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IID00494
 UniprotQ96RT1
ProteinErbin
GeneERBIN
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1412
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1314-1412 Hetero dimer :
 Evidence NMR 1n7t A Reference
       Region 1n7t A 1314-1412 order
       Region 1n7t A 1314-1317 high_rmsd
Seq 1314-1412 Monomer :
 Evidence X-RAY 2h3l A Reference
       Region 2h3l A 1314-1412 order
 Evidence X-RAY 2h3l B Reference
       Region 2h3l B 1314-1411 order
       Region 2h3l B 1412-1412 disorder
Seq 1318-1410 Hetero dimer :
 Evidence X-RAY 3ch8 A Reference
       Region 3ch8 A 1318-1327 order
       Region 3ch8 A 1328-1328 disorder
       Region 3ch8 A 1329-1409 order
       Region 3ch8 A 1410-1410 disorder
Seq 1321-1412 Hetero dimer : IID00293Complex
 Evidence X-RAY 1mfg A Reference
       Region 1mfg A 1321-1412 order
 Evidence X-RAY 1mfl A Reference
       Region 1mfl A 1321-1412 order
Seq 1330-1410 Hetero dimer :
 Evidence X-RAY 2qbw A Reference
       Region 2qbw A 1330-1410 order
Seqphosphorylation
    603-603 Phosphoserine
    620-620 Phosphoserine
    602-602 Phosphoserine
    598-598 Phosphoserine
    569-569 Phosphoserine
    485-485 Phosphothreonine
    483-483 Phosphotyrosine
    444-444 Phosphoserine
    440-440 Phosphoserine
    852-852 Phosphoserine
    1158-1158 Phosphoserine
    1179-1179 Phosphoserine
    1286-1286 Phosphoserine
    972-972 Phosphotyrosine
    931-931 Phosphoserine
    920-920 Phosphotyrosine
    917-917 Phosphothreonine
    872-872 Phosphoserine
    857-857 Phosphoserine
    1104-1104 Phosphotyrosine
    715-715 Phosphoserine
 
Prediction
NeProc
Disorder 1-5,431-730,737-1319
Order 6-430,731-736,1320-1339,1344-1412
ProS 446-452,458-464,477-511,525-535,581-597,603-616,623-657,688-712,718-722,737-751,757-783,791-836,845-894,906-913,918-929,942-951,975-981,989-1001,1027-1042,1056-1061,1073-1077,1096-1105,1127-1132,1155-1165,1196-1211,1221-1229,1237-1259,1268-1275
AlphaFold
Disorder 1-22,432-492,500-500,507-1318,1343-1344,1411-1412
Order 23-431,493-499,501-506,1319-1342,1345-1410
Pfam Hmmer
PF00595 1323-1407 7.8e-15
SEG 254-268 ,533-546 ,596-606 ,650-662 ,930-934 ,1333-1344
Function
Function in SwissProt
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).
Biological Process
See also
Diagram with PDB data
ERBB2/ERBINThe Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor