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IID00540  Cystic fibrosis transmembrane conductance regulator (Homo sapiens) P13569
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
1480
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 5-20 Hetero trimer : P21333
 Evidence X-RAY 3isw C Reference
       Region 3isw C 5-20 order
Seq 375-678 Monomer :
 Evidence X-RAY 2bbo A Reference
       Region 2bbo A 389-404 order
       Region 2bbo A 405-435 disorder
       Region 2bbo A 436-645 order
       Region 2bbo A 646-648 disorder
       Region 2bbo A 649-676 order
       Region 2bbo A 677-678 disorder
 Evidence X-RAY 2bbs A Reference
       Region 2bbs A 389-413 order
       Region 2bbs A 414-436 disorder
       Region 2bbs A 437-541 order
       Region 2bbs A 542-545 disorder
       Region 2bbs A 546-645 order
       Region 2bbs A 646-648 disorder
       Region 2bbs A 649-671 order
       Region 2bbs A 672-677 disorder
 Evidence X-RAY 2bbs B Reference
       Region 2bbs B 389-401 order
       Region 2bbs B 402-439 disorder
       Region 2bbs B 440-542 order
       Region 2bbs B 543-544 disorder
       Region 2bbs B 545-637 order
       Region 2bbs B 638-647 disorder
       Region 2bbs B 648-670 order
       Region 2bbs B 671-677 disorder
 Evidence X-RAY 2bbt A Reference
       Region 2bbt A 389-389 disorder
       Region 2bbt A 390-413 order
       Region 2bbt A 414-436 disorder
       Region 2bbt A 437-542 order
       Region 2bbt A 543-544 disorder
       Region 2bbt A 545-642 order
       Region 2bbt A 643-647 disorder
       Region 2bbt A 648-669 order
       Region 2bbt A 670-678 disorder
 Evidence X-RAY 2bbt B Reference
       Region 2bbt B 389-418 order
       Region 2bbt B 419-437 disorder
       Region 2bbt B 438-541 order
       Region 2bbt B 542-544 disorder
       Region 2bbt B 545-645 order
       Region 2bbt B 646-647 disorder
       Region 2bbt B 648-671 order
       Region 2bbt B 672-678 disorder
 Evidence X-RAY 2pze A Reference
       Region 2pze A 387-636 order
       Region 2pze A 637-638 disorder
       Region 2pze A 639-645 order
       Region 2pze A 646-646 disorder
 Evidence X-RAY 2pze B Reference
       Region 2pze B 387-388 disorder
       Region 2pze B 389-639 order
       Region 2pze B 640-646 disorder
 Evidence X-RAY 2pzf A Reference
       Region 2pzf A 387-401 order
       Region 2pzf A 402-403 disorder
       Region 2pzf A 404-636 order
       Region 2pzf A 637-638 disorder
       Region 2pzf A 639-646 order
 Evidence X-RAY 2pzf B Reference
       Region 2pzf B 387-387 disorder
       Region 2pzf B 388-636 order
       Region 2pzf B 637-646 disorder
 Evidence X-RAY 2pzg A Reference
       Region 2pzg A 375-389 disorder
       Region 2pzg A 390-635 order
       Region 2pzg A 636-637 disorder
       Region 2pzg A 638-646 order
 Evidence X-RAY 2pzg B Reference
       Region 2pzg B 375-386 disorder
       Region 2pzg B 387-542 order
       Region 2pzg B 543-545 disorder
       Region 2pzg B 546-636 order
       Region 2pzg B 637-646 disorder
 Evidence X-RAY 4wz6 A Reference
       Region 4wz6 A 389-414 order
       Region 4wz6 A 415-433 disorder
       Region 4wz6 A 434-541 order
       Region 4wz6 A 542-544 disorder
       Region 4wz6 A 545-645 order
       Region 4wz6 A 646-648 disorder
       Region 4wz6 A 649-672 order
       Region 4wz6 A 673-678 disorder
 Evidence X-RAY 1xmj A Reference
       Region 1xmj A 389-390 disorder
       Region 1xmj A 391-402 order
       Region 1xmj A 403-437 disorder
       Region 1xmj A 438-645 order
       Region 1xmj A 646-648 disorder
       Region 1xmj A 649-675 order
       Region 1xmj A 676-677 disorder
Seq 389-678 Homo pentamer :
 Evidence X-RAY 1xmi A Reference
       Region 1xmi A 389-411 order
       Region 1xmi A 412-428 disorder
       Region 1xmi A 429-671 order
       Region 1xmi A 672-678 disorder
 Evidence X-RAY 1xmi B Reference
       Region 1xmi B 389-413 order
       Region 1xmi B 414-428 disorder
       Region 1xmi B 429-532 order
       Region 1xmi B 533-538 disorder
       Region 1xmi B 539-541 order
       Region 1xmi B 542-546 disorder
       Region 1xmi B 547-671 order
       Region 1xmi B 672-678 disorder
 Evidence X-RAY 1xmi C Reference
       Region 1xmi C 389-415 order
       Region 1xmi C 416-428 disorder
       Region 1xmi C 429-671 order
       Region 1xmi C 672-678 disorder
 Evidence X-RAY 1xmi D Reference
       Region 1xmi D 389-410 order
       Region 1xmi D 411-425 disorder
       Region 1xmi D 426-543 order
       Region 1xmi D 544-545 disorder
       Region 1xmi D 546-672 order
       Region 1xmi D 673-678 disorder
 Evidence X-RAY 1xmi E Reference
       Region 1xmi E 389-411 order
       Region 1xmi E 412-428 disorder
       Region 1xmi E 429-671 order
       Region 1xmi E 672-678 disorder
Seq 747-774 Hetero trimer : IID00061Complex
 Evidence X-RAY 5d2d C Reference
       Region 5d2d C 747-750 disorder
       Region 5d2d C 751-758 order
       Region 5d2d C 759-763 disorder
       Region 5d2d C 764-774 order
 Evidence X-RAY 5d3f C Reference
       Region 5d3f C 747-749 disorder
       Region 5d3f C 750-756 order
       Region 5d3f C 757-763 disorder
       Region 5d3f C 764-774 order
Seq 762-801 Hetero trimer : P61981
 Evidence X-RAY 5d3e C Reference
       Region 5d3e C 762-765 disorder
       Region 5d3e C 766-770 order
       Region 5d3e C 771-792 disorder
       Region 5d3e C 793-798 order
       Region 5d3e C 799-801 disorder
 Evidence X-RAY 5d3e G Reference
       Region 5d3e G 762-766 disorder
       Region 5d3e G 767-771 order
       Region 5d3e G 772-792 disorder
       Region 5d3e G 793-798 order
       Region 5d3e G 799-801 disorder
Seq 762-801 Hetero trimer : P61981
 Evidence X-RAY 5d3e K Reference
       Region 5d3e K 762-766 disorder
       Region 5d3e K 767-770 order
       Region 5d3e K 771-801 disorder
Seq 1193-1427 Hetero dimer : P68187
 Evidence X-RAY 3gd7 C Reference
       Region 3gd7 C 1193-1203 disorder
       Region 3gd7 C 1204-1427 order
Seq 1193-1427 Hetero dimer : P68187
 Evidence X-RAY 3gd7 D Reference
       Region 3gd7 D 1193-1201 disorder
       Region 3gd7 D 1202-1427 order
Seq 1193-1427 Hetero dimer : P68187
 Evidence X-RAY 3gd7 A Reference
       Region 3gd7 A 1193-1201 disorder
       Region 3gd7 A 1202-1427 order
Seq 1193-1427 Hetero dimer : P68187
 Evidence X-RAY 3gd7 B Reference
       Region 3gd7 B 1193-1202 disorder
       Region 3gd7 B 1203-1427 order
Seq 1473-1480 Hetero dimer : IID00520Complex
 Evidence NMR 2lob B Reference
       Region 2lob B 1473-1480 order
SeqProS predicted 751-758,764-774 The unbound state of this region is predicted to be disordered by DICHOT, FoldIndex and MobiDB Hetero trimer : IID00061Complex
       Region 5d3f C 750-756 order
       Region 5d2d C 751-758 order
       Region 5d3f C 764-774 order
       Region 5d2d C 764-774 order
SeqProS predicted 766-770 The unbound state of this region is predicted to be disordered by DICHOT, FoldIndex and MobiDB Hetero trimer : P61981
       Region 5d3e K 767-770 order
SeqProS predicted 766-770,793-798 The unbound state of this region is predicted to be disordered by DICHOT, FoldIndex and MobiDB Hetero trimer : P61981
       Region 5d3e C 766-770 order
       Region 5d3e G 767-771 order
       Region 5d3e C 793-798 order
       Region 5d3e G 793-798 order
Seqphosphorylation
    549-549 Phosphoserine
    660-660 Phosphoserine; by PKA
    670-670 Phosphoserine; by PKA
    686-686 Phosphoserine; by PKC
    700-700 Phosphoserine; by PKA
    712-712 Phosphoserine; by PKA
    717-717 Phosphothreonine
    737-737 Phosphoserine; by PKA
    753-753 Phosphoserine; by PKA
    768-768 Phosphoserine; by PKA
    790-790 Phosphoserine; by PKC
    795-795 Phosphoserine; by PKA
    813-813 Phosphoserine; by PKA
    1444-1444 Phosphoserine
    1456-1456 Phosphoserine
 
Prediction
DICHOT
Disorder 58-67,301-303,380-389,671-845,1165-1201,1431-1480
Known Domain 68-300,304-379,390-670,846-1164,1202-1430
Cryptic Domain 1-57
SCOPe RPS-Blast
     3b60A2 79-328 7e-12 f.37.1.1 Multidrug resistance ABC transporter M...
     2pzeA1 387-645 3e-91 c.37.1.12 ABC transporter involved in vitamin ...
     3b60A2 846-1172 2e-11 f.37.1.1 Multidrug resistance ABC transporter...
     5x7kA 1208-1440 6e-45 c.37.1.0 automated matches
SCOP Hmmer
     2hydA2 65-376 4.1e-33 f.37.1.1 Multidrug resist...
     1w36D1 375-478 0.00072 c.37.1.19 ATP-dependent ...
     3b60A1 432-640 2.1e-52 c.37.1.12 ABC transporte...
     2hydA2 850-1175 6.7e-45 f.37.1.1 Multidrug resi...
     3b60A1 1203-1440 2.6e-59 c.37.1.12 ABC transpor...
Pfam RPS-Blast
     PF00005 441-575 1e-13 ABC transporter
     PF14396 639-849 e-106 Cystic fibrosis TM conducta...
     PF00005 1227-1374 4e-16 ABC transporter
Pfam Hmmer
    PF00664 82-350 1.4e-45 ABC transporter transmembra...
    PF00005 441-575 1.9e-26 ABC transporter
    PF14396 639-849 3.5e-99 Cystic fibrosis TM conduct...
    PF00664 862-1147 2e-53 ABC transporter transmembra...
    PF00005 1227-1374 1.1e-36 ABC transporter