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IID00454
 UniprotP51858
ProteinHepatoma-derived growth factor
GeneHDGF
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
240
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-100 Monomer :
 Evidence NMR 1ri0 A Reference
       Region 1ri0 A 1-100 order
       Region 1ri0 A 1-5 high_rmsd
       Region 1ri0 A 96-100 high_rmsd
Seq 1-100 Homo dimer :
 Evidence NMR 2nlu B Reference
       Region 2nlu B 1-100 order
 Evidence NMR 2nlu A Reference
       Region 2nlu A 1-100 order
Seqdisorder 101-240
 Evidence NMR Reference
       Region 101-240 disorder
Seqphosphorylation
    132-132 Phosphoserine
    133-133 Phosphoserine
    200-200 Phosphothreonine
    165-165 Phosphoserine
    184-184 Phosphothreonine
    199-199 Phosphoserine
    239-239 Phosphoserine
    206-206 Phosphoserine
    202-202 Phosphoserine
Seqacetylation
    44-44 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-5,87-240
Order 6-86
ProS 87-101,124-129,236-240
AlphaFold
Disorder 1-7,39-39,98-140,142-143,145-230,232-235,238-238,240-240
Order 8-38,40-97,141-141,144-144,231-231,236-237,239-239
Pfam Hmmer
PF00855 9-81 2.5e-35
SEG 110-120 ,169-183 ,213-231
Function
Function in SwissProt
Isoform 1
Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618).
Isoform 2
Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719).
Isoform 3
Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719).