IDEAL Node

IDEAL

IID00443 Interferon-induced, double-stranded RNA-activated protein kinase (Homo sapiens) P19525

:order :disorder :conflict :PDB cluster :ProS :SCOP Domain :Pfam Domain

Network xml

Experiment

551

fasta

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 1-170 Monomer :

Evidence NMR 1qu6 A Reference

Region 1qu6 A 1-170 order

Region 1qu6 A 5-6 high_rmsd

Region 1qu6 A 33-38 high_rmsd

Region 1qu6 A 79-100 high_rmsd

Region 1qu6 A 107-113 high_rmsd

Region 1qu6 A 123-130 high_rmsd

Region 1qu6 A 167-170 high_rmsd

Seq 254-551 Monomer :

Evidence X-RAY 3uiu B Reference

Region 3uiu B 254-336 order

Region 3uiu B 337-354 disorder

Region 3uiu B 355-439 order

Region 3uiu B 440-450 disorder

Region 3uiu B 451-460 order

Region 3uiu B 461-464 disorder

Region 3uiu B 465-541 order

Region 3uiu B 542-551 disorder

Evidence X-RAY 3uiu A Reference

Region 3uiu A 254-336 order

Region 3uiu A 337-354 disorder

Region 3uiu A 355-439 order

Region 3uiu A 440-450 disorder

Region 3uiu A 451-460 order

Region 3uiu A 461-464 disorder

Region 3uiu A 465-541 order

Region 3uiu A 542-551 disorder

Seq 258-337,351-550 Hetero tetramer : IID50184Complex

Evidence X-RAY 2a1a B Reference

Region 2a1a B 258-337 order

Region 2a1a B 351-354 disorder

Region 2a1a B 355-541 order

Region 2a1a B 542-550 disorder

Seq 258-337,351-550 Hetero trimer : IID50184Complex

Evidence X-RAY 2a19 C Reference

Region 2a19 C 258-337 order

Region 2a19 C 351-357 disorder

Region 2a19 C 358-374 order

Region 2a19 C 375-389 disorder

Region 2a19 C 390-436 order

Region 2a19 C 437-465 disorder

Region 2a19 C 466-482 order

Region 2a19 C 483-500 disorder

Region 2a19 C 501-541 order

Region 2a19 C 542-550 disorder

Evidence X-RAY 2a19 B Reference

Region 2a19 B 258-333 order

Region 2a19 B 334-337 disorder

Region 2a19 B 351-355 disorder

Region 2a19 B 356-541 order

Region 2a19 B 542-550 disorder

Seqphosphorylation

542-542 Phosphoserine

456-456 Phosphoserine

451-451 Phosphothreonine; by autocatalysis

446-446 Phosphothreonine; by autocatalysis

293-293 Phosphotyrosine; by autocatalysis

258-258 Phosphothreonine; by autocatalysis

255-255 Phosphothreonine; by autocatalysis

242-242 Phosphoserine; by autocatalysis

162-162 Phosphotyrosine; by autocatalysis

101-101 Phosphotyrosine; by autocatalysis

90-90 Phosphothreonine; by autocatalysis

89-89 Phosphothreonine; by autocatalysis

88-88 Phosphothreonine; by autocatalysis

83-83 Phosphoserine

88-88 Phosphothreonine; by autocatalysis

89-89 Phosphothreonine; by autocatalysis

90-90 Phosphothreonine; by autocatalysis

101-101 Phosphotyrosine; by autocatalysis

162-162 Phosphotyrosine; by autocatalysis

242-242 Phosphoserine; by autocatalysis

255-255 Phosphothreonine; by autocatalysis

258-258 Phosphothreonine; by autocatalysis

293-293 Phosphotyrosine; by autocatalysis

446-446 Phosphothreonine; by autocatalysis

451-451 Phosphothreonine; by autocatalysis

456-456 Phosphoserine

542-542 Phosphoserine

Seqacetylation

2-2 N-acetylalanine

Prediction

DICHOT

Disorder 171-256,542-551

Known Domain 1-170,257-541

SCOPe RPS-Blast

1x49A1 1-83 8e-25

1x48A1 101-173 1e-19

2a19B1 258-541 e-115

SCOP Hmmer

1qu6A1 11-79 5.8e-22

1qu6A2 88-167 8.9e-19

1kwpA_ 259-536 2.2e-67

Pfam RPS-Blast

PF00035 13-75 8e-11 Double-stranded RNA binding m...

PF00035 102-164 1e-05 Double-stranded RNA binding...

PF06293 363-434 4e-06 Lipopolysaccharide kinase (...

PF14531 411-484 4e-04 Kinase-like

Pfam Hmmer

PF00035 13-75 7.8e-18 Double-stranded RNA binding ...

PF00035 101-164 1.4e-15 Double-stranded RNA bindin...

PF00069 267-534 7.2e-58 Protein kinase domain