Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG
455
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Seq 80-455 Hetero tetramer : IID00031 Complex ,
IID00082 Complex
Region 5uan B 80-86 disorder
Region 5uan B 87-159 order
Region 5uan B 160-180 disorder
Region 5uan B 181-415 order
Region 5uan B 416-455 disorder
Region 1hra A 82-160 order
Region 1xap A 176-181 disorder
Region 1xap A 182-368 order
Region 1xap A 369-371 disorder
Region 1xap A 372-416 order
Region 1xap A 417-421 disorder
Seq 176-421 Hetero tetramer : IID00083 Complex
Region 4jyg A 176-176 disorder
Region 4jyg A 177-415 order
Region 4jyg A 416-421 disorder
Region 4jyg B 176-415 order
Region 4jyg B 416-421 disorder
Region 4jyh A 176-176 disorder
Region 4jyh A 177-415 order
Region 4jyh A 416-421 disorder
Region 4jyh B 176-176 disorder
Region 4jyh B 177-415 order
Region 4jyh B 416-421 disorder
Region 4jyi A 176-176 disorder
Region 4jyi A 177-415 order
Region 4jyi A 416-421 disorder
Region 4jyi B 176-176 disorder
Region 4jyi B 177-415 order
Region 4jyi B 416-421 disorder
Seq 176-421 Hetero dimer : IID00083 Complex
Region 4dm6 A 176-415 order
Region 4dm6 A 416-421 disorder
Region 4dm6 B 176-177 disorder
Region 4dm6 B 178-416 order
Region 4dm6 B 417-421 disorder
Region 4dm8 A 176-368 order
Region 4dm8 A 369-370 disorder
Region 4dm8 A 371-415 order
Region 4dm8 A 416-421 disorder
Region 4dm8 B 176-177 disorder
Region 4dm8 B 178-416 order
Region 4dm8 B 417-421 disorder
Prediction
Disorder 1-84,160-187,212-221,419-455
Order 85-159,188-211,222-418
ProS 24-28,160-163,184-187,452-455
Disorder 1-74,161-179,416-455
SEG 34-52
,67-82
,435-452
Function
Function in SwissProt
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
Biological Process
See also
Diagram with PDB data
NCOA1/RARA Crystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment