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IID00470
 UniprotQ13469
ProteinNuclear factor of activated T-cells, cytoplasmic 2
GeneNFATC2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
925
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 391-678 Homo dimer :
 Evidence X-RAY 1p7h L Reference
       Region 1p7h L 393-678 order
 Evidence X-RAY 1p7h M Reference
       Region 1p7h M 393-678 order
 Evidence X-RAY 1p7h N Reference
       Region 1p7h N 393-678 order
 Evidence X-RAY 1p7h O Reference
       Region 1p7h O 393-678 order
 Evidence X-RAY 1pzu B Reference
       Region 1pzu B 396-398 disorder
       Region 1pzu B 399-571 order
       Region 1pzu B 572-575 disorder
       Region 1pzu B 576-678 order
 Evidence X-RAY 1pzu D Reference
       Region 1pzu D 396-398 disorder
       Region 1pzu D 399-571 order
       Region 1pzu D 572-575 disorder
       Region 1pzu D 576-678 order
 Evidence X-RAY 1pzu H Reference
       Region 1pzu H 396-398 disorder
       Region 1pzu H 399-571 order
       Region 1pzu H 572-575 disorder
       Region 1pzu H 576-678 order
 Evidence X-RAY 1pzu I Reference
       Region 1pzu I 396-398 disorder
       Region 1pzu I 399-571 order
       Region 1pzu I 572-575 disorder
       Region 1pzu I 576-678 order
 Evidence X-RAY 1pzu L Reference
       Region 1pzu L 396-398 disorder
       Region 1pzu L 399-571 order
       Region 1pzu L 572-575 disorder
       Region 1pzu L 576-678 order
 Evidence X-RAY 1pzu M Reference
       Region 1pzu M 396-398 disorder
       Region 1pzu M 399-571 order
       Region 1pzu M 572-575 disorder
       Region 1pzu M 576-678 order
 Evidence X-RAY 8ow4 A Reference
       Region 8ow4 A 391-394 disorder
       Region 8ow4 A 395-480 order
       Region 8ow4 A 481-483 disorder
       Region 8ow4 A 484-553 order
       Region 8ow4 A 554-555 disorder
       Region 8ow4 A 556-584 order
       Region 8ow4 A 585-596 disorder
       Region 8ow4 A 597-603 order
       Region 8ow4 A 604-605 disorder
       Region 8ow4 A 606-613 order
       Region 8ow4 A 614-621 disorder
       Region 8ow4 A 622-628 order
       Region 8ow4 A 629-632 disorder
       Region 8ow4 A 633-633 order
       Region 8ow4 A 634-652 disorder
       Region 8ow4 A 653-663 order
       Region 8ow4 A 664-665 disorder
       Region 8ow4 A 666-671 order
       Region 8ow4 A 672-678 disorder
 Evidence X-RAY 8ow4 B Reference
       Region 8ow4 B 391-678 order
Seq 392-678 Hetero dimer : IID00429Complex
 Evidence X-RAY 2as5 N Reference
       Region 2as5 N 392-678 order
 Evidence X-RAY 2as5 M Reference
       Region 2as5 M 392-678 order
Seq 392-678 Hetero trimer : IID00436Complex,IID00437Complex
 Evidence X-RAY 1a02 N Reference
       Region 1a02 N 392-398 disorder
       Region 1a02 N 399-678 order
 Evidence X-RAY 1s9k C Reference
       Region 1s9k C 399-678 order
Seq 396-678 Homo trimer :
 Evidence X-RAY 2o93 L Reference
       Region 2o93 L 396-678 order
 Evidence X-RAY 2o93 M Reference
       Region 2o93 M 396-678 order
 Evidence X-RAY 2o93 O Reference
       Region 2o93 O 396-678 order
Seq 396-678 Monomer :
 Evidence X-RAY 1owr M Reference
       Region 1owr M 396-678 order
 Evidence X-RAY 1owr N Reference
       Region 1owr N 396-678 order
 Evidence X-RAY 1owr P Reference
       Region 1owr P 396-678 order
 Evidence X-RAY 1owr Q Reference
       Region 1owr Q 396-678 order
Seq 396-678 Hetero trimer : IID00497Complex
 Evidence X-RAY 3qrf N Reference
       Region 3qrf N 396-678 order
 Evidence X-RAY 3qrf M Reference
       Region 3qrf M 396-678 order
SeqProS possible 522-537 Same region of the homolog (O95644, 84% identity) is disordered in the free state. This region binds to DNA. Homo trimer :
       Region 2o93 L 396-678 order
       Region 2o93 M 396-678 order
       Region 2o93 O 396-678 order
SeqProS possible 522-537 Same region of the homolog (O95644, 84% identity) is disordered in the free state. This region binds to DNA. Hetero trimer : IID00497Complex
       Region 3qrf M 396-678 order
       Region 3qrf N 396-678 order
SeqProS possible 522-537 Same region of the homolog (O95644, 84% identity) is disordered in the free state. This region binds to DNA. Hetero dimer : IID00429Complex
       Region 2as5 M 392-678 order
       Region 2as5 N 392-678 order
SeqProS possible 522-537 Same region of the homolog (O95644, 84% identity) is disordered in the free state. This region binds to DNA. :
       Region 1owr M 396-678 order
       Region 1owr N 396-678 order
       Region 1owr P 396-678 order
       Region 1owr Q 396-678 order
SeqProS possible 522-537 Same region of the homolog (O95644, 84% identity) is disordered in the free state. This region binds to DNA. Hetero trimer : IID00436Complex,IID00437Complex
       Region 1a02 N 399-678 order
       Region 1s9k C 399-678 order
SeqProS possible 522-537 Same region of the homolog (O95644, 84% identity) is disordered in the free state. This region binds to DNA. Homo dimer :
       Region 1pzu B 399-571 order
       Region 1pzu D 399-571 order
       Region 1pzu H 399-571 order
       Region 1pzu I 399-571 order
       Region 1pzu L 399-571 order
       Region 1pzu M 399-571 order
       Region 1p7h L 393-678 order
       Region 1p7h M 393-678 order
       Region 1p7h N 393-678 order
       Region 1p7h O 393-678 order
       Region 8ow4 A 484-553 order
       Region 8ow4 B 391-678 order
Seqphosphorylation
    859-859 Phosphoserine
    856-856 Phosphoserine
    759-759 Phosphoserine
    757-757 Phosphoserine
    755-755 Phosphoserine
    363-363 Phosphoserine
    330-330 Phosphoserine
    326-326 Phosphoserine
    280-280 Phosphoserine
    276-276 Phosphoserine
    274-274 Phosphoserine
    268-268 Phosphoserine
    255-255 Phosphoserine
    243-243 Phosphoserine
    236-236 Phosphoserine
    221-221 Phosphoserine
    217-217 Phosphoserine
    213-213 Phosphoserine
    180-180 Phosphoserine
    177-177 Phosphoserine
    175-175 Phosphoserine
    174-174 Phosphoserine
    172-172 Phosphoserine
    171-171 Phosphoserine
    168-168 Phosphoserine
    148-148 Phosphoserine
    110-110 Phosphoserine
    107-107 Phosphoserine
    99-99 Phosphoserine
    23-23 Phosphoserine
    23-23 Phosphoserine
    99-99 Phosphoserine
    107-107 Phosphoserine
    110-110 Phosphoserine
    148-148 Phosphoserine
    168-168 Phosphoserine
    171-171 Phosphoserine
    172-172 Phosphoserine
    174-174 Phosphoserine
    175-175 Phosphoserine
    177-177 Phosphoserine
    180-180 Phosphoserine
    213-213 Phosphoserine
    217-217 Phosphoserine
    221-221 Phosphoserine
    236-236 Phosphoserine
    243-243 Phosphoserine
    255-255 Phosphoserine
    268-268 Phosphoserine
    274-274 Phosphoserine
    276-276 Phosphoserine
    280-280 Phosphoserine
    326-326 Phosphoserine
    330-330 Phosphoserine
    363-363 Phosphoserine
    755-755 Phosphoserine
    757-757 Phosphoserine
    759-759 Phosphoserine
    856-856 Phosphoserine
    859-859 Phosphoserine
 
Prediction
NeProc
Disorder 1-394,427-433,678-897,921-925
Order 395-426,434-677,898-920
ProS 1-53,59-67,110-121,141-164,175-203,218-232,281-288,312-329,364-394,427-433,889-897,921-925
AlphaFold
Disorder 1-392,531-536,572-575,682-900,902-902,917-925
Order 393-530,537-571,576-681,901-901,903-916
Pfam Hmmer
PF00554 410-570 1.1e-51
PF01833 578-676 1.5e-16
SEG 40-47 ,168-185 ,234-253 ,264-281 ,326-339
Function
Function in SwissProt
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258).
Biological Process
Diagram with PDB data
NFATC2/FOXP3/DNAStructure of a domain-swapped FOXP3 dimer
NFATC2/FOXP2/DNAStructure of the DNA binding domains of NFAT and FOXP2 bound specifically to DNA.
NFATC2/FOS/JUN/DNASTRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA