Search Keyword:


Search option:


IID00493
UniprotQ969V6
ProteinMKL/myocardin-like protein 1
GeneMRTFA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
931
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 336-396 Monomer :
 Evidence NMR 2kw9 A Reference
       Region 2kw9 A 336-396 order
       Region 2kw9 A 336-340 high_rmsd
       Region 2kw9 A 387-396 high_rmsd
 Evidence NMR 2kvu A Reference
       Region 2kvu A 336-396 order
       Region 2kvu A 336-339 high_rmsd
       Region 2kvu A 386-396 high_rmsd
Seqphosphorylation
    492-492 Phosphoserine
    6-6 Phosphoserine
    124-124 Phosphoserine
    139-139 Phosphoserine
    156-156 Phosphoserine
    859-859 Phosphoserine
    807-807 Phosphoserine
    792-792 Phosphoserine
    695-695 Phosphoserine
    691-691 Phosphoserine
    685-685 Phosphoserine
    511-511 Phosphoserine
    507-507 Phosphoserine
    305-305 Phosphothreonine
    482-482 Phosphoserine
    458-458 Phosphoserine
    456-456 Phosphothreonine
    454-454 Phosphoserine
    450-450 Phosphothreonine
    449-449 Phosphoserine
    447-447 Phosphothreonine
    446-446 Phosphoserine
    385-385 Phosphoserine
    333-333 Phosphoserine
    320-320 Phosphoserine
    317-317 Phosphoserine
    313-313 Phosphothreonine
    312-312 Phosphoserine
    310-310 Phosphoserine
 
Prediction
NeProc
Disorder 1-522,562-911,917-920,928-931
Order 523-561,912-916,921-927
ProS 1-49,62-114,117-124,750-755,808-816,838-853,864-868,877-895,917-920,928-931
AlphaFold
Disorder 94-96,98-99,102-234,236-236,244-256,280-341,385-520,562-660,662-662,664-664,666-744,765-814,818-819,821-838,849-931
Order 1-93,97-97,100-101,235-235,237-243,257-279,342-384,521-561,661-661,663-663,665-665,745-764,815-817,820-820,839-848
Pfam Hmmer
PF02755 24-49 0.001
PF02755 68-93 0.00083
PF02037 347-381 9.3e-14
SEG 111-124 ,180-190 ,224-237 ,263-281 ,310-320 ,418-442 ,445-458 ,561-570 ,638-647 ,678-703 ,784-812
Function
Function in SwissProt
Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation.