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IID00500
 UniprotQ9H9B1
ProteinHistone-lysine N-methyltransferase EHMT1
GeneEHMT1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1298
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 672-999 Monomer :
 Evidence X-RAY 3b7b A Reference
       Region 3b7b A 765-998 order
       Region 3b7b A 999-999 disorder
 Evidence X-RAY 3b7b B Reference
       Region 3b7b B 765-774 disorder
       Region 3b7b B 775-998 order
       Region 3b7b B 999-999 disorder
 Evidence X-RAY 6by9 A Reference
       Region 6by9 A 672-730 disorder
       Region 6by9 A 731-998 order
       Region 6by9 A 999-999 disorder
Seq 765-999 Hetero trimer : IID00062Complex
 Evidence X-RAY 3b95 A Reference
       Region 3b95 A 765-998 order
       Region 3b95 A 999-999 disorder
 Evidence X-RAY 3b95 B Reference
       Region 3b95 B 765-773 disorder
       Region 3b95 B 774-998 order
       Region 3b95 B 999-999 disorder
Seq 982-1266 Monomer :
 Evidence X-RAY 3mo0 A Reference
       Region 3mo0 A 982-1007 disorder
       Region 3mo0 A 1008-1048 order
       Region 3mo0 A 1049-1055 disorder
       Region 3mo0 A 1056-1265 order
       Region 3mo0 A 1266-1266 disorder
 Evidence X-RAY 3mo0 B Reference
       Region 3mo0 B 982-1008 disorder
       Region 3mo0 B 1009-1082 order
       Region 3mo0 B 1083-1098 disorder
       Region 3mo0 B 1099-1266 order
 Evidence X-RAY 3mo2 A Reference
       Region 3mo2 A 982-1008 disorder
       Region 3mo2 A 1009-1178 order
       Region 3mo2 A 1179-1181 disorder
       Region 3mo2 A 1182-1266 order
 Evidence X-RAY 3mo2 B Reference
       Region 3mo2 B 982-1006 disorder
       Region 3mo2 B 1007-1180 order
       Region 3mo2 B 1181-1182 disorder
       Region 3mo2 B 1183-1266 order
 Evidence X-RAY 3mo2 C Reference
       Region 3mo2 C 982-1005 disorder
       Region 3mo2 C 1006-1178 order
       Region 3mo2 C 1179-1181 disorder
       Region 3mo2 C 1182-1266 order
 Evidence X-RAY 3mo2 D Reference
       Region 3mo2 D 982-1006 disorder
       Region 3mo2 D 1007-1178 order
       Region 3mo2 D 1179-1182 disorder
       Region 3mo2 D 1183-1266 order
 Evidence X-RAY 3mo5 A Reference
       Region 3mo5 A 982-1008 disorder
       Region 3mo5 A 1009-1178 order
       Region 3mo5 A 1179-1181 disorder
       Region 3mo5 A 1182-1266 order
 Evidence X-RAY 3mo5 B Reference
       Region 3mo5 B 982-1006 disorder
       Region 3mo5 B 1007-1180 order
       Region 3mo5 B 1181-1182 disorder
       Region 3mo5 B 1183-1266 order
 Evidence X-RAY 3mo5 C Reference
       Region 3mo5 C 982-1005 disorder
       Region 3mo5 C 1006-1178 order
       Region 3mo5 C 1179-1181 disorder
       Region 3mo5 C 1182-1266 order
 Evidence X-RAY 3mo5 D Reference
       Region 3mo5 D 982-1006 disorder
       Region 3mo5 D 1007-1178 order
       Region 3mo5 D 1179-1182 disorder
       Region 3mo5 D 1183-1266 order
 Evidence X-RAY 5ttg A Reference
       Region 5ttg A 982-1005 disorder
       Region 5ttg A 1006-1179 order
       Region 5ttg A 1180-1180 disorder
       Region 5ttg A 1181-1266 order
 Evidence X-RAY 5ttg B Reference
       Region 5ttg B 982-1005 disorder
       Region 5ttg B 1006-1178 order
       Region 5ttg B 1179-1181 disorder
       Region 5ttg B 1182-1266 order
Seq 982-1266 Hetero dimer :
 Evidence X-RAY 2rfi A This region binds to Histone H3. Reference
       Region 2rfi A 982-1005 disorder
       Region 2rfi A 1006-1266 order
Seq 982-1266 Homo dimer :
 Evidence X-RAY 2igq A Reference
       Region 2igq A 982-1006 disorder
       Region 2igq A 1007-1177 order
       Region 2igq A 1178-1183 disorder
       Region 2igq A 1184-1251 order
       Region 2igq A 1252-1254 disorder
       Region 2igq A 1255-1266 order
 Evidence X-RAY 2igq B Reference
       Region 2igq B 982-1006 disorder
       Region 2igq B 1007-1178 order
       Region 2igq B 1179-1182 disorder
       Region 2igq B 1183-1250 order
       Region 2igq B 1251-1252 disorder
       Region 2igq B 1253-1266 order
 Evidence X-RAY 3fpd A Reference
       Region 3fpd A 1006-1266 order
 Evidence X-RAY 3fpd B Reference
       Region 3fpd B 1006-1006 disorder
       Region 3fpd B 1007-1266 order
 Evidence X-RAY 5tuz A Reference
       Region 5tuz A 1006-1179 order
       Region 5tuz A 1180-1181 disorder
       Region 5tuz A 1182-1266 order
 Evidence X-RAY 5tuz B Reference
       Region 5tuz B 1006-1178 order
       Region 5tuz B 1179-1182 disorder
       Region 5tuz B 1183-1266 order
 Evidence X-RAY 5vsd A Reference
       Region 5vsd A 1006-1178 order
       Region 5vsd A 1179-1182 disorder
       Region 5vsd A 1183-1266 order
 Evidence X-RAY 5vsd B Reference
       Region 5vsd B 1006-1178 order
       Region 5vsd B 1179-1181 disorder
       Region 5vsd B 1182-1266 order
 Evidence X-RAY 5vsf A Reference
       Region 5vsf A 1006-1266 order
 Evidence X-RAY 5vsf B Reference
       Region 5vsf B 1006-1178 order
       Region 5vsf B 1179-1181 disorder
       Region 5vsf B 1182-1266 order
Seq 982-1266 Hetero tetramer : IID00062Complex
 Evidence X-RAY 4i51 A Reference
       Region 4i51 A 982-1005 disorder
       Region 4i51 A 1006-1266 order
 Evidence X-RAY 4i51 B Reference
       Region 4i51 B 982-1003 disorder
       Region 4i51 B 1004-1178 order
       Region 4i51 B 1179-1183 disorder
       Region 4i51 B 1184-1266 order
Seq 982-1266 Hetero dimer :
 Evidence X-RAY 2rfi B This region binds to Histone H3. Reference
       Region 2rfi B 982-1008 disorder
       Region 2rfi B 1009-1177 order
       Region 2rfi B 1178-1183 disorder
       Region 2rfi B 1184-1266 order
Seq 982-1266 Hetero dimer :
 Evidence X-RAY 3hna A This region binds to Histone H3. Reference
       Region 3hna A 982-995 order
       Region 3hna A 996-1002 disorder
       Region 3hna A 1003-1266 order
Seq 982-1266 Hetero dimer : IID50163Complex
 Evidence X-RAY 3sw9 A Reference
       Region 3sw9 A 982-1005 disorder
       Region 3sw9 A 1006-1266 order
 Evidence X-RAY 3sw9 B Reference
       Region 3sw9 B 982-1005 disorder
       Region 3sw9 B 1006-1266 order
 Evidence X-RAY 3swc A Reference
       Region 3swc A 982-1005 disorder
       Region 3swc A 1006-1266 order
 Evidence X-RAY 3swc B Reference
       Region 3swc B 982-1005 disorder
       Region 3swc B 1006-1266 order
Seq 982-1266 Hetero dimer :
 Evidence X-RAY 3hna B This region binds to Histone H3. Reference
       Region 3hna B 982-1006 disorder
       Region 3hna B 1007-1266 order
Seqphosphorylation
    435-435 Phosphoserine
    483-483 Phosphoserine
    1004-1004 Phosphoserine
    1048-1048 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-516,650-712,998-1007,1272-1298
Order 517-529,537-647,713-997,1008-1271
ProS 5-25,52-68,89-99,107-129,137-140,148-154,198-205,306-319,338-346,373-377,433-439,476-480,486-489,513-516,666-680,690-712,998-1007,1272-1277
AlphaFold
Disorder 1-519,522-528,644-735,862-862,999-1006,1181-1181,1279-1298
Order 520-521,529-643,736-861,863-998,1007-1180,1182-1278
Pfam Hmmer
PF00023 772-804 1.2e-06
PF00023 805-837 2.5e-08
PF00023 838-871 7.2e-08
PF00023 872-904 8.1e-08
PF00023 905-937 0.00012
PF00023 938-970 1.3e-06
PF05033 1013-1118 8.9e-34
PF00856 1120-1250 1.2e-53
SEG 164-178 ,342-360 ,392-421 ,439-453 ,1266-1282
Function
Function in SwissProt
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity).
Biological Process
See also
Diagram with PDB data
EHMT2/CBX3Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide