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IID00475
 UniprotQ14994
ProteinNuclear receptor subfamily 1 group I member 3
GeneNR1I3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
352
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 103-231,236-352 Hetero tetramer : IID00031Complex,IID00083Complex
 Evidence X-RAY 1xvp D Reference
       Region 1xvp D 103-231 order
       Region 1xvp D 236-352 order
 Evidence X-RAY 1xvp B Reference
       Region 1xvp B 103-231 order
       Region 1xvp B 236-352 order
 Evidence X-RAY 1xv9 D Reference
       Region 1xv9 D 103-231 order
       Region 1xv9 D 236-352 order
 Evidence X-RAY 1xv9 B Reference
       Region 1xv9 B 103-231 order
       Region 1xv9 B 236-352 order
Seqphosphorylation
    38-38 Phosphothreonine; by PKC
 
Prediction
NeProc
Disorder 1-6,85-110
Order 7-84,111-140,154-352
ProS 85-89
AlphaFold
Disorder 1-7,146-152,232-236,304-309
Order 8-145,153-231,237-303,310-352
Pfam Hmmer
PF00105 9-84 9.4e-43
PF00104 166-350 1.7e-41
SEG 84-101 ,147-159 ,312-323
Function
Function in SwissProt
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment