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IID00419
 UniprotQ96E14
ProteinRecQ-mediated genome instability protein 2
GeneRMI2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
147
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-147 Hetero trimer : IID00421Complex,IID00484Complex
 Evidence X-RAY 4day B Reference
       Region 4day B 1-12 disorder
       Region 4day B 13-33 order
       Region 4day B 34-55 disorder
       Region 4day B 56-147 order
Seq 1-147 Hetero dimer : IID00421Complex
 Evidence X-RAY 3nbh B Reference
       Region 3nbh B 6-16 disorder
       Region 3nbh B 17-147 order
 Evidence X-RAY 3mxn B Reference
       Region 3mxn B 1-16 disorder
       Region 3mxn B 17-147 order
Seqphosphorylation
    7-7 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-18,39-44
Order 19-38,45-147
ProS 39-44
AlphaFold
Disorder 1-17
Order 18-147
Function
Function in SwissProt
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.
Biological Process
See also
Diagram with PDB data
FANCM/RMI1/RMI2Crystal structure of the RMI core complex with MM2 peptide from FANCM