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IID00467
 UniprotQ13029
ProteinPR domain zinc finger protein 2
GenePRDM2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1718
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-161 Monomer :
 Evidence X-RAY 2qpw A Reference
       Region 2qpw A 2-148 order
 Evidence NMR 2jv0 A Reference
       Region 2jv0 A 1-161 order
       Region 2jv0 A 1-10 high_rmsd
       Region 2jv0 A 38-38 high_rmsd
       Region 2jv0 A 70-72 high_rmsd
       Region 2jv0 A 142-146 high_rmsd
       Region 2jv0 A 153-161 high_rmsd
Seqphosphorylation
    421-421 Phosphoserine
    643-643 Phosphoserine
    743-743 Phosphoserine
    781-781 Phosphoserine
    785-785 Phosphoserine
    796-796 Phosphoserine
 
Prediction
NeProc
Disorder 1-14,160-255,296-359,406-478,483-494,499-603,616-1126,1235-1326,1366-1421,1450-1450,1475-1718
Order 15-159,256-295,360-405,479-482,495-498,604-615,1127-1234,1327-1365,1422-1449,1451-1474
ProS 1-14,160-255,296-317,330-359,406-429,437-461,469-478,483-494,499-519,536-560,567-589,594-603,639-655,676-698,706-713,732-737,816-830,840-854,880-902,1036-1043,1101-1117,1122-1126,1235-1326,1366-1421,1450-1450,1475-1490,1498-1524,1530-1546,1555-1558,1581-1585,1636-1652,1678-1687,1694-1703,1711-1718
AlphaFold
Disorder 1-11,141-149,152-152,156-156,159-358,383-389,414-481,507-1132,1186-1189,1216-1220,1222-1270,1272-1273,1275-1333,1359-1428,1430-1430,1432-1454,1482-1718
Order 12-140,150-151,153-155,157-158,359-382,390-413,482-506,1133-1185,1190-1215,1221-1221,1271-1271,1274-1274,1334-1358,1429-1429,1431-1431,1455-1481
Pfam Hmmer
PF00856 22-147 2.9e-08
PF00096 360-382 3e-05
PF00096 390-412 1.9e-05
PF00096 483-506 0.00015
PF00096 1191-1214 0.00082
SEG 145-184 ,265-296 ,522-533 ,658-672 ,687-702 ,730-748 ,951-1012 ,1018-1039 ,1042-1087 ,1258-1269 ,1409-1428 ,1477-1512 ,1562-1577 ,1705-1716
Function
Function in SwissProt
S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.