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IID00535
 UniprotP04629
ProteinHigh affinity nerve growth factor receptor
GeneNTRK1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
796
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 36-382 Hetero tetramer : P01138
 Evidence X-RAY 2ifg B Reference
       Region 2ifg B 36-382 order
 Evidence X-RAY 2ifg A Reference
       Region 2ifg A 36-382 order
Seq 278-413 Monomer :
 Evidence NMR 4crp A Reference
       Region 4crp A 282-383 order
       Region 4crp A 381-383 high_rmsd
 Evidence X-RAY 1wwa X Reference
       Region 1wwa X 278-281 disorder
       Region 1wwa X 282-386 order
 Evidence X-RAY 1wwa Y Reference
       Region 1wwa Y 278-382 order
       Region 1wwa Y 383-386 disorder
 Evidence X-RAY 1he7 A Reference
       Region 1he7 A 285-388 order
       Region 1he7 A 389-392 disorder
       Region 1he7 A 393-398 order
       Region 1he7 A 399-413 disorder
Seq 282-382 Hetero tetramer : P01138
 Evidence X-RAY 1www Y Reference
       Region 1www Y 282-382 order
 Evidence X-RAY 1www X Reference
       Region 1www X 282-382 order
Seq 410-447 Homo dimer :
 Evidence NMR 2n90 B Reference
       Region 2n90 B 410-447 order
       Region 2n90 B 410-413 high_rmsd
       Region 2n90 B 443-447 high_rmsd
 Evidence NMR 2n90 A Reference
       Region 2n90 A 410-447 order
       Region 2n90 A 410-413 high_rmsd
       Region 2n90 A 443-447 high_rmsd
Seq 473-796 Monomer :
 Evidence X-RAY 4f0i A Reference
       Region 4f0i A 498-500 disorder
       Region 4f0i A 501-534 order
       Region 4f0i A 535-536 disorder
       Region 4f0i A 537-547 order
       Region 4f0i A 548-551 disorder
       Region 4f0i A 552-790 order
       Region 4f0i A 791-796 disorder
 Evidence X-RAY 4f0i B Reference
       Region 4f0i B 498-500 disorder
       Region 4f0i B 501-794 order
       Region 4f0i B 795-796 disorder
 Evidence X-RAY 4gt5 A Reference
       Region 4gt5 A 498-534 order
       Region 4gt5 A 535-536 disorder
       Region 4gt5 A 537-548 order
       Region 4gt5 A 549-549 disorder
       Region 4gt5 A 550-610 order
       Region 4gt5 A 611-613 disorder
       Region 4gt5 A 614-793 order
       Region 4gt5 A 794-796 disorder
 Evidence X-RAY 5h3q A Reference
       Region 5h3q A 473-483 disorder
       Region 5h3q A 484-531 order
       Region 5h3q A 532-537 disorder
       Region 5h3q A 538-548 order
       Region 5h3q A 549-552 disorder
       Region 5h3q A 553-795 order
       Region 5h3q A 796-796 disorder
 Evidence X-RAY 5i8a A Reference
       Region 5i8a A 498-500 disorder
       Region 5i8a A 501-518 order
       Region 5i8a A 519-521 disorder
       Region 5i8a A 522-531 order
       Region 5i8a A 532-537 disorder
       Region 5i8a A 538-547 order
       Region 5i8a A 548-555 disorder
       Region 5i8a A 556-670 order
       Region 5i8a A 671-671 disorder
       Region 5i8a A 672-683 order
       Region 5i8a A 684-686 disorder
       Region 5i8a A 687-787 order
 Evidence X-RAY 5jfs A Reference
       Region 5jfs A 502-606 order
       Region 5jfs A 607-616 disorder
       Region 5jfs A 617-670 order
       Region 5jfs A 671-688 disorder
       Region 5jfs A 689-793 order
       Region 5jfs A 794-796 disorder
 Evidence X-RAY 5jfv A Reference
       Region 5jfv A 502-606 order
       Region 5jfv A 607-616 disorder
       Region 5jfv A 617-670 order
       Region 5jfv A 671-688 disorder
       Region 5jfv A 689-793 order
       Region 5jfv A 794-796 disorder
 Evidence X-RAY 5jfw A Reference
       Region 5jfw A 502-606 order
       Region 5jfw A 607-616 disorder
       Region 5jfw A 617-670 order
       Region 5jfw A 671-688 disorder
       Region 5jfw A 689-793 order
       Region 5jfw A 794-796 disorder
 Evidence X-RAY 5jfx A Reference
       Region 5jfx A 502-606 order
       Region 5jfx A 607-616 disorder
       Region 5jfx A 617-670 order
       Region 5jfx A 671-688 disorder
       Region 5jfx A 689-793 order
       Region 5jfx A 794-796 disorder
 Evidence X-RAY 5kmi A Reference
       Region 5kmi A 474-485 disorder
       Region 5kmi A 486-495 order
       Region 5kmi A 496-500 disorder
       Region 5kmi A 501-547 order
       Region 5kmi A 548-550 disorder
       Region 5kmi A 551-610 order
       Region 5kmi A 611-613 disorder
       Region 5kmi A 614-796 order
 Evidence X-RAY 5kmj A Reference
       Region 5kmj A 474-485 disorder
       Region 5kmj A 486-495 order
       Region 5kmj A 496-499 disorder
       Region 5kmj A 500-548 order
       Region 5kmj A 549-550 disorder
       Region 5kmj A 551-609 order
       Region 5kmj A 610-613 disorder
       Region 5kmj A 614-795 order
       Region 5kmj A 796-796 disorder
 Evidence X-RAY 5kmk A Reference
       Region 5kmk A 474-483 disorder
       Region 5kmk A 484-493 order
       Region 5kmk A 494-499 disorder
       Region 5kmk A 500-547 order
       Region 5kmk A 548-550 disorder
       Region 5kmk A 551-610 order
       Region 5kmk A 611-612 disorder
       Region 5kmk A 613-796 order
 Evidence X-RAY 5kml A Reference
       Region 5kml A 474-479 order
       Region 5kml A 480-498 disorder
       Region 5kml A 499-534 order
       Region 5kml A 535-536 disorder
       Region 5kml A 537-548 order
       Region 5kml A 549-549 disorder
       Region 5kml A 550-608 order
       Region 5kml A 609-613 disorder
       Region 5kml A 614-796 order
 Evidence X-RAY 5kmm A Reference
       Region 5kmm A 474-483 disorder
       Region 5kmm A 484-491 order
       Region 5kmm A 492-499 disorder
       Region 5kmm A 500-547 order
       Region 5kmm A 548-550 disorder
       Region 5kmm A 551-610 order
       Region 5kmm A 611-612 disorder
       Region 5kmm A 613-796 order
 Evidence X-RAY 5kmn A Reference
       Region 5kmn A 474-479 order
       Region 5kmn A 480-498 disorder
       Region 5kmn A 499-534 order
       Region 5kmn A 535-536 disorder
       Region 5kmn A 537-548 order
       Region 5kmn A 549-549 disorder
       Region 5kmn A 550-608 order
       Region 5kmn A 609-613 disorder
       Region 5kmn A 614-796 order
 Evidence X-RAY 5kmo A Reference
       Region 5kmo A 474-499 disorder
       Region 5kmo A 500-548 order
       Region 5kmo A 549-551 disorder
       Region 5kmo A 552-610 order
       Region 5kmo A 611-612 disorder
       Region 5kmo A 613-670 order
       Region 5kmo A 671-672 disorder
       Region 5kmo A 673-796 order
 Evidence X-RAY 5kvt A Reference
       Region 5kvt A 501-532 order
       Region 5kvt A 533-536 disorder
       Region 5kvt A 537-787 order
 Evidence X-RAY 4pmm A Reference
       Region 4pmm A 501-533 order
       Region 4pmm A 534-536 disorder
       Region 4pmm A 537-548 order
       Region 4pmm A 549-551 disorder
       Region 4pmm A 552-787 order
 Evidence X-RAY 4pmp A Reference
       Region 4pmp A 501-533 order
       Region 4pmp A 534-537 disorder
       Region 4pmp A 538-547 order
       Region 4pmp A 548-551 disorder
       Region 4pmp A 552-673 order
       Region 4pmp A 674-674 disorder
       Region 4pmp A 675-684 order
       Region 4pmp A 685-686 disorder
       Region 4pmp A 687-787 order
 Evidence X-RAY 4pms A Reference
       Region 4pms A 501-533 order
       Region 4pms A 534-536 disorder
       Region 4pms A 537-548 order
       Region 4pms A 549-551 disorder
       Region 4pms A 552-683 order
       Region 4pms A 684-685 disorder
       Region 4pms A 686-787 order
 Evidence X-RAY 4pmt A Reference
       Region 4pmt A 501-532 order
       Region 4pmt A 533-536 disorder
       Region 4pmt A 537-546 order
       Region 4pmt A 547-555 disorder
       Region 4pmt A 556-669 order
       Region 4pmt A 670-671 disorder
       Region 4pmt A 672-683 order
       Region 4pmt A 684-686 disorder
       Region 4pmt A 687-787 order
 Evidence X-RAY 5wr7 A Reference
       Region 5wr7 A 489-684 order
       Region 5wr7 A 685-686 disorder
       Region 5wr7 A 687-792 order
 Evidence X-RAY 4yne A Reference
       Region 4yne A 502-534 order
       Region 4yne A 535-536 disorder
       Region 4yne A 537-548 order
       Region 4yne A 549-553 disorder
       Region 4yne A 554-671 order
       Region 4yne A 672-676 disorder
       Region 4yne A 677-682 order
       Region 4yne A 683-686 disorder
       Region 4yne A 687-793 order
       Region 4yne A 794-796 disorder
 Evidence X-RAY 4yps A Reference
       Region 4yps A 502-518 order
       Region 4yps A 519-521 disorder
       Region 4yps A 522-533 order
       Region 4yps A 534-536 disorder
       Region 4yps A 537-546 order
       Region 4yps A 547-549 disorder
       Region 4yps A 550-668 order
       Region 4yps A 669-670 disorder
       Region 4yps A 671-683 order
       Region 4yps A 684-686 disorder
       Region 4yps A 687-790 order
       Region 4yps A 791-796 disorder
Seq 473-796 Homo dodecamer :
 Evidence X-RAY 4aoj C Reference
       Region 4aoj C 473-499 disorder
       Region 4aoj C 500-534 order
       Region 4aoj C 535-535 disorder
       Region 4aoj C 536-607 order
       Region 4aoj C 608-619 disorder
       Region 4aoj C 620-671 order
       Region 4aoj C 672-687 disorder
       Region 4aoj C 688-789 order
       Region 4aoj C 790-796 disorder
 Evidence X-RAY 4aoj B Reference
       Region 4aoj B 473-499 disorder
       Region 4aoj B 500-534 order
       Region 4aoj B 535-537 disorder
       Region 4aoj B 538-607 order
       Region 4aoj B 608-619 disorder
       Region 4aoj B 620-669 order
       Region 4aoj B 670-688 disorder
       Region 4aoj B 689-791 order
       Region 4aoj B 792-796 disorder
 Evidence X-RAY 4aoj A Reference
       Region 4aoj A 473-499 disorder
       Region 4aoj A 500-534 order
       Region 4aoj A 535-537 disorder
       Region 4aoj A 538-607 order
       Region 4aoj A 608-618 disorder
       Region 4aoj A 619-670 order
       Region 4aoj A 671-686 disorder
       Region 4aoj A 687-789 order
       Region 4aoj A 790-796 disorder
Seq 489-500 Hetero dimer : IID00511Complex
 Evidence NMR 1shc B Reference
       Region 1shc B 489-500 order
SeqProS verified 489-499 Hetero dimer : IID00511Complex
       Region 1shc B 489-500 order
       Region 4aoj A 473-499 disorder
Seqphosphorylation
    791-791 Phosphotyrosine; by autocatalysis
    681-681 Phosphotyrosine; by autocatalysis
    680-680 Phosphotyrosine; by autocatalysis
    676-676 Phosphotyrosine; by autocatalysis
    496-496 Phosphotyrosine; by autocatalysis
 
Prediction
NeProc
Disorder 1-26,401-416,440-491
Order 27-400,417-439,492-613,619-796
ProS 1-26,401-416,440-477,485-491
AlphaFold
Disorder 1-38,61-61,63-66,188-189,296-297,335-339,382-418,441-500,519-521,548-550,552-553,610-615,668-675,683-687,792-796
Order 39-60,62-62,67-187,190-295,298-334,340-381,419-440,501-518,522-547,551-551,554-609,616-667,676-682,688-791
Pfam Hmmer
PF07714 510-781 1e-147
SEG 29-42 ,82-96 ,617-631
Function
Function in SwissProt
Isoform TrkA-III
Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.