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IID00537
 UniprotP08575
ProteinReceptor-type tyrosine-protein phosphatase C
GenePTPRC
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1306
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 225-394 Monomer :
 Evidence X-RAY 5fn7 A Reference
       Region 5fn7 A 225-390 order
       Region 5fn7 A 391-394 disorder
 Evidence X-RAY 5fn7 B Reference
       Region 5fn7 B 225-389 order
       Region 5fn7 B 390-394 disorder
Seq 225-573 Monomer :
 Evidence X-RAY 5fmv A Reference
       Region 5fmv A 225-225 disorder
       Region 5fmv A 226-573 order
 Evidence X-RAY 5fmv B Reference
       Region 5fmv B 225-227 disorder
       Region 5fmv B 228-573 order
 Evidence X-RAY 5fn6 A Reference
       Region 5fn6 A 225-226 disorder
       Region 5fn6 A 227-261 order
       Region 5fn6 A 262-264 disorder
       Region 5fn6 A 265-481 order
Seq 624-1233 Hetero dimer : IID90016Complex
 Evidence X-RAY 1ygu B Reference
       Region 1ygu B 624-624 disorder
       Region 1ygu B 625-990 order
       Region 1ygu B 991-1014 disorder
       Region 1ygu B 1015-1230 order
       Region 1ygu B 1231-1233 disorder
 Evidence X-RAY 1ygu A Reference
       Region 1ygu A 624-988 order
       Region 1ygu A 989-1014 disorder
       Region 1ygu A 1015-1152 order
       Region 1ygu A 1153-1162 disorder
       Region 1ygu A 1163-1230 order
       Region 1ygu A 1231-1233 disorder
Seq 624-1233 Hetero dimer : IID00544Complex
 Evidence X-RAY 1ygr B Reference
       Region 1ygr B 624-624 disorder
       Region 1ygr B 625-990 order
       Region 1ygr B 991-1014 disorder
       Region 1ygr B 1015-1149 order
       Region 1ygr B 1150-1160 disorder
       Region 1ygr B 1161-1233 order
 Evidence X-RAY 1ygr A Reference
       Region 1ygr A 624-988 order
       Region 1ygr A 989-1014 disorder
       Region 1ygr A 1015-1152 order
       Region 1ygr A 1153-1159 disorder
       Region 1ygr A 1160-1230 order
       Region 1ygr A 1231-1233 disorder
Seqphosphorylation
    1299-1299 Phosphoserine
    1009-1009 Phosphoserine
    1005-1005 Phosphoserine
    1004-1004 Phosphoserine
    1001-1001 Phosphoserine
    997-997 Phosphoserine
    994-994 Phosphoserine
    683-683 Phosphotyrosine
    975-975 Phosphoserine
 
Prediction
NeProc
Disorder 31-227,609-618,995-1010,1251-1306
Order 1-26,228-608,619-990,1011-1250
ProS 52-57,64-79,135-195,215-220,1251-1264
AlphaFold
Disorder 1-225,261-263,604-621,821-821,844-844,989-1014,1128-1128,1150-1163,1232-1306
Order 226-260,264-603,622-820,822-843,845-988,1015-1127,1129-1149,1164-1231
Pfam Hmmer
PF00041 392-472 3.9e-05
PF00041 485-566 0.00026
PF00102 677-911 1.1e-126
PF00102 968-1227 1.1e-106
SEG 164-182 ,214-227 ,992-1015
Function
Function in SwissProt
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.
Biological Process
See also
Diagram with PDB data
LCKSH3-SH2 DOMAIN FRAGMENT OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 10 RESIDUE SYNTHETIC PHOSPHOTYROSYL PEPTIDE TEGQPYQPQPA
FYNFyn SH2 domain in complex with the natural inhibitory phosphotyrosine peptide