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IID00485
 UniprotQ8IZD2
ProteinInactive histone-lysine N-methyltransferase 2E
GeneKMT2E
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1858
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 109-188 Monomer :
 Evidence NMR 2lv9 A Reference
       Region 2lv9 A 109-188 order
       Region 2lv9 A 109-115 high_rmsd
       Region 2lv9 A 186-188 high_rmsd
Seq 117-181 Hetero dimer : IID00239Complex
 Evidence X-RAY 4l58 A Reference
       Region 4l58 A 117-181 order
Seq 323-458 Monomer :
 Evidence X-RAY 5ht6 A Reference
       Region 5ht6 A 323-326 disorder
       Region 5ht6 A 327-331 order
       Region 5ht6 A 332-339 disorder
       Region 5ht6 A 340-457 order
       Region 5ht6 A 458-458 disorder
 Evidence X-RAY 5ht6 B Reference
       Region 5ht6 B 323-339 disorder
       Region 5ht6 B 340-448 order
       Region 5ht6 B 449-458 disorder
Seqphosphorylation
    623-623 Phosphoserine
    837-837 Phosphoserine
    845-845 Phosphoserine
    1070-1070 Phosphoserine
    1273-1273 Phosphoserine
    1359-1359 Phosphoserine
 
Prediction
NeProc
Disorder 1-116,181-270,313-320,475-559,619-1858
Order 117-180,271-312,321-474,560-618
ProS 1-40,55-69,86-96,181-185,210-218,266-270,313-320,475-489,496-501,509-513,720-734,815-821,941-947,967-970,1073-1090,1251-1269,1834-1858
AlphaFold
Disorder 1-116,184-274,308-327,372-378,463-464,475-567,570-572,605-1160,1162-1162,1165-1165,1167-1260,1269-1858
Order 117-183,275-307,328-371,379-462,465-474,568-569,573-604,1161-1161,1163-1164,1166-1166,1261-1268
Pfam Hmmer
PF00628 120-166 6.5e-15
PF00856 324-454 2.9e-29
SEG 23-38 ,48-55 ,70-81 ,100-109 ,490-503 ,569-582 ,698-716 ,882-901 ,933-945 ,951-960 ,1285-1303 ,1323-1337 ,1349-1362 ,1544-1555 ,1622-1636 ,1675-1696 ,1715-1723
Function
Function in SwissProt
Isoform NKp44L
Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity.