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IID00551
 UniprotP41208
ProteinCentrin-2
GeneCETN2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
172
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-98 Monomer :
 Evidence NMR 1zmz A Reference
       Region 1zmz A 1-98 order
       Region 1zmz A 1-23 high_rmsd
Seq 1-172 Hetero dimer : IID00164Complex
 Evidence X-RAY 2ggm A Reference
       Region 2ggm A 1-23 disorder
       Region 2ggm A 24-172 order
 Evidence X-RAY 2ggm B Reference
       Region 2ggm B 1-24 disorder
       Region 2ggm B 25-168 order
       Region 2ggm B 169-172 disorder
Seq 26-168 Hetero tetramer : IID00164Complex
 Evidence X-RAY 2obh B Reference
       Region 2obh B 26-168 order
 Evidence X-RAY 2obh A Reference
       Region 2obh A 26-168 order
Seqdisorder 84-172
 Evidence CD Reference
       Region 84-172 disorder
Seq 84-172 Monomer :
 Evidence NMR 1m39 A Reference
       Region 1m39 A 84-85 disorder
       Region 1m39 A 86-165 order
       Region 1m39 A 97-98 high_rmsd
       Region 1m39 A 166-172 disorder
Seq 94-172 Hetero dimer : IID00164Complex
 Evidence NMR 2a4j A Reference
       Region 2a4j A 94-99 disorder
       Region 2a4j A 94-98 high_rmsd
       Region 2a4j A 100-167 order
       Region 2a4j A 168-172 disorder
       Region 2a4j A 171-172 high_rmsd
Seq 94-172 Hetero dimer : A8K8P3
 Evidence NMR 2k2i A Reference
       Region 2k2i A 94-99 disorder
       Region 2k2i A 94-100 high_rmsd
       Region 2k2i A 100-168 order
       Region 2k2i A 169-172 disorder
       Region 2k2i A 170-172 high_rmsd
SeqProS verified 100-168 Hetero dimer : A8K8P3
       Region 2k2i A 100-168 order
       Region 84-172 disorder
SeqProS verified 100-168 Hetero dimer : IID00164Complex
       Region 2a4j A 100-167 order
       Region 84-172 disorder
Seqphosphorylation
    20-20 Phosphoserine
    26-26 Phosphothreonine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-22
Order 23-172
AlphaFold
Disorder 1-23,170-172
Order 24-169
Pfam Hmmer
PF00036 32-60 6.9e-09
PF00036 68-96 4.4e-05
PF00036 105-133 0.00024
PF00036 141-169 6e-09
SEG 63-79
Function
Function in SwissProt
Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:22307388).
Biological Process
See also
Diagram with PDB data
XPA/ERCC1Solution structure of a ERCC1-XPA heterodimer
XPC/CETN2Solution structure of the C-terminal domain (T94-Y172) of the human centrin 2 in complex with a 17 residues peptide (P1-XPC) from xeroderma pigmentosum group C protein
XPC/GTF2H1Solution structure of the complex between XPC acidic domain and TFIIH p62 PH domain