IDEAL Node

IDEAL

IID00463 Neurogenic locus notch homolog protein 2 (Homo sapiens) Q04721

:order :disorder :conflict :PDB cluster :ProS :SCOP Domain :Pfam Domain

xml

Experiment

2471

fasta

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 414-532 Monomer :

Evidence X-RAY 5mwb A Reference

Region 5mwb A 414-414 disorder

Region 5mwb A 415-532 order

Seq 1423-1594,1617-1677 Monomer :

Evidence X-RAY 2oo4 B Reference

Region 2oo4 B 1423-1424 disorder

Region 2oo4 B 1425-1594 order

Region 2oo4 B 1617-1672 order

Region 2oo4 B 1673-1677 disorder

Evidence X-RAY 2oo4 A Reference

Region 2oo4 A 1423-1424 disorder

Region 2oo4 A 1425-1594 order

Region 2oo4 A 1617-1672 order

Region 2oo4 A 1673-1677 disorder

Seqphosphorylation

2097-2097 Phosphothreonine

2081-2081 Phosphoserine

2078-2078 Phosphoserine

2070-2070 Phosphoserine

1845-1845 Phosphoserine

1842-1842 Phosphoserine

1808-1808 Phosphothreonine

1804-1804 Phosphoserine

1802-1802 Phosphothreonine

1778-1778 Phosphoserine

1716-1716 Phosphothreonine

2081-2081 Phosphoserine

2097-2097 Phosphothreonine

2078-2078 Phosphoserine

1845-1845 Phosphoserine

2070-2070 Phosphoserine

1842-1842 Phosphoserine

1802-1802 Phosphothreonine

1804-1804 Phosphoserine

1808-1808 Phosphothreonine

1778-1778 Phosphoserine

1716-1716 Phosphothreonine

Prediction

DICHOT

Disorder 1-52,413-414,835-853,1101-1119,1673-1677,1701-1871,2064-2471

Known Domain 53-412,415-834,854-1100,1120-1672,1678-1700,1872-2063

SCOPe RPS-Blast

1egfA 66-104 3e-05

1g1tA2 145-183 9e-07

5mwbA1 182-218 2e-08

1g1tA2 225-261 3e-04

1edmB 260-295 2e-07

5mwbA1 298-338 7e-07

5mwbA1 415-456 2e-11

1edmB 456-493 6e-10

1edmB 494-531 1e-10

1edmB 531-568 4e-10

1autL1 566-609 7e-09

1edmB 608-644 3e-10

1autL1 642-684 1e-11

1edmB 681-711 4e-08

1autL1 716-759 1e-07

5mwbA1 757-795 2e-08

1edmB 794-832 3e-11

1g1tA2 835-874 3e-04

5mwbA1 873-911 2e-08

1edmB 911-948 9e-11

1edmB 948-985 4e-11

1edmB 987-1022 6e-09

1edmB 1025-1062 3e-11

1edmB 1151-1185 9e-11

1edmB 1187-1223 5e-09

1edmB 1225-1262 2e-07

1edmB 1264-1303 3e-05

5mwbA1 1312-1343 1e-04

1egfA 1378-1412 6e-04

1pb5A 1424-1456 4e-06

2f8yA 1858-2071 1e-82

SCOP Hmmer

1haeA_ 27-64 1.1e-06

1gk5A_ 65-105 6.1e-10

1p9jA_ 108-144 7.5e-09

1ffmA_ 146-187 1.4e-11

1uzpA2 181-219 5.2e-10

1haeA_ 222-264 1.1e-09

1haeA_ 260-307 2e-12

1tozA1 298-336 1.5e-10

2dtgE6 325-461 2.9e-12

2dtgE6 413-536 2.3e-14

2dtgE6 529-643 1.3e-12

2dtgE6 594-725 1.7e-14

2dtgE6 669-799 4.2e-14

2dtgE6 782-915 1.8e-14

1ffmA_ 911-954 1.4e-14

1ffmA_ 948-991 1e-13

1dvaL1 983-1026 5.2e-11

2dtgE6 1013-1153 1.1e-13

1ffmA_ 1149-1191 3e-13

2dtgE6 1174-1308 2.5e-14

1haeA_ 1305-1344 2.3e-09

1egfA_ 1377-1415 2.5e-09

1pb5A_ 1424-1456 3.4e-09

1pb5A_ 1466-1497 4.5e-05

1pb5A_ 1503-1534 1.1e-08

1s70B_ 1820-2066 7.9e-54

Pfam RPS-Blast

PF00008 264-292 7e-04 EGF-like domain

PF00008 460-490 4e-04 EGF-like domain

PF00008 498-527 5e-05 EGF-like domain

PF00008 536-564 5e-05 EGF-like domain

PF00008 761-789 4e-05 EGF-like domain

PF00008 799-829 4e-05 EGF-like domain

PF00012 829-1373 3e-05 Hsp70 protein

PF00066 1427-1455 5e-04 LNR domain

PF00066 1501-1535 1e-04 LNR domain

PF06816 1539-1594 1e-22 NOTCH protein

PF07684 1620-1673 2e-12 NOTCH protein

PF13857 1867-1915 2e-09 Ankyrin repeats (many cop...

PF13857 1896-1951 3e-07 Ankyrin repeats (many cop...

PF13857 1963-2017 1e-09 Ankyrin repeats (many cop...

PF11936 2382-2443 2e-17 Domain of unknown functio...

Pfam Hmmer

PF00008 68-99 1.3e-09 EGF-like domain

PF00008 113-140 1.2e-10 EGF-like domain

PF00008 148-177 4.8e-08 EGF-like domain

PF07645 182-214 8.1e-12 Calcium-binding EGF domain

PF12661 230-252 1.6e-05 Human growth factor-like E...

PF00008 264-292 1.1e-08 EGF-like domain

PF07645 298-331 4.1e-11 Calcium-binding EGF domain

PF12661 347-367 2.2e-05 Human growth factor-like E...

PF00008 379-410 2.4e-08 EGF-like domain

PF07645 415-449 2.1e-11 Calcium-binding EGF domain

PF00008 460-489 3.3e-10 EGF-like domain

PF00008 498-527 1e-10 EGF-like domain

PF00008 536-564 2e-12 EGF-like domain

PF12661 579-599 4.6e-08 Human growth factor-like E...

PF00008 611-639 1.9e-09 EGF-like domain

PF00008 649-678 1.5e-10 EGF-like domain

PF00008 686-711 3.1e-08 EGF-like domain

PF00008 761-789 3.6e-10 EGF-like domain

PF00008 799-829 1.9e-11 EGF-like domain

PF00008 837-869 1.8e-10 EGF-like domain

PF07645 873-904 6.5e-11 Calcium-binding EGF domain

PF00008 915-944 1.3e-11 EGF-like domain

PF00008 953-982 2e-10 EGF-like domain

PF00008 991-1020 3.4e-10 EGF-like domain

PF00008 1029-1059 9.4e-13 EGF-like domain

PF00008 1067-1097 3.2e-08 EGF-like domain

PF00008 1120-1145 9.4e-09 EGF-like domain

PF00008 1153-1182 9.4e-11 EGF-like domain

PF00008 1191-1219 4.4e-10 EGF-like domain

PF00008 1229-1260 2.5e-10 EGF-like domain

PF00008 1308-1341 1.2e-10 EGF-like domain

PF00066 1423-1456 2.8e-14 LNR domain

PF00066 1463-1497 9e-11 LNR domain

PF00066 1501-1534 1.2e-14 LNR domain

PF06816 1539-1594 2e-28 NOTCH protein

PF07684 1618-1671 2.9e-20 NOTCH protein

PF00023 1827-1874 1.2e-08 Ankyrin repeat

PF12796 1881-1974 4.5e-13 Ankyrin repeats (3 copie...

PF12796 1948-2039 2.3e-15 Ankyrin repeats (3 copie...

PF11936 2382-2444 5.1e-30 Domain of unknown functi...