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IID00439
UniprotP10826
ProteinRetinoic acid receptor beta
GeneRARB
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
455
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 80-455 Hetero tetramer : IID00031Complex,IID00082Complex
 Evidence X-RAY 5uan B Reference
       Region 5uan B 80-86 disorder
       Region 5uan B 87-159 order
       Region 5uan B 160-180 disorder
       Region 5uan B 181-415 order
       Region 5uan B 416-455 disorder
Seq 82-160 Monomer :
 Evidence NMR 1hra A Reference
       Region 1hra A 82-160 order
Seq 176-421 Monomer :
 Evidence X-RAY 1xap A Reference
       Region 1xap A 176-181 disorder
       Region 1xap A 182-368 order
       Region 1xap A 369-371 disorder
       Region 1xap A 372-416 order
       Region 1xap A 417-421 disorder
Seq 176-421 Hetero tetramer : IID00083Complex
 Evidence X-RAY 4jyg A Reference
       Region 4jyg A 176-176 disorder
       Region 4jyg A 177-415 order
       Region 4jyg A 416-421 disorder
 Evidence X-RAY 4jyg B Reference
       Region 4jyg B 176-415 order
       Region 4jyg B 416-421 disorder
 Evidence X-RAY 4jyh A Reference
       Region 4jyh A 176-176 disorder
       Region 4jyh A 177-415 order
       Region 4jyh A 416-421 disorder
 Evidence X-RAY 4jyh B Reference
       Region 4jyh B 176-176 disorder
       Region 4jyh B 177-415 order
       Region 4jyh B 416-421 disorder
 Evidence X-RAY 4jyi A Reference
       Region 4jyi A 176-176 disorder
       Region 4jyi A 177-415 order
       Region 4jyi A 416-421 disorder
 Evidence X-RAY 4jyi B Reference
       Region 4jyi B 176-176 disorder
       Region 4jyi B 177-415 order
       Region 4jyi B 416-421 disorder
Seq 176-421 Hetero dimer : IID00083Complex
 Evidence X-RAY 4dm6 A Reference
       Region 4dm6 A 176-415 order
       Region 4dm6 A 416-421 disorder
 Evidence X-RAY 4dm6 B Reference
       Region 4dm6 B 176-177 disorder
       Region 4dm6 B 178-416 order
       Region 4dm6 B 417-421 disorder
 Evidence X-RAY 4dm8 A Reference
       Region 4dm8 A 176-368 order
       Region 4dm8 A 369-370 disorder
       Region 4dm8 A 371-415 order
       Region 4dm8 A 416-421 disorder
 Evidence X-RAY 4dm8 B Reference
       Region 4dm8 B 176-177 disorder
       Region 4dm8 B 178-416 order
       Region 4dm8 B 417-421 disorder
Seqphosphorylation
    77-77 Phosphoserine
 
Prediction
NeProc
Disorder 1-84,160-187,212-221,419-455
Order 85-159,188-211,222-418
ProS 24-28,160-163,184-187,452-455
AlphaFold
Disorder 1-74,161-179,416-455
Order 75-160,180-415
Pfam Hmmer
PF00105 86-161 4.6e-55
PF00104 233-413 6e-45
SEG 34-52 ,67-82 ,435-452
Function
Function in SwissProt
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment