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IID00479
 UniprotQ32MZ4
ProteinLeucine-rich repeat flightless-interacting protein 1
GeneLRRFIP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
808
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 162-249 Homo dimer :
 Evidence X-RAY 4h22 D Reference
       Region 4h22 D 162-169 disorder
       Region 4h22 D 170-243 order
       Region 4h22 D 244-249 disorder
 Evidence X-RAY 4h22 C Reference
       Region 4h22 C 162-169 disorder
       Region 4h22 C 170-243 order
       Region 4h22 C 244-249 disorder
 Evidence X-RAY 4h22 B Reference
       Region 4h22 B 162-166 disorder
       Region 4h22 B 167-249 order
 Evidence X-RAY 4h22 A Reference
       Region 4h22 A 162-167 disorder
       Region 4h22 A 168-248 order
       Region 4h22 A 249-249 disorder
Seqdisorder 250-808
 Evidence CD Reference
       Region 250-808 disorder
Seqphosphorylation
    714-714 Phosphoserine
    618-618 Phosphoserine
    16-16 Phosphoserine
    115-115 Phosphoserine
    116-116 Phosphoserine
    120-120 Phosphoserine
    124-124 Phosphoserine
    555-555 Phosphoserine
    564-564 Phosphoserine
    581-581 Phosphoserine
    638-638 Phosphoserine
    676-676 Phosphothreonine
    733-733 Phosphoserine
    766-766 Phosphoserine
    768-768 Phosphoserine
Seqacetylation
    2-2 N-acetylthreonine
 
Prediction
NeProc
Disorder 1-25,61-138,259-808
Order 26-60,139-258
ProS 1-25,61-64,70-95,123-130,259-326,333-349,359-381,387-390,467-472,586-603,612-614,627-631,640-658,765-808
AlphaFold
Disorder 1-15,61-126,255-808
Order 16-60,127-254
SEG 18-39 ,54-68 ,110-127 ,500-505 ,567-580
Function
Function in SwissProt
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.