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IID00574
 UniprotQ8TF76
ProteinSerine/threonine-protein kinase haspin
GeneHASPIN
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
798
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 452-798 Monomer :
 Evidence X-RAY 2wb8 A Reference
       Region 2wb8 A 452-760 order
       Region 2wb8 A 761-761 disorder
       Region 2wb8 A 762-798 order
 Evidence X-RAY 2vuw A Reference
       Region 2vuw A 465-469 disorder
       Region 2vuw A 470-798 order
 Evidence X-RAY 4qtc A Reference
       Region 4qtc A 465-468 disorder
       Region 4qtc A 469-798 order
 Evidence X-RAY 3iq7 A Reference
       Region 3iq7 A 465-470 disorder
       Region 3iq7 A 471-798 order
 Evidence X-RAY 3fmd A Reference
       Region 3fmd A 470-798 order
 Evidence X-RAY 3f2n A Reference
       Region 3f2n A 465-470 disorder
       Region 3f2n A 471-798 order
 Evidence X-RAY 3e7v A Reference
       Region 3e7v A 471-798 order
 Evidence X-RAY 3dlz A Reference
       Region 3dlz A 465-469 disorder
       Region 3dlz A 470-798 order
Seq 465-798 Hetero dimer : IID00088Complex
 Evidence X-RAY 4ouc A Reference
       Region 4ouc A 465-469 disorder
       Region 4ouc A 470-798 order
Seq 465-798 Hetero dimer :
 Evidence X-RAY 5htb A Reference
       Region 5htb A 465-470 disorder
       Region 5htb A 471-798 order
Seq 465-798 Hetero dimer :
 Evidence X-RAY 5htc A Reference
       Region 5htc A 465-470 disorder
       Region 5htc A 471-798 order
Seqphosphorylation
    58-58 Phosphoserine
    93-93 Phosphoserine; by AURKB
    97-97 Phosphothreonine
    143-143 Phosphoserine; by AURKB
    147-147 Phosphoserine
 
Prediction
NeProc
Disorder 1-453
Order 454-798
ProS 7-23,31-45,68-74,123-165,184-189,207-210,239-283,293-300,306-313,320-332,347-354,363-401,411-424,433-439,448-453
AlphaFold
Disorder 1-393,399-400,403-455,495-495
Order 394-398,401-402,456-494,496-798
Pfam Hmmer
PF07714 484-774 8.9e-05
SEG 56-88 ,407-418 ,434-445
Function
Function in SwissProt
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.
Biological Process
See also
Diagram with PDB data
H3C1/YWHAZMolecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3