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IID00471
 UniprotQ13568
ProteinInterferon regulatory factor 5
GeneIRF5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
498
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 232-477 Homo dimer :
 Evidence X-RAY 3dsh A Reference
       Region 3dsh A 232-467 order
       Region 3dsh A 468-477 disorder
Seqphosphorylation
    437-437 Phosphoserine
    10-10 Phosphothreonine
    158-158 Phosphoserine; by TBK1
    293-293 Phosphoserine; by TBK1
    301-301 Phosphoserine
    431-431 Phosphoserine
    435-435 Phosphoserine
    440-440 Phosphoserine
    446-446 Phosphoserine; by IKKB
 
Prediction
NeProc
Disorder 1-14,76-79,102-105,125-245,284-303,349-356,438-498
Order 15-75,80-101,106-124,246-278,304-348,357-437
ProS 76-79,102-105,131-139,182-200,205-211,223-241,284-303,438-447,454-468,477-498
AlphaFold
Disorder 1-14,50-60,106-113,123-244,354-355,432-444,446-446,470-498
Order 15-49,61-105,114-122,245-353,356-431,445-445,447-469
Pfam Hmmer
PF00605 14-123 6.5e-46
SEG 142-149 ,166-209 ,219-232
Function
Function in SwissProt
Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.