
 Evidence X-RAY 4nf9 B Reference
       Region 4nf9 B 2117-2130 disorder
       Region 4nf9 B 2131-2337 order
Seq 2131-2337 Monomer :
 Evidence X-RAY 4nfa A Reference
       Region 4nfa A 2131-2213 order
       Region 4nfa A 2214-2216 disorder
       Region 4nfa A 2217-2337 order
SeqProS possible 201-216 This region is described to be disordered in the free state (PubMed=22331848). Hetero dimer : IID00406Complex
       Region 4a1g F 201-215 order
       Region 4a1g G 201-215 order
       Region 4a1g H 201-216 order
SeqProS verified 234-251 Hetero dimer : IID00407Complex
       Region 3si5 X 234-251 order
       Region 3si5 Y 238-250 order
       Region 243-252 disorder
Seqphosphorylation
    32-32 Phosphoserine
    60-60 Phosphoserine
    539-539 Phosphothreonine
    578-578 Phosphoserine
    584-584 Phosphoserine
    586-586 Phosphothreonine
    767-767 Phosphoserine
    956-956 Phosphoserine
    1039-1039 Phosphoserine
    1076-1076 Phosphoserine
    1088-1088 Phosphoserine
    1448-1448 Phosphoserine
    1675-1675 Phosphoserine
    1773-1773 Phosphoserine
    1831-1831 Phosphoserine
    1845-1845 Phosphoserine
    1860-1860 Phosphoserine
 
Prediction
DICHOT
Disorder 1-106,225-335,390-447,482-583,621-773,804-1179,1300-1395,1472-1502,1582-1597,1636-1659,1738-1787,1835-1860,2064-2072,2338-2342
Known Domain 2122-2337
Cryptic Domain 107-224,336-389,448-481,584-620,774-803,1180-1299,1396-1471,1503-1581,1598-1635,1660-1737,1788-1834,1861-2063,2073-2121
Pfam RPS-Blast
     PF08317 1890-2160 7e-15 Spc7 kinetochore protein
     PF18210 2239-2336 1e-38 Knl1 RWD C-terminal domai...
Pfam Hmmer
    PF18210 2239-2336 6.1e-47 Knl1 RWD C-terminal doma...