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IID00541
UniprotP15923
ProteinTranscription factor E2-alpha
GeneTCF3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
654
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-37
 Evidence NMR Reference
       Region 1-37 disorder
Seq 1-37 Hetero dimer : IID00070Complex
 Evidence NMR 2mh0 A Reference
       Region 2mh0 A 1-37 order
       Region 2mh0 A 1-5 high_rmsd
       Region 2mh0 A 33-37 high_rmsd
Seq 538-616 Hetero tetramer : IID00268Complex,IID00543Complex
 Evidence X-RAY 2ypa B Isoform E47 (P15923-2) Reference
       Region 2ypa B 538-541 disorder
       Region 2ypa B 542-614 order
       Region 2ypa B 615-616 disorder
Seq 538-616 Hetero dimer : IID00543Complex
 Evidence X-RAY 2ypb B Isoform E47 (P15923-2) Reference
       Region 2ypb B 538-538 disorder
       Region 2ypb B 539-612 order
       Region 2ypb B 613-616 disorder
Seq 561-612 Hetero dimer : IID50360Complex
 Evidence X-RAY 6mgn A Isoform E47 (P15923-2) Reference
       Region 6mgn A 561-612 order
Seq 563-613 Hetero tetramer : IID50243Complex
 Evidence X-RAY 3u5v A Isoform E47 (P15923-2) Reference
       Region 3u5v A 563-613 order
SeqProS verified 6-32 The residues with high_rmsd are excluded from the ProS. Hetero dimer : IID00070Complex
       Region 2mh0 A 1-37 order
       Region 1-37 disorder
Seqphosphorylation
    531-531 Phosphothreonine
    139-139 Phosphoserine
    529-529 Phosphoserine
    379-379 Phosphoserine
    359-359 Phosphoserine
    355-355 Phosphothreonine
    134-134 Phosphoserine
 
Prediction
NeProc
Disorder 1-553,620-654
Order 554-619
ProS 7-38,72-84,92-116,133-139,173-201,207-218,225-228,337-342,380-385,392-407,415-421,477-482,498-502,520-531,537-553,646-654
AlphaFold
Disorder 1-14,29-332,335-335,337-387,389-390,409-538,612-612,614-649,651-654
Order 15-28,333-334,336-336,388-388,391-408,539-611,613-613,650-650
Pfam Hmmer
PF00010 550-603 1.6e-12
SEG 55-68 ,80-94 ,147-160 ,235-268 ,285-299 ,341-354 ,496-506 ,530-541
Function
Function in SwissProt
Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity.
Biological Process
Diagram with PDB data
TCF3/EP300Solution NMR structure of the p300 Taz2:ETAD1 complex