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IID00568  Mediator of DNA damage checkpoint protein 1 (Homo sapiens) Q14676
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
2089
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-10,19-138 Hetero dimer :
 Evidence X-RAY 3unn A Reference
       Region 3unn A 27-133 order
       Region 3unn A 134-138 disorder
 Evidence X-RAY 3uot A Reference
       Region 3uot A 19-135 order
       Region 3uot A 136-138 disorder
 Evidence X-RAY 3uot B Reference
       Region 3uot B 19-27 disorder
       Region 3uot B 28-134 order
       Region 3uot B 135-138 disorder
 Evidence X-RAY 3unn B Reference
       Region 3unn B 1-8 order
 Evidence X-RAY 3uot D Reference
       Region 3uot D 1-1 disorder
       Region 3uot D 2-9 order
       Region 3uot D 10-10 disorder
 Evidence X-RAY 3uot E Reference
       Region 3uot E 1-1 disorder
       Region 3uot E 2-9 order
       Region 3uot E 10-10 disorder
Seq 26-138 Homo dimer :
 Evidence X-RAY 3umz A Reference
       Region 3umz A 27-28 disorder
       Region 3umz A 29-133 order
       Region 3umz A 134-138 disorder
 Evidence X-RAY 3umz B Reference
       Region 3umz B 27-28 disorder
       Region 3umz B 29-133 order
       Region 3umz B 134-138 disorder
 Evidence X-RAY 3un0 A Reference
       Region 3un0 A 26-134 order
       Region 3un0 A 135-138 disorder
 Evidence X-RAY 3un0 B Reference
       Region 3un0 B 26-26 disorder
       Region 3un0 B 27-133 order
       Region 3un0 B 134-138 disorder
 Evidence X-RAY 3unm A Reference
       Region 3unm A 27-28 disorder
       Region 3unm A 29-101 order
       Region 3unm A 102-104 disorder
       Region 3unm A 105-109 order
       Region 3unm A 110-110 disorder
       Region 3unm A 111-133 order
       Region 3unm A 134-138 disorder
 Evidence X-RAY 3unm B Reference
       Region 3unm B 27-28 disorder
       Region 3unm B 29-134 order
       Region 3unm B 135-138 disorder
Seq 325-336 Hetero trimer : Q92547
 Evidence X-RAY 3ueo F Reference
       Region 3ueo F 325-327 disorder
       Region 3ueo F 328-335 order
       Region 3ueo F 336-336 disorder
 Evidence X-RAY 3ueo E Reference
       Region 3ueo E 325-325 disorder
       Region 3ueo E 326-335 order
       Region 3ueo E 336-336 disorder
Seq 1883-2089 Hetero dimer : IID00027Complex
 Evidence X-RAY 2azm A Reference
       Region 2azm A 1883-1890 disorder
       Region 2azm A 1891-2083 order
       Region 2azm A 2084-2089 disorder
 Evidence X-RAY 2azm B Reference
       Region 2azm B 1883-1890 disorder
       Region 2azm B 1891-2085 order
       Region 2azm B 2086-2089 disorder
Seq 1884-2089 Homo dimer :
 Evidence X-RAY 2etx A Reference
       Region 2etx A 1884-1891 disorder
       Region 2etx A 1892-2085 order
       Region 2etx A 2086-2089 disorder
 Evidence X-RAY 2etx B Reference
       Region 2etx B 1884-1890 disorder
       Region 2etx B 1891-2085 order
       Region 2etx B 2086-2089 disorder
Seq 1891-2089 Monomer :
 Evidence X-RAY 2ado A Reference
       Region 2ado A 1891-1891 disorder
       Region 2ado A 1892-2085 order
       Region 2ado A 2086-2086 disorder
 Evidence X-RAY 2ado B Reference
       Region 2ado B 1891-2085 order
       Region 2ado B 2086-2086 disorder
 Evidence X-RAY 3k05 A This region binds to a peptide. Reference
       Region 3k05 A 1891-2083 order
       Region 3k05 A 2084-2089 disorder
 Evidence X-RAY 3k05 B This region binds to a peptide. Reference
       Region 3k05 B 1891-2089 order
Seqphosphorylation
    4-4 Phosphothreonine; by ATM
    108-108 Phosphoserine
    146-146 Phosphothreonine
    168-168 Phosphoserine
    176-176 Phosphoserine
    299-299 Phosphoserine
    301-301 Phosphothreonine
    329-329 Phosphoserine
    331-331 Phosphothreonine
    372-372 Phosphoserine
    376-376 Phosphoserine
    378-378 Phosphothreonine
    394-394 Phosphoserine
    397-397 Phosphoserine
    402-402 Phosphoserine
    404-404 Phosphothreonine
    411-411 Phosphoserine
    449-449 Phosphothreonine
    453-453 Phosphoserine
    455-455 Phosphothreonine
    485-485 Phosphoserine
    495-495 Phosphoserine
    498-498 Phosphoserine
    504-504 Phosphoserine
    505-505 Phosphoserine
    513-513 Phosphoserine
    523-523 Phosphothreonine
    590-590 Phosphoserine
    780-780 Phosphoserine
    793-793 Phosphoserine
    955-955 Phosphoserine
    998-998 Phosphoserine
    1033-1033 Phosphoserine
    1068-1068 Phosphoserine
    1086-1086 Phosphoserine
    1157-1157 Phosphothreonine
    1198-1198 Phosphothreonine
    1235-1235 Phosphoserine
    1239-1239 Phosphothreonine
    1280-1280 Phosphothreonine
    1302-1302 Phosphothreonine
    1399-1399 Phosphoserine
    1400-1400 Phosphoserine
    1403-1403 Phosphothreonine
    1425-1425 Phosphothreonine
    1466-1466 Phosphothreonine
    1548-1548 Phosphothreonine
    1564-1564 Phosphoserine
    1567-1567 Phosphothreonine
    1589-1589 Phosphothreonine
    1604-1604 Phosphoserine
    1608-1608 Phosphothreonine
    1630-1630 Phosphothreonine
    1664-1664 Phosphothreonine
    1671-1671 Phosphothreonine
    1681-1681 Phosphoserine
    1697-1697 Phosphothreonine
    1702-1702 Phosphoserine
    1711-1711 Phosphoserine
    1775-1775 Phosphoserine
    1800-1800 Phosphothreonine
    1820-1820 Phosphoserine
    1858-1858 Phosphothreonine
Seqacetylation
    812-812 N6-acetyllysine
    1402-1402 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-28,134-1099,1191-1373,1479-1891,2086-2089
Known Domain 29-133,1100-1190,1374-1478,1892-2085
SCOPe RPS-Blast
     2affA 30-110 2e-11 b.26.1.2 Afadin
     1kzyC1 1856-1968 1e-14 c.15.1.4 53BP1
SCOP Hmmer
     1uhtA_ 28-134 7.6e-19 SMAD/FHA domain
     1kzyC1 1897-1987 3.5e-21 c.15.1.4 53BP1
     1jnxX2 1994-2074 1.6e-06 c.15.1.3 Breast cancer...
Pfam RPS-Blast
     PF16697 35-110 4e-09 Inner membrane component of ...
     PF05110 1043-1790 1e-06 AF-4 proto-oncoprotein
     PF16770 1877-1969 4e-20 Regulator of Ty1 transpos...
Pfam Hmmer
    PF00498 55-123 3.2e-14 FHA domain
    PF16770 1883-1968 2.2e-10 Regulator of Ty1 transpo...