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IID00583
 UniprotQ9BQA1
ProteinMethylosome protein 50
GeneWDR77
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
342
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-342 Hetero octamer : IID00405Complex
 Evidence X-RAY 5emj B Reference
       Region 5emj B 2-25 disorder
       Region 5emj B 26-328 order
       Region 5emj B 329-342 disorder
 Evidence X-RAY 5emk B Reference
       Region 5emk B 2-15 disorder
       Region 5emk B 16-328 order
       Region 5emk B 329-342 disorder
 Evidence X-RAY 5eml B Reference
       Region 5eml B 2-18 disorder
       Region 5eml B 19-328 order
       Region 5eml B 329-342 disorder
 Evidence X-RAY 5emm B Reference
       Region 5emm B 2-15 disorder
       Region 5emm B 16-328 order
       Region 5emm B 329-342 disorder
Seq 2-342 Hetero dodecamer : IID00405Complex
 Evidence X-RAY 4gqb B Reference
       Region 4gqb B 2-20 disorder
       Region 4gqb B 21-207 order
       Region 4gqb B 208-211 disorder
       Region 4gqb B 212-244 order
       Region 4gqb B 245-246 disorder
       Region 4gqb B 247-329 order
       Region 4gqb B 330-342 disorder
Seq 2-342 Hetero dimer : IID00405Complex
 Evidence X-RAY 4x60 B Reference
       Region 4x60 B 2-18 disorder
       Region 4x60 B 19-328 order
       Region 4x60 B 329-342 disorder
 Evidence X-RAY 4x61 B Reference
       Region 4x61 B 2-23 disorder
       Region 4x61 B 24-207 order
       Region 4x61 B 208-210 disorder
       Region 4x61 B 211-328 order
       Region 4x61 B 329-342 disorder
 Evidence X-RAY 4x63 B Reference
       Region 4x63 B 2-19 disorder
       Region 4x63 B 20-328 order
       Region 4x63 B 329-342 disorder
 Evidence X-RAY 5c9z B Reference
       Region 5c9z B 2-15 disorder
       Region 5c9z B 16-328 order
       Region 5c9z B 329-342 disorder
Seq 2-342 Hetero trimer : IID00405Complex
 Evidence X-RAY 5fa5 B Reference
       Region 5fa5 B 2-20 disorder
       Region 5fa5 B 21-207 order
       Region 5fa5 B 208-211 disorder
       Region 5fa5 B 212-244 order
       Region 5fa5 B 245-247 disorder
       Region 5fa5 B 248-328 order
       Region 5fa5 B 329-342 disorder
Seqphosphorylation
    5-5 Phosphothreonine
 
Prediction
NeProc
Disorder 1-7,334-342
Order 8-333
ProS 4-7,334-342
AlphaFold
Disorder 1-16,208-211,245-245,330-342
Order 17-207,212-244,246-329
Pfam Hmmer
PF00400 157-196 1.1e-07
SEG 40-51
Function
Function in SwissProt
Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.