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IID00576
 UniprotQ96EP0
ProteinE3 ubiquitin-protein ligase RNF31
GeneRNF31
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1072
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-179 Hetero dimer : Q96BN8
 Evidence X-RAY 4p0b A Reference
       Region 4p0b A 1-4 disorder
       Region 4p0b A 5-127 order
       Region 4p0b A 128-131 disorder
       Region 4p0b A 132-177 order
       Region 4p0b A 178-179 disorder
 Evidence X-RAY 4p0b C Reference
       Region 4p0b C 1-4 disorder
       Region 4p0b C 5-62 order
       Region 4p0b C 63-65 disorder
       Region 4p0b C 66-128 order
       Region 4p0b C 129-130 disorder
       Region 4p0b C 131-177 order
       Region 4p0b C 178-179 disorder
Seq 1-179 Hetero dimer : IID00201Complex
 Evidence X-RAY 4p0a A Reference
       Region 4p0a A 1-3 disorder
       Region 4p0a A 4-177 order
       Region 4p0a A 178-179 disorder
 Evidence X-RAY 4p0a C Reference
       Region 4p0a C 1-2 disorder
       Region 4p0a C 3-61 order
       Region 4p0a C 62-64 disorder
       Region 4p0a C 65-127 order
       Region 4p0a C 128-129 disorder
       Region 4p0a C 130-175 order
       Region 4p0a C 176-179 disorder
Seq 1-180 Homo dimer :
 Evidence X-RAY 4juy A Reference
       Region 4juy A 1-179 order
       Region 4juy A 180-180 disorder
 Evidence X-RAY 4juy B Reference
       Region 4juy B 1-179 order
       Region 4juy B 180-180 disorder
Seq 1-184 Monomer :
 Evidence X-RAY 4oyj A Reference
       Region 4oyj A 1-1 disorder
       Region 4oyj A 2-183 order
       Region 4oyj A 184-184 disorder
 Evidence X-RAY 4oyj J Reference
       Region 4oyj J 1-4 disorder
       Region 4oyj J 5-183 order
       Region 4oyj J 184-184 disorder
 Evidence X-RAY 4oyj K Reference
       Region 4oyj K 1-4 disorder
       Region 4oyj K 5-182 order
       Region 4oyj K 183-184 disorder
 Evidence X-RAY 4oyj L Reference
       Region 4oyj L 1-9 disorder
       Region 4oyj L 10-28 order
       Region 4oyj L 29-33 disorder
       Region 4oyj L 34-183 order
       Region 4oyj L 184-184 disorder
 Evidence X-RAY 4oyj M Reference
       Region 4oyj M 1-4 disorder
       Region 4oyj M 5-183 order
       Region 4oyj M 184-184 disorder
 Evidence X-RAY 4oyj B Reference
       Region 4oyj B 1-1 disorder
       Region 4oyj B 2-183 order
       Region 4oyj B 184-184 disorder
 Evidence X-RAY 4oyj C Reference
       Region 4oyj C 1-3 disorder
       Region 4oyj C 4-183 order
       Region 4oyj C 184-184 disorder
 Evidence X-RAY 4oyj D Reference
       Region 4oyj D 1-182 order
       Region 4oyj D 183-184 disorder
 Evidence X-RAY 4oyj E Reference
       Region 4oyj E 1-183 order
       Region 4oyj E 184-184 disorder
 Evidence X-RAY 4oyj F Reference
       Region 4oyj F 1-3 disorder
       Region 4oyj F 4-183 order
       Region 4oyj F 184-184 disorder
 Evidence X-RAY 4oyj G Reference
       Region 4oyj G 1-183 order
       Region 4oyj G 184-184 disorder
 Evidence X-RAY 4oyj H Reference
       Region 4oyj H 1-4 disorder
       Region 4oyj H 5-182 order
       Region 4oyj H 183-184 disorder
 Evidence X-RAY 4oyj I Reference
       Region 4oyj I 1-4 disorder
       Region 4oyj I 5-182 order
       Region 4oyj I 183-184 disorder
 Evidence X-RAY 4p09 A Reference
       Region 4p09 A 1-1 disorder
       Region 4p09 A 2-178 order
       Region 4p09 A 179-179 disorder
Seq 3-179 Hetero tetramer : Q96BN8
 Evidence X-RAY 4oyk B Reference
       Region 4oyk B 3-5 disorder
       Region 4oyk B 6-178 order
       Region 4oyk B 179-179 disorder
 Evidence X-RAY 4oyk A Reference
       Region 4oyk A 3-6 disorder
       Region 4oyk A 7-179 order
Seq 5-176 Hetero dimer : Q9UM82
 Evidence X-RAY 5ljn A Reference
       Region 5ljn A 5-176 order
 Evidence X-RAY 5ljn B Reference
       Region 5ljn B 5-164 order
       Region 5ljn B 165-176 disorder
Seq 350-379 Hetero trimer : O88522
 Evidence X-RAY 4owf G Reference
       Region 4owf G 350-350 disorder
       Region 4owf G 351-379 order
Seq 480-636 Hetero dimer : Q9BYM8
 Evidence X-RAY 4dbg B Reference
       Region 4dbg B 480-481 disorder
       Region 4dbg B 482-627 order
       Region 4dbg B 628-636 disorder
Seq 480-639 Hetero dimer : Q9H0F6
 Evidence X-RAY 5x0w A Reference
       Region 5x0w A 480-546 order
       Region 5x0w A 547-547 disorder
       Region 5x0w A 548-587 order
       Region 5x0w A 588-593 disorder
       Region 5x0w A 594-615 order
       Region 5x0w A 616-639 disorder
 Evidence X-RAY 5x0w C Reference
       Region 5x0w C 480-590 order
       Region 5x0w C 591-594 disorder
       Region 5x0w C 595-613 order
       Region 5x0w C 614-639 disorder
 Evidence X-RAY 5x0w E Reference
       Region 5x0w E 480-588 order
       Region 5x0w E 589-593 disorder
       Region 5x0w E 594-626 order
       Region 5x0w E 627-639 disorder
 Evidence X-RAY 5x0w G Reference
       Region 5x0w G 480-480 disorder
       Region 5x0w G 481-516 order
       Region 5x0w G 517-518 disorder
       Region 5x0w G 519-622 order
       Region 5x0w G 623-639 disorder
Seq 696-1072 Hetero nonamer : P0CG47,P62837
 Evidence X-RAY 5edv B Reference
       Region 5edv B 696-698 disorder
       Region 5edv B 699-754 order
       Region 5edv B 755-759 disorder
       Region 5edv B 760-957 order
       Region 5edv B 958-966 disorder
       Region 5edv B 967-1015 order
       Region 5edv B 1016-1018 disorder
       Region 5edv B 1019-1035 order
       Region 5edv B 1036-1053 disorder
       Region 5edv B 1054-1066 order
       Region 5edv B 1067-1072 disorder
 Evidence X-RAY 5edv A Reference
       Region 5edv A 696-698 disorder
       Region 5edv A 699-707 order
       Region 5edv A 708-710 disorder
       Region 5edv A 711-948 order
       Region 5edv A 949-968 disorder
       Region 5edv A 969-991 order
       Region 5edv A 992-995 disorder
       Region 5edv A 996-1011 order
       Region 5edv A 1012-1072 disorder
Seq 779-851 Monomer :
 Evidence NMR 2ct7 A Reference
       Region 2ct7 A 779-851 order
       Region 2ct7 A 779-791 high_rmsd
Seq 853-1072 Hetero dimer : P63048
 Evidence X-RAY 4ljo A Reference
       Region 4ljo A 853-856 disorder
       Region 4ljo A 857-1072 order
 Evidence X-RAY 4ljp A Reference
       Region 4ljp A 853-856 disorder
       Region 4ljp A 857-1071 order
       Region 4ljp A 1072-1072 disorder
Seq 853-1072 Monomer :
 Evidence X-RAY 4ljq B Reference
       Region 4ljq B 853-857 disorder
       Region 4ljq B 858-866 order
       Region 4ljq B 867-867 disorder
       Region 4ljq B 868-880 order
       Region 4ljq B 881-884 disorder
       Region 4ljq B 885-958 order
       Region 4ljq B 959-967 disorder
       Region 4ljq B 968-975 order
       Region 4ljq B 976-982 disorder
       Region 4ljq B 983-1070 order
       Region 4ljq B 1071-1072 disorder
 Evidence X-RAY 4ljq A Reference
       Region 4ljq A 853-857 disorder
       Region 4ljq A 858-866 order
       Region 4ljq A 867-867 disorder
       Region 4ljq A 868-879 order
       Region 4ljq A 880-884 disorder
       Region 4ljq A 885-958 order
       Region 4ljq A 959-966 disorder
       Region 4ljq A 967-973 order
       Region 4ljq A 974-982 disorder
       Region 4ljq A 983-1070 order
       Region 4ljq A 1071-1072 disorder
 Evidence X-RAY 4ljq C Reference
       Region 4ljq C 853-857 disorder
       Region 4ljq C 858-866 order
       Region 4ljq C 867-867 disorder
       Region 4ljq C 868-880 order
       Region 4ljq C 881-883 disorder
       Region 4ljq C 884-958 order
       Region 4ljq C 959-966 disorder
       Region 4ljq C 967-973 order
       Region 4ljq C 974-982 disorder
       Region 4ljq C 983-1070 order
       Region 4ljq C 1071-1072 disorder
 Evidence X-RAY 4ljq D Reference
       Region 4ljq D 853-858 disorder
       Region 4ljq D 859-866 order
       Region 4ljq D 867-867 disorder
       Region 4ljq D 868-879 order
       Region 4ljq D 880-883 disorder
       Region 4ljq D 884-958 order
       Region 4ljq D 959-966 disorder
       Region 4ljq D 967-973 order
       Region 4ljq D 974-982 disorder
       Region 4ljq D 983-1070 order
       Region 4ljq D 1071-1072 disorder
Seqphosphorylation
    383-383 Phosphoserine
    466-466 Phosphoserine
 
Prediction
NeProc
Disorder 1-7,187-237,247-481,681-685,1064-1072
Order 8-186,238-246,482-680,686-855,860-958,966-1063
ProS 214-237,247-256,303-326,351-377,410-436,1064-1068
AlphaFold
Disorder 1-2,177-215,259-302,316-316,328-352,358-358,366-366,373-373,376-376,378-411,424-426,436-475,624-624,626-633,753-760,788-795,803-805,807-807,892-892,962-966,976-976,978-982,1071-1072
Order 3-176,216-258,303-315,317-327,353-357,359-365,367-372,374-375,377-377,412-423,427-435,476-623,625-625,634-752,761-787,796-802,806-806,808-891,893-961,967-975,977-977,983-1070
Pfam Hmmer
PF00641 350-379 0.00073
SEG 34-47 ,148-164 ,201-216 ,281-294 ,331-347 ,454-472 ,957-968
Function
Function in SwissProt
E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173). LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846). Together with otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types (PubMed:23708998).