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IID00474
 UniprotQ14934
ProteinNuclear factor of activated T-cells, cytoplasmic 4
GeneNFATC4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
902
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 585-691 Monomer :
 Evidence NMR 2yrp A Reference
       Region 2yrp A 585-691 order
       Region 2yrp A 689-691 high_rmsd
Seqphosphorylation
    168-168 Phosphoserine; by MAPK7 and MAPK14
    170-170 Phosphoserine; by MAPK7 and MAPK14
    213-213 Phosphoserine; by MAPK8 and MAPK9
    217-217 Phosphoserine; by MAPK8 and MAPK9
    289-289 Phosphoserine; by RPS6KA3
    344-344 Phosphoserine; by RPS6KA3
 
Prediction
NeProc
Disorder 1-416,491-495,541-544,689-873,879-902
Order 417-490,496-540,545-688,874-878
ProS 1-22,33-50,57-65,85-96,108-123,135-159,183-232,240-249,264-275,282-293,323-335,353-387,393-399,407-416,491-495,541-544,870-873,879-893
AlphaFold
Disorder 1-196,205-394,539-545,580-583,688-876,879-879,883-883,886-902
Order 197-204,395-538,546-579,584-687,877-878,880-882,884-885
Pfam Hmmer
PF00554 419-578 8.9e-52
PF01833 586-684 1.6e-19
SEG 22-35 ,51-82 ,96-108 ,151-190 ,210-224 ,272-312 ,716-726 ,793-828 ,844-857 ,891-902
Function
Function in SwissProt
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.